IL-17 induces radiation resistance of B lymphoma cells by suppressing p53 expression and thereby inhibiting irradiation-triggered apoptosis

Liu, Qingshan; Xu, Xin; Zhong, Weide; Du, Quan; Yu, Bizhen; Xiong, Huabao

doi:10.1038/cmi.2014.122

Cited by 25 publications

(33 citation statements)

References 29 publications

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“…IL-17 could suppress p53 expression and thereby repress irradiation-triggered apoptosis of lymphoma cells. 90 Therefore, we speculate that IL-17 is a key prognostic factor for lymphoma. Further studies are still needed to reveal the risk conferred by IL-17 overexpression with respect to the onset of lymphoma in patients with pSS.…”

Section: Discussionmentioning

confidence: 88%

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Expression of interleukin‐17 in primary Sjögren's syndrome and the correlation with disease severity: A systematic review and meta‐analysis

et al. 2018

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The aberrant expression of interleukin-17 (IL-17) has been reported in primary Sjögren's syndrome (pSS). Abnormalities in IL-17 can promote the production of pro-inflammatory cytokines and aggravate autoimmune disorders. The aim of this study was to investigate alterations of IL-17 in patients with pSS and explore the correlation between IL-17 and disease severity. Eight databases were searched for original studies reporting the expression of IL-17 in patients with pSS and controls. Eligible reports were included in the pooled analysis, and subgroup evaluations were performed according to different types of controls and IL-17 measurement methods. Newcastle-Ottawa Scale criteria were used to assess the risk of bias of the included studies. In total, 45 articles are included in the meta-analysis. The expression of IL-17 is significantly increased in patients with pSS compared to controls. Furthermore, patients with pSS without immunosuppressive treatment show markedly higher IL-17 levels. In addition, patients with pSS with positive rheumatoid factors tend to express a higher level of IL-17 than patients with negative rheumatoid factors. Negative correlations between IL-17 levels and ocular parameters are also found in patients with pSS. The results are similar after adjustment by "trim and fill" methods. In conclusion, the expression of IL-17 is obviously increased in patients with pSS, especially among those without immunosuppressive treatment. In addition, IL-17 level correlates with the disease severity of pSS. These findings demonstrate the significance of IL-17 overexpression in patients with pSS and may provide insights for the development of therapeutic interventions targeting IL-17 for pSS.

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Section: Discussionmentioning

confidence: 88%

“…Moreover, IL‐17 may be prognostic factor for B lymphoma by inducing radiation resistance. IL‐17 could suppress p53 expression and thereby repress irradiation‐triggered apoptosis of lymphoma cells . Therefore, we speculate that IL‐17 is a key prognostic factor for lymphoma.…”

Section: Discussionmentioning

confidence: 88%

Expression of interleukin‐17 in primary Sjögren's syndrome and the correlation with disease severity: A systematic review and meta‐analysis

et al. 2018

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“…Our results indicated that irradiated k1106 cells induce the production of IL-17 from Treg cells. 12 Previous studies demonstrated that anti-IL-6 does not reverse resistance to radiation and chemotherapy in lymphoma cells, suggesting that resistance is not directly mediated by IL-6 and could potentially involve other cytokines or other signaling pathways. Radiotherapy kills DLBCL cells mainly through apoptosis.…”

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confidence: 99%

“…In conclusion, we demonstrated that IL-17 induces radiotherapy resistance in B-cell lymphoma. 12 IL-6 is produced by a variety of cells, including monocytes, fibroblasts, epithelial cells and hematological tumor cells. Our data were consistent with previous data demonstrating that naive k1106 cells produce detectable IL-6, which is upregulated after irradiation.…”

mentioning

confidence: 99%

“…Our previous study provided an explanation for this finding. 12 The serine/threonine protein kinase tumor progression locus 2 (TPL2), which belongs to the mitogen-activated protein kinase (MAPK) family, is widely distributed in tumor cells. The 'doublesided effect' of TPL2 depends on the different upstream and downstream signals in the TME or on the tumor type.…”

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confidence: 99%

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Rituximab or irradiation promotes IL-17 secretion and thereby induces resistance to rituximab or irradiation

Zhong

Liu

2017

Cell Mol Immunol

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Limitations for Extraterrestrial Colonisation and Civilisation Built and the Potential for Human Enhancements

Braddock¹

2020

Human Enhancements for Space Missions

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IL-17 induces radiation resistance of B lymphoma cells by suppressing p53 expression and thereby inhibiting irradiation-triggered apoptosis

Cited by 25 publications

References 29 publications

Expression of interleukin‐17 in primary Sjögren's syndrome and the correlation with disease severity: A systematic review and meta‐analysis

Expression of interleukin‐17 in primary Sjögren's syndrome and the correlation with disease severity: A systematic review and meta‐analysis

Rituximab or irradiation promotes IL-17 secretion and thereby induces resistance to rituximab or irradiation

Limitations for Extraterrestrial Colonisation and Civilisation Built and the Potential for Human Enhancements

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