2002
DOI: 10.1046/j.1365-3083.2002.01101.x
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IL‐12: The Role of p40 Versus p75

Abstract: Interleukin (IL)-12p75 is a heterodimeric cytokine composed of the product of two different genes that specify p35 and p40 subunits. The prevailing view is that IL-12 acts as a proinflammatory cytokine that bridges the innate and adaptive immune responses and skews T-cell reactivity toward a T H 1 cytokine pattern. Though the terms IL-12 and IL-12p40 are often used interchangeably, and measurements of the p40 chain are often interpreted as measurements of the intact p75 heterodimer, such interchangeable usage … Show more

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Cited by 92 publications
(68 citation statements)
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References 108 publications
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“…This seems to be consistent with the literature indicating that DCs do not constantly express the p35 subunit and as a result their secretion of the IL-12(p70) heterodimer compared to p40 may be modest (Abdi 2002, Stephens et al 2003.…”
Section: Discussionsupporting
confidence: 93%
“…This seems to be consistent with the literature indicating that DCs do not constantly express the p35 subunit and as a result their secretion of the IL-12(p70) heterodimer compared to p40 may be modest (Abdi 2002, Stephens et al 2003.…”
Section: Discussionsupporting
confidence: 93%
“…A major source of IL-12 is the antigen-presenting cells, such as dendritic cells and macrophages; these cells often produce IL-12 in response to bacterial products (8,10,13). IL-12 has a central function in initiating and regulating cellular immune responses by stimulating gamma interferon (IFN-␥) production in both natural killer (NK) cells and helper T cells via binding its receptor comprised of two subunits, IL-12 receptor ␤1 (IL-12R␤1) and IL-12R␤2 (1,10). Thus, we hypothesized that IL-12 can enhance vaccine efficacy, since Y. pestis is an intracellular pathogen.…”
mentioning
confidence: 99%
“…This appears in according with the major role for IL-12 cytokine that bridges the innate and acquired immune response, leading T-cell response toward to Th1 cytokine profile 1,23 .…”
Section: Discussionmentioning
confidence: 97%