IL-17 in cutaneous lupus erythematosus

Tănăsescu, C; Bălănescu, Eugenia; Bălănescu, Paul; Olteanu, Rodica; Badea, Camelia; Grancea, Camelia; Vagu, Codruţa; Bleoţu, Coralia; Ardeleanu, Carmen; Georgescu, Anca Meda

doi:10.1016/j.ejim.2010.03.004

Cited by 92 publications

(69 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The exact source of IL-21 in lupus patients is not known. Notably, TFH and Th17 cells are elevated in the peripheral blood of SLE patients, and positively correlate with disease activity [31,32] [31,33,34]. Thus, current data suggest that TFH and Th17 cells may be the major producers of IL-21 in SLE patients, although this remains to be formally shown.…”

Section: Production Of Il-21mentioning

confidence: 70%

“…these patients [31,32]. IL-17 is also detectable in the affected skin and kidneys of cutaneous lupus patients [31,33,34]. Further, evidence from the BXD2 and MRL-Fas lpr animal models of lupus also demonstrate that Th17 cells and IL-17 may be key mediators of disease pathology in SLE [69][70][71].…”

Section: Enhancement Of T Cell Differentiation Proliferation and Effmentioning

confidence: 83%

See 1 more Smart Citation

Role of IL-21 in Systemic Lupus Erythematosus

Jung¹,

Guay²

2011

J Clin Cell Immunol

View full text Add to dashboard Cite

Systemic lupus erythematosus is a chronic autoimmune disease that affects multiple organ systems and tissues. Activation and differentiation of autoreactive T and B cells, and the formation of pathogenic autoantibodies are central to disease pathogenesis. IL-21 is the most recently identified member of the family of cytokines whose receptors share the common γ c . IL-21 is a pleotropic cytokine that regulates the activation, differentiation and expansion of B and T cells. Here, we review the role of IL-21 in T and B cell biology, and provide insight into the potential role of IL-21 in the development of SLE.

show abstract

Section: Production Of Il-21mentioning

confidence: 70%

Section: Enhancement Of T Cell Differentiation Proliferation and Effmentioning

confidence: 83%

Role of IL-21 in Systemic Lupus Erythematosus

Jung¹,

Guay²

2011

J Clin Cell Immunol

View full text Add to dashboard Cite

show abstract

“…These results support the relationship between APF and the spectrum of neutrophilic dermatoses and highlight that this entity may be regarded as a less aggressive form as compared to PG. In our study, IL-17 proved to be expressed in APF as well as in PG and Sweet's syndrome, suggesting a potential role for this cytokine in the pathophysiology ofthe whole spectrum of neutrophilic dermatoses, as recently recognized in psoriasis (19) and LE (20). IL-17 is a proinflammatory cytokine produced primarily by a new T helper cell subset termed "Th 17" (21) that exerts its effects through the recruitment ofmonocytes and neutrophils by increasing the local production of chemokines, most notably IL-8 (22).…”

Section: Fig 5 Immunohistochemical Studies Of Matrix Metalloproteinmentioning

confidence: 90%

Inflammatory Cells, Cytokines and Matrix Metalloproteinases in Amicrobial Pustulosis of the Folds and other Neutrophilic Dermatoses

Marzano

Cugno

Trevisan

et al. 2011

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Amicrobial pustulosis of the folds (APF) is a rare cutaneous disease characterized by relapsing sterile pustules frequently associated with autoimmune disorders. Although APF pathophysiology is still undefined, scattered reports suggest involvement of neutrophils. The aim of the present study is to evaluate the role of the skin inflammatory infiltrate, selected multifunctional cytokines and effectors of tissue damage in APF and other neutrophilic dermatoses. We studied, by immunohistochemical methods, inflammatory cell markers (CD3, CD163, myeloperoxidase), cytokines (TNF-α, IL-8, IL-17), metalloproteinases (MMP-2, MMP-9) and vascular-endothelial-growth-factor (VEGF) in lesional skin from six patients with APF, 11 with pyoderma gangrenosum (PG), 7 with Sweet's syndrome, and in 20 normal skin samples. Immunoreactivities of CD3, CD163, myeloperoxidase, TNF-α, IL-8, IL-17, MMP-2, MMP-9 and VEGF were significantly higher in APF, PG and Sweet's syndrome than in controls (p=0.0001). IL-8 was more expressed in PG than in APF (P=0.002) and Sweet's syndrome (p=0.001). In APF, MMP-9 reactivity was higher than in Sweet's syndrome, (p=0.035), but less intense than in PG (p=0.020). Our study supports the role of proinflammatory cytokines/chemokines and MMPs as important effectors for the tissue damage in APF similarly to classic neutrophilic dermatoses.

show abstract

“…However, the disease activity negatively correlated with the urinary IL-17A mRNA. Freshly isolated peripheral blood T cells of patients with SLE also contain increased level of IL-17A and a higher percentage of IL-17 + T cells compared to healthy controls [78][79][80]. Although transcripts encoding IL-17A, IL-23 and IL-6 were upregulated in the PBMC of SLE patients, some but not all studies have found correlation between serum IL-17A level with disease activity scores and renal involvement [78,81].…”

Section: Th17/il-17-axis In Human Glomerulonephritismentioning

confidence: 94%