IL-17 in human asthma

Silverpil, Elin; Lindén, Anders

doi:10.1586/ers.12.12

Cited by 35 publications

(25 citation statements)

References 149 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, several drugs that target IL-17 signaling are being tested in clinical trials. Several tries aim to find whether there are any specific features of this heterogeneous disease that potentially could be relieved by the use of IL-17-targeting drugs (Silverpil and Lindén, 2012). Conclusion: our study reveal that there was a significant increase in IL-17 and IgE serum levels in asthmatic group than in control children with a significant positive correlation between them.…”

Section: Discussion:-mentioning

confidence: 59%

Study of Serum Interleukin 17 Level in Children With Bronchial Asthma.

Bazzari¹,

Aly²,

Hassib³

2016

IJAR

View full text Add to dashboard Cite

Section: Discussion:-mentioning

confidence: 59%

Study of Serum Interleukin 17 Level in Children With Bronchial Asthma.

Bazzari¹,

Aly²,

Hassib³

2016

IJAR

View full text Add to dashboard Cite

“…Treg and Th-17) has also been proposed in asthma (Cosmi et al, 2011;Maddur et al, 2012;Ray et al, 2010;Silverpil & Lind é n, 2012;Strickland & Holt, 2011). Production of the Treg phenotype is associated with the expression of the transcription factor Foxp3 (Marson et al, 2007;Romagnani, 2006) and whose activity is also dependent upon NF-AT (Wu et al, 2006).…”

Section: Cd4mentioning

confidence: 99%

Role of Transcription Factors in the Pathogenesis of Asthma and COPD

Caramori¹,

Casolari²,

Adcock

2013

Cell Communication & Adhesion

View full text Add to dashboard Cite

Infl ammation is a central feature of asthma and chronic obstructive pulmonary disease (COPD). Despite recent advances in the knowledge of the pathogenesis of asthma and COPD, much more research on the molecular mechanisms of asthma and COPD are needed to aid the logical development of new therapies for these common and important diseases, particularly in COPD where no effective treatments currently exist. In the future the role of the activation/repression of different transcription factors and the genetic regulation of their expression in asthma and COPD may be an increasingly important aspect of research, as this may be one of the critical mechanisms regulating the expression of different clinical phenotypes and their responsiveness to therapy, particularly to anti-infl ammatory drugs.

show abstract

“…Previous clinical studies have demonstrated that the proportion of Th17 cells in the BALF, sputum and lung tissue, as well as the serum levels of IL-17, in asthma patients were significantly increased compared with those in normal control patients, and were positively associated with the severity of asthma symptoms (8,19–21). In addition, certain studies using animal asthma models have also shown that Th17 cells and their cytokines, including IL-17A and IL-17F, are involved in antigen-induced neutrophil recruitment, as well as in the enhancement of Th2 cell-mediated eosinophil recruitment into the airways (22,23).…”

Section: Discussionmentioning

confidence: 95%

Chinese herbal medicine formula Gu-Ben-Fang-Xiao-Tang attenuates airway inflammation by modulating Th17/Treg balance in an ovalbumin-induced murine asthma model

Ruan

Tao

Wang

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Gu-Ben-Fang-Xiao-Tang (GBFXT) is a traditional Chinese medicine formula consisting of 11 medicinal plants, which has been used in the treatment of asthma. The present study aimed to determine the protective effects and the underlying mechanisms of GBFXT on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. A total of 50 mice were randomly assigned to the following five experimental groups: Normal, model, montelukast (2.6 mg/kg), 12 g/kg GBFXT and 36 g/kg GBFXT groups. Airway responsiveness was measured using the forced oscillation technique, while differential cell count in the bronchoalveolar lavage fluid (BALF) was measured by Wright-Giemsa staining. Histological assessment was performed by hematoxylin and eosin staining, while BALF levels of Th17/Treg cytokines were measured by enzyme-linked immunosorbent assay, and the proportions of Th17 and Treg cells were evaluated by flow cytometry. The results showed that GBFXT suppressed airway hyperresponsiveness during methacholine-induced constriction, reduced the percentage of leukocytes and eosinophils, and resulted in decreased absolute neutrophil infiltration in lung tissue. In addition, GBFXT treatment significantly decreased the IL-17A cytokine level and increased the IL-10 cytokine level in the BALF. Furthermore, GBFXT significantly suppressed Th17 cells and increased Treg cells in asthmatic mice. In conclusion, the current results demonstrated that GBFXT may effectively inhibit the progression of airway inflammation in allergic asthma, partially by modulating the Th17/Treg cell balance.

show abstract

IL-17 in human asthma

Cited by 35 publications

References 149 publications

Study of Serum Interleukin 17 Level in Children With Bronchial Asthma.

Study of Serum Interleukin 17 Level in Children With Bronchial Asthma.

Role of Transcription Factors in the Pathogenesis of Asthma and COPD

Chinese herbal medicine formula Gu-Ben-Fang-Xiao-Tang attenuates airway inflammation by modulating Th17/Treg balance in an ovalbumin-induced murine asthma model

Contact Info

Product

Resources

About