IL-10 c.-592C&gt;A (rs1800872) polymorphism is associated with cervical cancer

Pereira, Ana Paula Lombardi; Trugilo, Kleber Paiva; Okuyama, Nádia Calvo Martins; Sena, Michelle Mota; Couto-Filho, José d’Oliveira; Watanabe, Maria Angélica Ehara; Oliveira, Karen Brajão de

doi:10.1007/s00432-020-03256-0

Cited by 18 publications

(10 citation statements)

References 42 publications

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“…Several candidate gene studies have reported an association to exist between IL-10 promoter polymorphisms and cervical cancer susceptibility. Thus, women harboring the higher IL-10 production variant have an increased risk of cervical cancer and premalignant lesions, which has been verified across several populations [61][62][63][64][65][66]. These observations have been also confirmed in meta-analyses of not only cervical cancer [67] but also in head and neck cancer [68], indicating that IL-10 plays a crucial role in the host immune response to HPV.…”

Section: Genetic Variants and Hpv-induced Cervical Cancermentioning

confidence: 62%

Genetic Predisposition to Persistent Human Papillomavirus-Infection and Virus-Induced Cancers

Espinoza

Pham

et al. 2021

Microorganisms

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Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens worldwide and among the more than 200 identified HPV types, approximately 15 high risk (HR-HPV) types are oncogenic, being strongly associated with the development of cervical cancer, anogenital cancers and an increasing fraction of head and neck squamous cell carcinomas (HNSCC). HPV-associated cervix cancer accounts for 83% of HPV-attributable cancers, and more than two-thirds of those cases occur in developing countries. Despite the high frequency of HPV infections, in most cases, the virus is cleared by the host immune response and only a small proportion of infected individuals develop persistent infections that can result in malignant transformation, indicating that other elements, including biological, genetic and environmental factors may influence the individual susceptibility to HPV-associated cancers. Previous studies have quantified that heritability, in the form of genetic variants, common in the general population, is implicated in nearly 30% of cervical cancers and a large number of studies conducted across various populations have identified genetic variants that appear to be associated with genes that predispose or protect the host to HPV infections thereby affecting individual susceptibility to HPV-associated cancers. In this article, we provide an overview of gene association studies on HPV-associated cancers with emphasis on genome-wide association study (GWAS) that have identified novel genetic factors linked to HPV infection or HPV-associated cancers.

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Section: Genetic Variants and Hpv-induced Cervical Cancermentioning

confidence: 62%

Genetic Predisposition to Persistent Human Papillomavirus-Infection and Virus-Induced Cancers

Espinoza

Pham

et al. 2021

Microorganisms

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“…Furthermore, Torres-Poveda et al and Pereira et al found a correlation between the −592C/A polymorphism and cervical cancer in the Mexican and Brazilian populations for all three models, respectively [ 17 , 21 ]. Zoodsma et al, Du et al, and Datta et al reported that the risk of cervical cancer was correlated with the −592C/A SNP in the IL-10 gene for the dominant and additive models in Netherlander, Chinese, and Bangladeshi populations, respectively [ 6 , 7 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis

et al. 2022

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A literature review showed some discrepancies regarding the association of -592C/A with the risk of cervical cancer. To allow more precise analysis of the data by increasing the number of cases studied and more acceptable generalization by considering results from different sources, the present meta-analysis was performed on available published studies that explored the relationship between SNP-592C/A of the IL-10 gene and the risk of cervical cancer. Eleven available studies, including 4187 cases and 3311 controls, were included in this study investigating the relationship between the -592C/A polymorphism of IL-10 and cervical cancer risk. Fixed-effects or random-effects models were performed with pooled odds ratios (ORs). Heterogeneity and bias tests were performed by the inconsistency test and funnel plot, respectively. The overall analysis showed an increased susceptibility to cervical cancer with the -592C/A polymorphism of the IL-10 gene for the recessive model (OR = 1.30, 95% CI = 1.14–1.49), dominant model (OR = 1.36, 95% CI = 1.09–1.70), and additive model (OR = 1.25, 95% CI = 1.09–1.44). Regarding ethnicity, a significant association of the -592C/A polymorphism of the IL-10 gene was linked to an elevated risk of cervical cancer for all genetic models (recessive, dominant, and additive) in the Asian populations and for the recessive and additive models in Caucasians with P < 0.05 . The -592C/A polymorphism of the IL-10 gene may be considered a risk factor for cervical cancer.

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“…Nowadays, it is acknowledged that the production of some cytokines is under genetic control and that polymorphisms in several cytokine genes, mainly SNPs or microsatellites, located in regulatory regions, may affect gene transcription and cause inter-individual variations. Some of these polymorphisms have been identi ed and in uence the level of cytokine production, which may confer exibility in the immune response [26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

IL17A G197A and IL17F T7488C genotypes of IL-17 gene as biomarkers in keratoconus

Gomes

Ayo

Lopes

et al. 2021

Preprint

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Investigate possible correlations between genetic polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) with the development of keratoconus (KC) in patients from a population of the northwestern part of the State of São Paulo. Were enrolled 35 patients and 61 controls. Genotyping of IL17A G197A and IL17F T7488C polymorphisms was carried out using the PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Length Polymorphism) technique. The evaluation of IL17F T7488C SNP found that the TT genotype is associated as a risk factor for the development of KC (P = 0.04; OR = 2.97; CI = 1.09–8.33). As for the evaluation of IL17A G197A SNP, the allele and genotype frequencies between patients and controls were compared and no statistically significant differences were found. The TT genotype of IL17F T7488C SNP apparently contributes to the development of KC and the IL17A G197A SNP seemingly has no influence on the progression of the disease in the population of this study.

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IL-10 c.-592C>A (rs1800872) polymorphism is associated with cervical cancer

Cited by 18 publications

References 42 publications

Genetic Predisposition to Persistent Human Papillomavirus-Infection and Virus-Induced Cancers

Genetic Predisposition to Persistent Human Papillomavirus-Infection and Virus-Induced Cancers

Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis

IL17A G197A and IL17F T7488C genotypes of IL-17 gene as biomarkers in keratoconus

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