IL-10 Contributes to the Inhibition of Contact Hypersensitivity in Mice Treated with Photodynamic Therapy

Simkin, G; Tao, Jing-Song; Levy, Julia G.; Hunt, David W. C.

doi:10.4049/jimmunol.164.5.2457

Cited by 45 publications

(34 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5). It seems that this suppression involves systemic IL10 release in cases where the PDT illumination penetrates the skin (red light) 131 , but is independent of IL10 when the PDT is confined to the skin layers (blue light)132. In contrast to UVB irradiation that suppresses both CHS and delayed type hypersensitivity (DTH) responses, PDT does not suppress DTH133.…”

Section: Immunosuppressive Effects Of Pdtmentioning

confidence: 99%

Photodynamic therapy and anti-tumour immunity

2006

View full text Add to dashboard Cite

Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.The principle of photodynamic therapy (PDT) was first proposed over 100 years ago 1 . A recent review in Nature Reviews Cancer by Rakesh Jain and colleagues described some of the historical milestones in the development of PDT as a cancer treatment2. Many of the photosensitizers (PSs) that have been studied since PDT was first proposed are based on a porphyrin-like nucleus 3 . PSs function as catalysts when they absorb visible light and then convert molecular oxygen to a range of highly reactive oxygen species (ROS). The ROS that are produced during PDT have been shown to destroy tumours by multifactorial mechanisms4 , 5 (FIG. 1). PDT has a direct affect on cancer cells, producing cell death by necrosis and/or apoptosis 6 . PDT also has an affect on the tumour vasculature, whereby illumination and ROS production causes the shutdown of vessels and subsequently deprives the tumour of oxygen and nutrients 7,8 . Finally, PDT also has a significant effect on the immune system 9-11 , which can be either immunostimulatory or immunosuppressive.Most of the commonly used cancer therapies are immunosuppressive. Chemotherapy and ionizing radiation delivered at doses sufficient to destroy tumours are known to be toxic to the bone marrow, which is the source of all cells of the immune system, and neutropaenia and other forms of myelosuppression are often the dose-limiting toxicity of these therapies. However, it should be noted that low doses of either ionizing radiation12 , 13 or chemotherapy14 can have immunostimulatory effects, including the induction of heat-shock © 2006 Nature Publishing Group Correspondence to M.R.H. Hamblin@helix.mgh.harvard.edu. Competing interests statementThe authors declare no competing financial interests. DATABASES NIH Public Access Author ManuscriptNat Rev Cancer. Author manuscript; available in PMC 2010 September 6. Published in final edited form as:Nat Rev Cancer. 2006 July ; 6(7): 535-545. doi:10.1038/nrc1894. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript proteins 15 . Less well known is the fact that major surgery can also have an immunosuppressive effect that leads to a significant diminution of lymphocyte and natural killer (NK) cell function 16 . The ideal cancer therapy would not only destroy the primary tumour, but at the same time trigger the immune system to recognize, track down and destroy any remaining tumour cells, be they at or near the site of the primary tumour or distant microm...

show abstract

Section: Immunosuppressive Effects Of Pdtmentioning

confidence: 99%

Photodynamic therapy and anti-tumour immunity

2006

View full text Add to dashboard Cite

show abstract

“…In a CHS model in mice verteporfin (BPD-MA) administration followed by the whole body irradiation led to induction of IL-10 expression in skin [125]. Moreover, treatment of wild type animals with neutralizing anti-IL-10 antibodies or administration of recombinant IL-12, a cytokine that promotes development of cellular immune response, reversed immunosuppressive effects of PDT [128]. However, not all studies confirm the importance of IL-10 in PDT-mediated suppression of the immune responses as no difference in CHS development in IL-10 knockout versus wild type mice has been observed [129].…”

Section: Photoimmunotherapy and Pdt-mediated Immunomodulationmentioning

confidence: 99%

Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity

et al. 2010

View full text Add to dashboard Cite

Photodynamic therapy (PDT) utilizes the destructive power of reactive oxygen species generated via visible light irradiation of a photosensitive dye accumulated in the cancerous tissue/cells, to bring about their obliteration. PDT activates multiple signalling pathways in cancer cells, which could give rise to all three cell death modalities (at least in vitro). Simultaneously, PDT is capable of eliciting various effects in the tumour microenvironment thereby affecting the tumour-associated/-infiltrating immune cells and by extension, leading to infiltration of various immune cells (e.g. neutrophils) into the treated site. PDT is also associated to the activation of different immune phenomena, e.g. acute-phase response, complement cascade and production of cytokines/chemokines. It has also come to light that, PDT is capable of activating 'anti-tumour adaptive immunity' in both pre-clinical as well as clinical settings. Although the ability of PDT to induce 'anti-cancer vaccine effect' is still debatable, yet it has been shown to be capable of inducing exposure/release of certain damage-associated molecular patterns (DAMPs) like HSP70. Therefore, it seems that PDT is unique among other approved therapeutic procedures in generating a microenvironment suitable for development of systemic anti-tumour immunity. Apart from this, recent times have seen the emergence of certain promising modalities based on PDT like-photoimmunotherapy and PDT-based cancer vaccines. This review mainly discusses the effects exerted by PDT on cancer cells, immune cells as well as tumour microenvironment in terms of anti-tumour immunity. The ability of PDT to expose/release DAMPs and the future perspectives of this paradigm have also been discussed.

show abstract

“…Immunosuppressive roles for IL-10 have been extensively documented, including those in airway inflammation (22) and contact sensitivity (23). The biological significance of the reduced IL-10 production by btk Ϫ/Ϫ DCs was assessed.…”

Section: Btk Regulates Il-10 Production͞secretion In Dcsmentioning

confidence: 99%