IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

Xu, Bing; Li, Y T; Dong, Shuxiao; Qi, J; Feng, Hui; Li, Zi; Yang, Dongmei

doi:10.4238/gmr.15027756

Cited by 8 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 35 It is also in agreement with the results that the IL-17A gene A allele is involved in susceptibility of CRC and suggested that IL-17A polymorphism may serve as a biomarker of CRC treatment outcome and progression in Tunisian patients. 15 , 36 A previous study also reported a positive correlation between AA genotype of IL-17A G197A polymorphism and increased risk of developing gastric cancer in a Chinese population, 37 although Wu et al did not find similar association with gastric cancer in the overall analysis in Chinese patients. 13 Han et al described IL-17A G-197A being closely associated with susceptibility to the development of osteoarthritis in the Korean population.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

IL-17 and colorectal cancer risk in the Middle East: gene polymorphisms and expression

Obeed

Vaali-Mohammed

Al‐Khayal

et al. 2018

CMAR

View full text Add to dashboard Cite

BackgroundIL-17 expressed by Th17 cells play a crucial role in tissue inflammation by induction of proinflammatory and neutrophil mobilizing cytokines, and IL-17 polymorphisms are associated with colorectal cancer (CRC).ObjectiveWe investigated the expression of IL-17 and the association of IL-17 gene polymorphisms with CRC susceptibility in a Middle East population.Materials and methodsThe study included 117 diagnosed CRC patients and 100 age- and gender-matched healthy controls. IL-17A rs2275913 (G197A) and IL-17F rs763780 (T7488C) single nucleotide polymorphisms, mRNA, and protein levels of IL-17A were assessed.ResultsWe observed significant association between rs2275913 in IL-17A and susceptibility to CRC (p = 0.016228). The AG and AA genotypes conferred 2-fold and 2.8-fold, respectively, higher risk of developing CRC compared with individuals having GG genotype. Stratification of the data based on gender and age revealed very strong association of CRC with IL17A rs2275913 only in males and “AG” genotype in patients ≤57 years of age at the time of disease diagnosis. The rs763780 in IL-17F was not linked with CRCs in our cohort. Furthermore, IL-17A mRNA expression in CRCs was significantly elevated compared to adjacent normal tissues, particularly in early stages of disease (p = 0.0005). Strong immunoreactivity to IL-17A protein was observed in 70% of early stage relative to 30% of late-stage tumors.ConclusionThe IL-17A G197A variant may be utilized as a genetic screening marker in assessing CRC risk, and its expression can be used as a biomarker for early detection of CRC in the Saudi population.

show abstract

Section: Discussionmentioning

confidence: 92%

“… 10 Several studies have indicated that IL-17 is associated with CRC and gastric cancer. 11 , 12 Increased expression of IL-17A has been reported in CRC patients. 13 In contrast, excessive production of IL-17F inhibits colon tumorigenesis in human and animal CRC models.…”

Section: Introductionmentioning

confidence: 99%

IL-17 and colorectal cancer risk in the Middle East: gene polymorphisms and expression

Obeed

Vaali-Mohammed

Al‐Khayal

et al. 2018

CMAR

View full text Add to dashboard Cite

show abstract

“…IL-17A gene, which is located on chromosome 6p12.23 in human genome, encodes the IL-17A cytokine. Recently, several polymorphisms in the IL-17A gene were identified, among them, rs1974226 and rs3748067 polymorphisms in the 3’ untranslated region (3’ UTR) of the IL-17A gene, and rs2275913 polymorphism in the promoter of the IL-17A gene, which were reported to be functional in influencing individual’s susceptibility to a huge numbers of human diseases, such as gastric cancer [ 32 – 35 ], pulmonary tuberculosis [ 36 ], asthma [ 37 – 39 ], osteoarthritis [ 40 ], rheumatoid arthritis [ 41 ], and CAD [ 42 – 44 ]. However, to date, no study has been reported on the association between polymorphisms in the IL-17A gene and IS risk.…”

Section: Introductionmentioning

confidence: 99%

The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke

Huang

Wang

et al. 2017

Oncotarget

View full text Add to dashboard Cite

The aim of our study was to investigate the association of interleukin-17A (IL-17A) polymorphisms with IL-17A serum levels and risk of ischemic stroke (IS) in a Chinese population. 392 IS patients and 443 controls were included in this study. The polymorphisms of IL-17A gene were determined by Snapshot SNP genotyping assay and DNA sequencing. Serum IL-17A levels were measured by enzyme-linked immunosorbent assay (ELISA). We found that the G allele, GA and GG genotypes, and GA/GG vs. AA model of rs2275913 polymorphism were associated with increased risk of IS even after adjusted by clinical characters such as age, gender and diabetes (G vs. A: OR=1.27, 95% CI, 1.05∼1.54, P=0.014; GA vs. AA: OR=1.72, 95% CI, 1.05∼2.81, P=0.032; GG vs. AA: OR=1.99, 95% CI, 1.08∼3.67, P=0.028; GA/GG vs. AA: OR=1.78, 95% CI, 1.11∼2.86, P=0.017). Serum IL-17A levels were increased in IS patients compared with controls (P<0.01). Individuals carrying rs2275913 GA or GG genotype present higher serum IL-17A levels compared with the rs2275913AA genotype in the IS group (P<0.01). In conclusion, this is the first study reporting the rs2275913 polymorphism as a risk factor for IS, which may be partly explained by influencing the levels of IL-17A cytokine.

show abstract

“…The effects of sex and age on pain‐related phenotypes were evaluated using nonparametric analyses in a previous study . According to most previous reports of the rs2275913 SNP, a recessive model led to significant differences . Therefore, we also adopted a recessive model (AA vs AG + GG) to divide the patients.…”

Section: Methodsmentioning

confidence: 99%

“…The rs2275913 SNP is located in the promoter region of the IL‐17A gene, and the A allele of rs2275913 is associated with higher promoter activity of the IL‐17A gene . The AA genotype of the rs2275913 SNP of the IL‐17A gene is reportedly associated with a higher risk of asthma, bronchiolitis, ulcerative colitis, digestive cancer, gastric cancer, and cervical cancer . Other studies reported that the rs2275913 SNP had no association with pediatric systemic lupus erythematosus disease activity or cervical cancer and had opposite effects on rheumatoid arthritis, post‐bronchiolitis asthma at 11‐13 years of age and colorectal cancer .…”

Section: Introductionmentioning

confidence: 99%

Association between rs2275913 single‐nucleotide polymorphism of the interleukin‐17A gene and perioperative analgesic use in cosmetic orthognathic surgery

Ohka

Nishizawa

Hasegawa

et al. 2018

Neuropsychopharm Rep

View full text Add to dashboard Cite

Aim: Interleukin-17A (IL-17A) plays an essential role in tissue inflammation by inducing proinflammatory cytokine and chemokine production and is related to innate immune reactions. IL-17A also contributes to neuroinflammation, neuropathic pain, and mechanical hypersensitivity after peripheral nerve injury in rodents. To clarify the contribution of IL-17A to pain-related phenotypes in humans, we investigated the association between pain-related phenotypes and the rs2275913 single-nucleotide polymorphism (SNP) of the IL-17A gene, which has been reported to be associated with rheumatoid arthritis, ulcerative colitis, and some cancers. Methods:The present study used a correlational design to examine the impact of the rs2275913 SNP on postoperative pain-related phenotypes in a group of patients who underwent cosmetic orthognathic surgery.Results: Carriers of the AA genotype had higher opioid requirements during and after surgery than carriers of the AG and GG genotypes (P = .009). Linear regression analysis indicated that opioid requirements linearly increased as the copy number of the A allele of the SNP increased (P = .008). Conclusions:Opioid requirements during and after surgery are enhanced in carriers of the AA genotype of the rs2275913 SNP of the IL-17A gene, possibly through an enhancement of IL-17A function that induces inflammation that is related to the inflammatory pain stimulus.analgesics, human, IL17A protein, opioid, orthognathic surgery, pain, polymorphism, postoperative, single-nucleotide Ohka and Nishizawa contributed equally to this work.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

show abstract

IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

Cited by 8 publications

References 27 publications

IL-17 and colorectal cancer risk in the Middle East: gene polymorphisms and expression

IL-17 and colorectal cancer risk in the Middle East: gene polymorphisms and expression

The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke

Association between rs2275913 single‐nucleotide polymorphism of the interleukin‐17A gene and perioperative analgesic use in cosmetic orthognathic surgery

Contact Info

Product

Resources

About