IL-10 correlates with the expression of carboxypeptidase B2 and lymphovascular invasion in inflammatory breast cancer: The potential role of tumor infiltrated macrophages

Mohamed, Hossam Taha; El-Husseiny, Noura; El-Ghonaimy, Eslam A.; Ibrahim, Sherif; Bazzi, Zainab A.; Boffa, Michael B.; El-Shinawi, Mohamed; Mohamed, Mona Mostafa

doi:10.1016/j.currproblcancer.2018.01.009

Cited by 22 publications

(17 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, details about signaling and intercellular interaction require further investigation. Mohamed reported that IL10 secreted by tumor-infiltrating monocytes/macrophages (CD14+/CD16+) separated from inflammatory breast cancer patients positively correlated with the expression level of CPB2 , which was crucial to lymphovascular invasion in inflammatory breast cancer 26. However, further studies are required to clarify the role of IL10 in seminoma.…”

Section: Discussionmentioning

confidence: 99%

<p>Identification of key genes and pathways in seminoma by bioinformatics analysis</p>

Chen

Lin

et al. 2019

OTT

View full text Add to dashboard Cite

Background: Seminoma accounts for the most part of cases of testicular germ cell tumor, which is the most common malignancy among males between ages 15 and 44 years. Understanding the molecular mechanism of tumorigenesis is important for better clinical diagnosis and treatment. Purpose: We performed bioinformatics analysis to better understand seminoma at the genetic level and to explore potential candidate genes or molecules for diagnosis, treatment, and prognosis. Methods: A gene expression profile (GSE8607), containing 40 seminoma samples and three healthy testes samples, was analyzed to identify differentially expressed genes (DEGs) associated with the occurrence of seminoma. Functional annotation was then performed using gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. Cytoscape with Search Tool for the Retrieval of Interacting Genes was used to construct a protein–protein interaction (PPI) network of the DEGs and select hub genes. Moreover, validation of expression level and Kaplan–Meier analysis for overall survival were conducted to those hub genes. Results: A total of 1,636 DEGs were identified between seminoma and healthy samples, including 701 up-regulated in seminoma that were enriched in the regulation of immune responses, defense responses, receptor activity, and signal transducer activity; 935 were down-regulated in seminoma and were associated with reproductive processes, kinase activity, and carbohydrate derivative binding. Five hub genes were selected from the PPI network according to the degree of connectivity: IL6, VEGFA, IL10, CCR5 , and CXCR4 . Among them, high expression levels of CCR5 and CXCR4 were associated with poor prognosis for seminoma patients. Four modules selected from the PPI network revealed that seminoma was connected with the Janus kinase-signal transducers and activators of transcription signaling pathway, chemokine signaling pathway, endocytosis, and cytokine–cytokine receptor interaction. Conclusion: These identified DEGs and hub genes facilitate our knowledge of the underlying molecular mechanism of seminoma and have the potential to be used as diagnostic biomarkers or therapeutic targets for seminoma.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Identification of key genes and pathways in seminoma by bioinformatics analysis</p>

Chen

Lin

et al. 2019

OTT

View full text Add to dashboard Cite

show abstract

“…However, some studies found higher IL10 levels in metastatic lymph nodes and IL10 polymorphisms associated with increased expression in patients with lymph node-positive breast cancer (107,108). Interestingly, high IL10 levels were also found in inflammatory breast cancer, a particularly aggressive and highly metastatic form of breast cancer, in which this cytokine correlates with the presence of lymphovascular invasion (109). This parameter has been recently associated with an increased risk of BCRL in patients with left side localization.…”

Section: Biological Characteristics Of the Primary Tumorsmentioning

confidence: 99%

Integrating Biological Advances Into the Clinical Management of Breast Cancer Related Lymphedema

et al. 2020

View full text Add to dashboard Cite

Breast cancer-related lymphedema (BCRL) occurs in a significant number of breast cancer survivors as a consequence of the axillary lymphatics' impairment after therapy (mainly axillary surgery and irradiation). Despite the recent achievements in the clinical management of these patients, BCRL is often diagnosed at its occurrence. In most cases, it remains a progressive and irreversible condition, with dramatic consequences in terms of quality of life and on sanitary costs. There are still no validated pre-surgical strategies to identify individuals that harbor an increased risk of BCRL. However, clinical, therapeutic, and tumor-specific traits are recurrent in these patients. Over the past few years, many studies have unraveled the complexity of the molecular and transcriptional events leading to the lymphatic system ontogenesis. Additionally, molecular insights are coming from the study of the germline alterations involved at variable levels in BCRL models. Regrettably, there is a substantial lack of predictive biomarkers for BCRL, given that our knowledge of its molecular milieu remains extremely puzzled. The purposes of this review were (i) to outline the biology underpinning the ontogenesis of the lymphatic system; (ii) to assess the current state of knowledge of the molecular alterations that can be involved in BCRL pathogenesis and progression; (iii) to discuss the present and shortterm future perspectives in biomarker-based patients' risk stratification; and (iv) to provide practical information that can be employed to improve the quality of life of these patients.

show abstract

“…In three relevant articles, we could not extract the data we wanted. [42][43][44] Second, the sample sizes in some subgroups were small. Third, there were inconsistencies in the types of controls across studies.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis

Zhu

Liu

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

Objective To evaluate the correlation between interleukin 10 (IL-10) −1082A/G polymorphism (rs1800896) and breast cancers by performing a meta-analysis. Methods The Embase and Medline databases were searched through 1 September 2018 to identify qualified articles. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were applied to evaluate associations. Results In total, 14 case-control studies, including 5320 cases and 5727 controls, were analyzed. We detected significant associations between the IL10 −1082 G/G genotype and risk of breast cancer (AA + AG vs. GG: OR = 0.88, 95% CI = 0.80–0.97). Subgroup analyses confirmed a significant association in Caucasian populations (OR = 0.89, 95% CI = 0.80–0.99), in population-based case-control studies (OR = 0.87, 95% CI = 0.78–0.96), and in studies with ≥500 subjects (OR = 0.88, 95% CI = 0.79–0.99) under the recessive model (AA + AG vs. GG). No associations were found in Asian populations. Conclusions The IL10 −1082A/G polymorphism is associated with an increased risk of breast cancer. The association between IL10 −1082 G/G genotype and increased risk of breast cancer is more significant in Caucasians, in population-based studies, and in larger studies.

show abstract

IL-10 correlates with the expression of carboxypeptidase B2 and lymphovascular invasion in inflammatory breast cancer: The potential role of tumor infiltrated macrophages

Cited by 22 publications

References 58 publications

<p>Identification of key genes and pathways in seminoma by bioinformatics analysis</p>

<p>Identification of key genes and pathways in seminoma by bioinformatics analysis</p>

Integrating Biological Advances Into the Clinical Management of Breast Cancer Related Lymphedema

Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis

Contact Info

Product

Resources

About