IL-1 Superfamily and Inflammasome

Dinarello, Charles A.

doi:10.1002/9783527692156.ch20

Cited by 3 publications

(17 citation statements)

References 239 publications

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“…This property of IL-1R2 results in signal inhibition. Decoy receptors are conserved evolutionary structures which restrict the chemokines, cytokines, and growth factors activities [ 45 – 48 , 68 , 128 , 129 , 134 ].…”

Section: Methods and Techniques For Determining Cytokinesmentioning

confidence: 99%

“…The IL-1 family members are naturally spread within the cell cytoplasm entirely as active and inactive precursors or active biomolecules. Each precursor is identified through its conserved consensus sequence of A-X-Asp, where the A depicts an aliphatic AA, the X is any AA, and Asp is the abbreviation for aspartic acid [ 134 , 139 ]. The caspase-1 cleavage site is situated some AAs before this motif.…”

Section: Methods and Techniques For Determining Cytokinesmentioning

confidence: 99%

“…The caspase-1 cleavage site is situated some AAs before this motif. For instance, the consensus motif A-X-Asp in the IL-1 ß precursor, Leu-Arg-Asp, is located nine AAs before the caspase-1 cleavage site [ 134 , 139 , 140 ].…”

Section: Methods and Techniques For Determining Cytokinesmentioning

confidence: 99%

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The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)

Behzadi

Sameer

Nissar

et al. 2022

Journal of Immunology Research

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Interleukins (ILs)—which are important members of cytokines—consist of a vast group of molecules, including a wide range of immune mediators that contribute to the immunological responses of many cells and tissues. ILs are immune-glycoproteins, which directly contribute to the growth, activation, adhesion, differentiation, migration, proliferation, and maturation of immune cells; and subsequently, they are involved in the pro and anti-inflammatory responses of the body, by their interaction with a wide range of receptors. Due to the importance of immune system in different organisms, the genes belonging to immune elements, such as ILs, have been studied vigorously. The results of recent investigations showed that the genes pertaining to the immune system undergo progressive evolution with a constant rate. The occurrence of any mutation or polymorphism in IL genes may result in substantial changes in their biology and function and may be associated with a wide range of diseases and disorders. Among these abnormalities, single nucleotide polymorphisms (SNPs) can represent as important disruptive factors. The present review aims at concisely summarizing the current knowledge available on the occurrence, properties, role, and biological consequences of SNPs within the IL-1 family members.

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Section: Methods and Techniques For Determining Cytokinesmentioning

confidence: 99%

Section: Methods and Techniques For Determining Cytokinesmentioning

confidence: 99%

See 1 more Smart Citation

The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)

Behzadi

Sameer

Nissar

et al. 2022

Journal of Immunology Research

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“…There are 11 members of IL-1 family of cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra IL-37, and IL-38) and 10 members of the IL-1 family of receptors (IL-1R1 to ILR10) [8,9]. More than any other cytokine family, the IL-1 family members are closely linked to damaging inflammation; however, the same members also work to increase nonspecific resistance to infection and the development of an immune response to a foreign antigen [10].…”

Section: Il-1 Family Of Cytokines and Innate Immune Systemmentioning

confidence: 99%

Cytokine Profiling Plays a Crucial Role in Activating Immune System to Clear Infectious Pathogens

Muñoz‐Carrillo¹,

Contreras-Cordero²,

Gutiérrez-Coronado³

et al. 2019

Immune Response Activation and Immunomodulation

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Pathogen infections are recognized by the immune system, which consists of two types of responses: an innate immune response that recognizes pathogenassociated molecular patterns (PAMPs) and an antigen-specific adaptive immune response. In both responses, there are several activated cells of the immune system, which play a key role in establishing the environment of cytokines, thus directing their differentiation either suppressing or promoting the immune response. This immune response is crucial against pathogen infections. In this chapter, we will describe the crucial role played by different families of cytokines during activation of the immune system to eliminate infectious pathogens.

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“…Cytokines can be classified into five groups [57]: (1) IL-1 superfamily, there are 10 members of the IL-1 family of receptors (IL-1R1-ILR10) [58] and 11 members of the IL-1 family of cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37 and IL-38) [59]. The interleukin-1 superfamily members are closely linked to damaging inflammation; however, the same members also function to increase nonspecific resistance to infection and the development of an immune response to foreign antigens [60]. (2) TNF superfamily is composed of 19 ligands and 29 receptors [61].…”

Section: Cytokinesmentioning

confidence: 99%

Immune System Disorders: Hypersensitivity and Autoimmunity

Muñoz‐Carrillo¹,

Castro-García²,

FranciscaChávez-Rubalcaba³

et al. 2018

Immunoregulatory Aspects of Immunotherapy

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The immune response is known as a physiological mechanism to protect the body, providing defense to different systems that compose it and allowing its proper functioning. The ability to keep the organism free from foreign agents depends on the mechanisms of natural resistance or innate immunity, as well as the resistance that can develop over time through adaptive immunity. However, when these defense mechanisms fail, it can trigger injuries and diseases in the tissues, such as hypersensitivity, which is characterized as an excessive and undesirable reaction, produced by the immune system; as well as autoimmunity, which refers to the failure of the mechanisms of immunological tolerance, causing the reaction of the immune system against the body itself.

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IL-1 Superfamily and Inflammasome

Cited by 3 publications

References 239 publications

The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)

The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)

Cytokine Profiling Plays a Crucial Role in Activating Immune System to Clear Infectious Pathogens

Immune System Disorders: Hypersensitivity and Autoimmunity

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