IL-10 and IL-17F Promoter Single Nucleotide Polymorphism and Asthma: A Case-Control Study in South India

Jahromi, Sareh Raeiszadeh; Mahesh, P A; Jayaraj, B.S.; Holla, Amrutha D.; Vishweswaraiah, Sangeetha; Ramachandra, Nallur B.

doi:10.1007/s00408-015-9753-3

Cited by 12 publications

(11 citation statements)

References 44 publications

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“…However, we found the frequency of the rs1889570 T/T genotype and T allele were markedly overrepresented in severe cases, including cases of EV71 encephalitis, when compared to mild cases and healthy controls, which suggested that the polymorphism in rs1889570 might be associated with the severity of EV71 infection in the Chinese Han population. This result is consistent with the reported results for asthma in a South Indian population [34] and tuberculosis in a Chinese population [35].…”

Section: Introductionsupporting

confidence: 93%

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Association of Interleukin-17F gene polymorphisms with susceptibility to severe enterovirus 71 infection in Chinese children

Guo

et al. 2018

Arch Virol

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Enterovirus 71 (EV71) is a single-strand RNA virus that causes hand, foot and mouth disease (HFMD) in infants and young children, leading to neurological complications with significant morbidity and mortality. Unfortunately, the pathogenesis of EV71 infection is not well understood. In this study, we investigated the IL-17F rs1889570 and rs4715290 gene polymorphisms in a Chinese Han population. Severe cases and cases with EV71 encephalitis had a significantly higher frequency of the rs1889570 T/T genotype and T allele. The serum IL-17F levels in rs1889570 T/T and C/T genotypes were also significantly elevated when compared to C/C genotypes. However, there was no significant difference observed in rs4715290 genotype distribution and allele frequency. These findings suggest that IL-17F rs1889570 gene polymorphisms are significantly associated with the susceptibility to severe EV71 infection in Chinese Han children.

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Section: Introductionsupporting

confidence: 93%

“…IL-17F rs1889570 and rs4715290 located in the promotor region. Previous studies have reported the IL-17F rs1889570 gene polymorphism as being involved in several diseases, such as asthma [33,34] and tuberculosis [35]. To date, no study has been performed on the rs4715290 gene polymorphism.…”

Section: Introductionmentioning

confidence: 99%

Association of Interleukin-17F gene polymorphisms with susceptibility to severe enterovirus 71 infection in Chinese children

Guo

et al. 2018

Arch Virol

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“…Of these studies, 33 met the inclusion criteria (Fig. ), with 29 being candidate gene studies (Table S3) and four being GWAS .…”

Section: Methodsmentioning

confidence: 99%

“…Only four SNPs within three genes ( CRHR1: rs242941, rs1876828 ; GLCCI1: rs37973 and FCER2: rs28364072) were positively replicated at least once (Table ). Response to medication was assessed using different outcomes: lung function measurements such as changes in FEV1 over time , annual decline in FEV1 , bronchial hyperresponsiveness [BHR] to methacholine , asthma symptoms based on questionnaires and exacerbations despite treatment .…”

Section: Methodsmentioning

confidence: 99%

Pharmacogenomics of inhaled corticosteroids and leukotriene modifiers: a systematic review

Farzan

Vijverberg

Arets

et al. 2016

Clin Experimental Allergy

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“…Researchers from India showed a positive correlation of the AA variant IL-17F, rs1887570, with the number of sensitizing allergens in patients with asthma [ 81 ]. Expression of IL-17C was increased in lesional AD skin [ 82 ].…”

Section: Interleukin Il-17mentioning

confidence: 99%

New Cytokines in the Pathogenesis of Atopic Dermatitis—New Therapeutic Targets

Klonowska¹,

Gleń

Nowicki

et al. 2018

IJMS

150

108

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Atopic dermatitis (AD) is a recurrent, chronic, and inflammatory skin disease, which processes with severe itchiness. It often coexists with different atopic diseases. The number of people suffering from AD is relatively high. Epidemiological research demonstrates that 15–30% of children and 2–10% adults suffer from AD. The disease has significant negative social and economic impacts, substantially decreasing the quality of life of the patients and their families. Thanks to enormous progress in science and technology, it becomes possible to recognise complex genetic, immunological, and environmental factors and epidermal barrier defects that play a role in the pathogenesis of AD. We hope that the new insight on cytokines in AD will lead to new, individualised therapy and will open different therapeutic possibilities. In this article, we will focus on the cytokines, interleukin (IL)-17, IL-19, IL-33, and TSLP (thymic stromal lymphopoietin), which play a significant role in AD pathogenesis and may become the targets for future biologic therapies in AD. It is believed that the new era of biological drugs in AD will give a chance for patients to receive more successful treatment.

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IL-10 and IL-17F Promoter Single Nucleotide Polymorphism and Asthma: A Case-Control Study in South India

Abstract: We observed an association between IL-10 rs1800871 and rs1800896 SNPs and mild asthma, as well as IL-17F rs1887570 AA variant and number of allergens sensitized.

Cited by 12 publications

References 44 publications

Association of Interleukin-17F gene polymorphisms with susceptibility to severe enterovirus 71 infection in Chinese children

Association of Interleukin-17F gene polymorphisms with susceptibility to severe enterovirus 71 infection in Chinese children

Pharmacogenomics of inhaled corticosteroids and leukotriene modifiers: a systematic review

New Cytokines in the Pathogenesis of Atopic Dermatitis—New Therapeutic Targets

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