IL-10 and its related cytokines for treatment of inflammatory bowel disease

Li, Mingcai; He, Shaoheng

doi:10.3748/wjg.v10.i5.620

Cited by 225 publications

(149 citation statements)

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“…IL-10 is mainly produced by regulatory T-cells and helps to down-regulate the production of pro-inflammatory cytokines (Moore et al, 2001). The importance of IL-10 in controlling the intestinal inflammation was shown by IL-10 deficient mice which eventually developed enterocolitis (Kuhn et al, 1993) or by beneficial therapeutic effects of IL-10 in human IBD and in experimental colitis (Li and He, 2004;Lindsay et al, 2004). However, there were no significant differences in IL-10 mRNA abundance in duodenum and colon between FRD, IBD and control groups, in accordance with earlier studies (German et al, 2000;Ridyard et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Cytokine mRNA abundance in intestinal biopsies from dogs with chronic diarrhea

Sauter¹,

Allenspach²,

Blum³

2007

Vet. Med. - Czech

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ABSTRACT:The differentiation between inflammatory bowel disease (IBD) and food responsive diarrhea (FRD) is difficult and no objective markers are available. We postulated that patterns of selected key cytokines would help to objectively differentiate between the two subcategories of chronic enteropathies in dogs. We studied mRNA patterns of selected cytokines in dogs with chronic enteropathies. Ten dogs with FRD (= group FRDbef ) and seven dogs with IBD (= group IBDbef ) were presented for endoscopy at the Small Animal Clinic, University of Bern. A control endoscopy was performed in both groups after treatment with an elimination diet for four weeks (FRDaft) or with an elimination diet combined with prednisolone for 10 weeks (IBDaft). Intestinal control samples of gastrointestinally healthy dogs from an independent study were additionally available. Dogs were clinically examined and scored using the canine IBD activity index (CIBDAI). mRNA abundance of interleukin (IL)-5, -10, -12p40, and -13, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β1, and interferon (IFN)-γ were analyzed in intestinal samples by reverse transcription and real time polymerase chain reaction. Median CIBDAI decreased in FRDaft (P < 0.01) and IBDaft (P = 0.07) during treatment. In duodenum, IL-12p40 mRNA levels tended to be lower in FRDbef than in IBDbef (P = 0.07). The abundance of TNF-α mRNA was higher in IBDbef than in control dogs (P < 0.05). IL-5 mRNA levels decreased in FRD dogs during treatment (P = 0.06), and IL-10 mRNA levels decreased in IBD dogs (P < 0.05). In colon, IL-5 and IL-12p40 mRNA levels were lower in FRDbef than in IBDbef (P < 0.05) and control dogs (P < 0.01). IL-13 mRNA abundance was lower in FRDbef than in control dogs (P < 0.05) and IFN-γ mRNA abundance was lower in FRD and IBD dogs than in control dogs (P < 0.01). Feeding the elimination diet additionally reduced IFN-γ mRNA levels (P < 0.01), but increased TNF-α mRNA levels (P < 0.05) in FRD dogs. In conclusion, mRNA levels of the selected cytokines before treatment did not show clear differences between FRD and IBD dogs.

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Section: Discussionmentioning

confidence: 99%

Cytokine mRNA abundance in intestinal biopsies from dogs with chronic diarrhea

Sauter¹,

Allenspach²,

Blum³

2007

Vet. Med. - Czech

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“…Therefore, the predominant populations of LPMCs expressing MGL1 were considered to be macrophages, although they expressed CD11c. Because many reports previously suggested that IL-10 plays a key role in the modulation of DSS-induced experimental colitis in mice as well as Crohn's disease and ulcerative colitis in humans, 28 the expression of IL-10 mRNA by MGL1-positive macrophage-like cells was investigated. CD11b ϩ and F4/80-high cells, which consist of the MGL1-positive cells, were shown to contain significantly higher levels of IL-10 mRNA than F4/80-intermediate MGL1-negative cells ( Figure 2C).…”

Section: Properties Of Lamina Propria Mgl1-positive Cellsmentioning

confidence: 99%

A C-Type Lectin MGL1/CD301a Plays an Anti-Inflammatory Role in Murine Experimental Colitis

Saba

Denda-Nagai

Irimura

2009

The American Journal of Pathology

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“…Although their etiology is not yet fully known, the initiation and aggravation of the inflammatory process seem to be due to a dysregulated immune responses with a parallel increase in the expressions of pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8 (Hyun and Mayer 2006;Shih and Targan 2008). At the same time, deficiency of IL-10, an anti-inflammatory cytokine, seems to contribute to persistent intestinal inflammation (Li and He 2004;Shih and Targan 2008). Clinical reports have well document an increased risk of intestinal cancer in UC and CD patients (Askling et al 2001;Eaden et al 2001;Jess et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients

Szkaradkiewicz

Marciniak

Chudzicka-Strugała

et al. 2009

Arch. Immunol. Ther. Exp.

114

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Introduction: The aim of the study was to describe the levels of circulating monocyte/macrophage pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8) and an anti-inflammatory cytokine (IL-10) in inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients and healthy controls. Materials and Methods:The study was conducted on 15 healthy individuals, 20 patients with ulcerative colitis (UC), 12 with Crohn's disease (CD), and 15 with CRC (Dukes' stage B). Blood serum cytokine levels were measured by ELISA. Results: The patients with UC had significantly higher levels of the pro-inflammatory cytokines and of circulating IL-10 than the healthy controls. The patients with CD and CRC had the same specific pattern of serum cytokines of significantly elevated levels of the pro-inflammatory cytokines, but the IL-10 levels were within the range found in the healthy individuals. Conclusions: Thus our results demonstrate that both IBD and CRC are linked with an intensified production of a wide array of monocyte/macrophage pro-inflammatory cytokines which is not accompanied by elevated levels of circulating IL-10, except for its insufficiently inhibitory elevation in UC patients.

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IL-10 and its related cytokines for treatment of inflammatory bowel disease

Cited by 225 publications

References 50 publications

Cytokine mRNA abundance in intestinal biopsies from dogs with chronic diarrhea

Cytokine mRNA abundance in intestinal biopsies from dogs with chronic diarrhea

A C-Type Lectin MGL1/CD301a Plays an Anti-Inflammatory Role in Murine Experimental Colitis

Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients

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