IL-10 and TNF-β gene polymorphisms have no major influence on lactate levels after cardiac surgery☆

Interleukin-10 (IL-10) is a cytokine with anti-inflammatory and B-cell-stimulating activity. IL-10 is expressed in human atherosclerotic plaques and studies have shown the involvement of IL-10 in the atherosclerotic process. The IL-10-1082G/A polymorphism is one of the most commonly studied polymorphisms in this gene because of its association with coronary heart disease (CHD) risks, but previous results have been conflicting. We performed a meta-analysis using six eligible case-control studies (including 14 data sets) with a total of 5006 patients and 3968 controls to summarize the existing data on the association between the IL-10-1082G/A polymorphism and CHD risk. Compared with the common IL-10-1082G/A GG genotype, the carriers of variant genotypes (IL-10-1082GA/AA) had a 1.12-fold elevated risk of CHD (95% CI = 1.01-1.23, P = 0.03) under the dominant genetic model, as estimated using a random effect model. The effect of the IL-10-1082G/A polymorphism was further evaluated using stratification analysis. In the three disease of artery studies, with the variant genotypes had a not obvious increased risk of disease of artery (OR = 1.19, 95% CI = 0.98-1.44, P = 0.08) as estimated using a fixed effect model. Similar results were found in the nine myocardial infarction studies (OR = 1.13, 95% CI = 1.00-1.27, P = 0.05). It was also demonstrated that the increased risk of CHD associated with IL-10-1082G/A variant genotypes was more pronounced in Caucasians (OR = 1.12, 95% CI = 1.01-1.23, P = 0.03). Our meta-analysis suggests that the IL-10-1082G/A polymorphism genotypes (GA+AA) might be associated with an increased risk of CHD, especially in Caucasians.

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“…There were three data sets concerning disease of artery (Koch et al. , 2001; Riha et al. , 2006; Bown et al.…”

Section: Resultsmentioning

confidence: 99%

Association between the Interleukin 10−1082G>A polymorphism and coronary heart disease risk in a Caucasian population: a meta‐analysis

Wang

Zheng

Liu

et al. 2011

Int J Immunogenetics

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The Association of Promoter Gene Polymorphisms of the Tumor Necrosis Factor-α and Interleukin-10 with Severity of Lactic Acidosis During Liver Transplantation Surgery

Farahat

Salah

Mokhtar

et al. 2012

Transplantation Proceedings

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Identification of Inflammatory Mediators and Their Modulation by Strategies for the Management of the Systemic Inflammatory Response During Cardiac Surgery

Hall

2013

Journal of Cardiothoracic and Vascular Anesthesia

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IL-10 and TNF-β gene polymorphisms have no major influence on lactate levels after cardiac surgery☆

Abstract: IL-10 (-1082G/A) and TNF-beta (+252G/A) gene polymorphisms have a little, yet measurable influence on the time course of changes in lactate levels after cardiac surgery.

Cited by 4 publications

References 15 publications

Association between the Interleukin 10−1082G>A polymorphism and coronary heart disease risk in a Caucasian population: a meta‐analysis

Association between the Interleukin 10−1082G>A polymorphism and coronary heart disease risk in a Caucasian population: a meta‐analysis

The Association of Promoter Gene Polymorphisms of the Tumor Necrosis Factor-α and Interleukin-10 with Severity of Lactic Acidosis During Liver Transplantation Surgery

Identification of Inflammatory Mediators and Their Modulation by Strategies for the Management of the Systemic Inflammatory Response During Cardiac Surgery

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