IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway

Sun, Yang; Song, Xue; Geng, Zhijun; Xu, Yibo; Xiao, Linyu; Chen, Yue; Li, Bohan; Shi, Jinran; Wang, Lian; Wang, Yueyue; Zhang, Xiaofeng; Zuo, Lugen; Li, Jing; Lü, Hezuo; Hu, Jianguo

doi:10.1016/j.intimp.2023.111367

Cited by 4 publications

(1 citation statement)

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“…The initial inflammatory response to SCI, marked by the invasion of neutrophils and the onset of oxidative stress, further triggers the activation of the JAK/STAT signaling pathway [46,47].…”

Section: Jak/stat Before and After Activationmentioning

confidence: 99%

NF-κB and JAK/STAT Signaling Pathways as Crucial Regulators of Neuroinflammation and Astrocyte Modulation in Spinal Cord Injury

Ageeva,

Rizvanov,

Mukhamedshina

2024

Cells

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Spinal cord injury (SCI) leads to significant functional impairments below the level of the injury, and astrocytes play a crucial role in the pathophysiology of SCI. Astrocytes undergo changes and form a glial scar after SCI, which has traditionally been viewed as a barrier to axonal regeneration and functional recovery. Astrocytes activate intracellular signaling pathways, including nuclear factor κB (NF-κB) and Janus kinase-signal transducers and activators of transcription (JAK/STAT), in response to external stimuli. NF-κB and STAT3 are transcription factors that play a pivotal role in initiating gene expression related to astrogliosis. The JAK/STAT signaling pathway is essential for managing secondary damage and facilitating recovery processes post-SCI: inflammation, glial scar formation, and astrocyte survival. NF-κB activation in astrocytes leads to the production of pro-inflammatory factors by astrocytes. NF-κB and STAT3 signaling pathways are interconnected: NF-κB activation in astrocytes leads to the release of interleukin-6 (IL-6), which interacts with the IL-6 receptor and initiates STAT3 activation. By modulating astrocyte responses, these pathways offer promising avenues for enhancing recovery outcomes, illustrating the crucial need for further investigation into their mechanisms and therapeutic applications in SCI treatment.

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Section: Jak/stat Before and After Activationmentioning

confidence: 99%