IL-17 and IL-22 genetic polymorphisms in HBV vaccine non- and low-responders among healthcare workers

Abstract

Background Healthcare workers constitute a population at high risk for HBV infection. Efficient vaccination options are available; however, the individual response to HBV vaccination may vary widely between subjects, potentially due to cytokine profiles and genetic variations. In the present study, we investigated the relationship between IL-17 and IL-22 gene polymorphisms versus non-and lowresponsiveness to HBV vaccination in healthcare workers.Methods We selected the following IL-17 and IL-22 polymorphisms: rs4711998 (A/G) from IL-17 and rs2227501 (A/T), rs2227503 (A/G), rs1026786 (A/G) from IL-22 sequences genes. These were determined by polymerase chain reaction restriction fragment length polymorphisms.Results The IL-17 rs4711998 GG genotype had a significantly lower frequency in non-responders compared to low-responders (p=0.025). However, we did not identify a relationship between IL-22 rs1026780, rs2227501 and rs2227503 genotypes and the anti-HBs response following HBV vaccination.Conclusion These data suggest that genetic variation in rs4711998 polymorphisms in the IL-17 cytokine may influence vaccine-induced immune responses to HBV vaccine in healthcare workers.

Levels of Interleukin-17 and Vitamin D and Their Correlation in Viral Hepatitis Patients

“…Present results indicated that patient group had a lower trimmed mean than the control group, this may be attributed to their responsiveness to treatment or efficiency in the immune system because treatment responders tend to have lower IL 17 expression as concluded by an Iranian study done in 2016, [11] That result suggests a shift in immunity towards the TH1 side rather than TH 17. It was also suggested that antiviral treatment lowers the levels of IL-17 in patients' serum.…”

Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran

“…Cytokines represent a substantial role in initiating and maintaining a suitable immune and inflammatory response of HBV infection through direct or indirect inhibition of viral replication (15,(41)(42)(43)(44)(45)(46). Therefore, several recent studies have paid attention to the effect of gene polymorphisms of cytokines on infectious disease outcome, response to vaccination and treatment.…”

Vaccinomics and adversomics: key elements for a personalized vaccinology

“…Moreover, genetic association analysis revealed that SNPs in CXCR5 (rs497916, rs3922, rs676925) and in CXCL13 (rs355687) are associated with HBV-vaccine response [ 31 ], as well as the SNPs rs17470171 and rs17385627 in the IRG1 (immune-responsive gene 1) gene are associated with the immune response to HBV vaccination [ 32 ]. Finally, Borzooy et al [ 33 ] in 2016 demonstrated that the IL-17 rs4711998 GG genotype had a significantly lower frequency in non-responders to HBV vaccination. Therefore, from what has been said, it is noted that multiple alleles and polymorphisms are involved in the response to anti-HBV vaccination.…”