2008
DOI: 10.1093/intimm/dxn069
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IL-17A is produced by Th17,    T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance

Abstract: T(h)17 cells represent a new pro-inflammatory T(h) cell lineage distinct from T(h)1 and T(h)2 cells. T(h)17 cells have been shown to be involved in extracellular bacterial infection but their role in intracellular infection remains unclear. We found antigen-specific IL-17A production during a systemic infection of mice with the facultative intracellular bacterium Salmonella enterica serovar Enteritidis (S. Enteritidis) and examined the function and cellular source of IL-17A during the adaptive immune response … Show more

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Cited by 117 publications
(105 citation statements)
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“…involved in the pathology of DTH (Schulz et al, 2008). In fact, Th17 cells and IL-17 production are known to be increased in DTH mice, and blocking IL-17 can amelioet al, 2002;Irmler et al, 2007).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…involved in the pathology of DTH (Schulz et al, 2008). In fact, Th17 cells and IL-17 production are known to be increased in DTH mice, and blocking IL-17 can amelioet al, 2002;Irmler et al, 2007).…”
Section: Resultsmentioning
confidence: 99%
“…cells. Second, the recall response of T cells is evoked by -ic CD4 + T cells, play an important role in the development of DTH response, which reaches a peak 24 to 48 et al, 2002;Schulz et al, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…3,35 The imbalanced production of cytokines by T cells is associated with the activation and exhaustive status of memory T cells in HIV-infected patients. 36 Here, we assessed the production of IL-17 and IFN-c by cd T cells in HIV-infected (Figure 6a).…”
Section: Chronic Immune Activation Depletes Memory Vd 2 CD T Cells Inmentioning
confidence: 99%
“…We therefore determined the effect of exposing SMG neurons to the inflammatory mediators released from activated splenocytes. In vitro restimulation of isolated spleen cells by ConA induces polyclonal T cell differentiation, leading to the release of cytokine mediators of the adaptive immune response (Palacios, 1982;Schulz et al, 2008). We incubated distal SMG neurites in supernatant obtained from activated T lymphocytes for 5 d and measured neurite extension in compartmented cultures.…”
Section: Supernatant From Activated T Lymphocytes Evokes Neurite Outgmentioning
confidence: 99%