IL-17 in Sera from Patients with Aggressive Periodontitis

Schenkein, Harvey A.; Koertge, Thomas E.; Brooks, Carol N.; Sabatini, Robert; Purkall, D.E.; Tew, John G.

doi:10.1177/0022034510369297

Cited by 79 publications

(85 citation statements)

References 32 publications

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“…This was in accordance with Vernal et 52 who used these parameters to assess the periodontal status.…”

Section: Without Patient Education (B)supporting

confidence: 88%

Untitled

2015

IJPSR

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Background:Periodontal disease is one of the two main and most prevalent oral diseases all over the world. Treatment strategies are diverse. To date, scaling and root planing (SRP) is still the gold standard non-surgical therapy for periodontitis. Systemically administered antibiotics can be used as an adjunct to SRP to improve the treatment outcome of periodontitis. Purpose: To compare clinical outcome of systemically administered doxycycline versus combination of amoxicillin and metronidazole as an adjunct to SRP in the management of chronic periodontitis patients. Methods: This study was conducted on forty-two moderate to severe generalized chronic periodontitis patients who received non-surgical periodontal therapy. Following SRP, patients were randomly allocated to one of the following groups; group (I) received Doxycycline (loading dose 200 mg and maintenance dose 100 mg/day) for fifteen days, group (II) received a combination therapy of amoxicillin and metronidazole (750 mg/day) for eight days and group III (control group) which was treated by SRP without administration of systemic antibiotic therapy. The periodontal parameters; Plaque index (PI), Gingival index (GI), Probing depth (PD) and Clinical attachment level (CAL) were examined for the assessment of the clinical outcome. Results: This study revealed that combination of amoxicillin and metronidazole resulted in significant reduction in PD and significant gain in CAL. Conclusion: The combination of Amoxicillin and Metronidazole at a dose of 750 mg/day for eight days had a significant effect on enhancing the clinical outcome of chronic periodontitis patients.

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“…This was in accordance with Vernal et 52 who used these parameters to assess the periodontal status.…”

Section: Without Patient Education (B)supporting

confidence: 88%

Untitled

2015

IJPSR

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“…Sample size calculation was performed prior to the beginning of the study for all objectives using independent t-test under PS software 9 based on comparing two means from the previous study by Schenkein et al 10 All clinical measurements were performed by a single calibrated examiner. The intra-examiner reliability and reproducibility on measurements of PPD and CAL had been assessed prior to the beginning of the study.…”

Section: Thismentioning

confidence: 99%

Serum interleukin-17 (IL-17) in chronic periodontitis patients

et al. 2017

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Introduction: Explorations into the periodontal medicine relationship have discovered interleukin-17 (IL-17) cytokine as one of the pro-inflammatory mediators that play a crucial role in the initiation and progression of the chronic periodontal disease. This case and control study aimed to compare the serum IL-17 concentration between chronic periodontitis and healthy subjects and to assess the relationship between the IL-17 serum and the clinical periodontal parameters in chronic periodontitis patients. Methods: This study was a case-control study. The subjects were selected using purposive sampling method. The periodontal screening assessment in the Family Treatment Center and Postgraduate Dental Clinic, Universiti Sains Malaysia Hospital. A total of 55 samples who fit with the inclusion and exclusion study criteria of full-mouth clinical periodontal records together with blood serums were obtained from 28 chronic periodontitis patients and from 27 healthy subjects. The concentration of IL-17 cytokine in serum was measured using ELISA test. Results: Subjects with periodontal disease presented significantly worse clinical parameters (p<0.001) compared to control. The level of serum IL-17 concentration was significantly higher (p=0.026) in chronic periodontitis subjects 3.6 (1.03) pg/mL compared to the control 3.1 (0.70) pg/mL. Conclusions: There was no correlation between the level of IL-17 concentration in the serum and clinical periodontal parameters.

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“…Furthermore, elevated levels of IL-17A have been detected in serum [6][7][8] saliva [8,9] and gingival crevicular fluid (GCF) [8,10,11] of periodontitis patients. Serum and GCF levels of IL-17A have also been demonstrated to correlate with clinical attachment loss in patients with chronic periodontitis [7,8,11] and aggressive periodontitis [7].…”

Section: Introductionmentioning

confidence: 99%

The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio

et al. 2016

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. (2016) The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A: IL-17E ratio. Clinical Oral Investigations, 20(9), pp. 2529-2537. (doi:10.1007/s00784-016-1749 This is the author's final accepted version.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/116253/ The serum IL-17A:IL-17E ratio has previously been demonstrated to be a clinical marker of periodontitis. The aim of this study was to determine the effects of non-surgical periodontal treatment on the serum IL-17A:IL-17E ratio. MATERIALS AND METHODS:Forty chronic periodontitis patients completed this study and received periodontal treatment comprising scaling and root planing plus ultrasonic debridement. Clinical data were recorded at baseline, six weeks (R1) after treatment completion (full-mouth or quadrant-scaling and root planing) and 25 weeks after baseline (R2). Serum samples were taken at each time point and cytokines concentrations determined by ELISA. RESULTS:Following treatment, statistically significant reductions were noted in clinical parameters. However, IL-17A and IL-17E concentrations were significantly greater than baseline values before-and after-adjusting for smoking. The IL-17A:IL-17E ratio was lower at R1 and R2. Serum IL-6 and TNF levels were significantly lower at R1 only. Also exclusively at R1, serum IL-17A and IL-17E correlated positively with clinical parameters, while the IL-17A:IL-

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IL-17 in Sera from Patients with Aggressive Periodontitis

Cited by 79 publications

References 32 publications

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Serum interleukin-17 (IL-17) in chronic periodontitis patients

The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio

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