IL-17D affects the chemokines and chemokine receptors of intestinal epithelial cells under hyperoxia

Li, Tianming; Liu, Yanping; Yu, Xuefei; Wang, Pingchuan; Sun, Siyu; Liu, Dongyan

doi:10.1016/j.intimp.2022.109386

Cited by 2 publications

(1 citation statement)

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“…IL-17C is produced by epithelial cells, which stimulates the production of chemokines and antimicrobial peptides (Miura et al 2023 ). IL-17D is produced by various cells, including dendritic cells, tumour cells, and others, which activate natural killer cells and T cells (Li et al 2022 ). Th2 cells produce IL-17E, commonly known as IL-25, essential to allergic inflammation (Yuan et al 2023 ).…”

Section: Brief Overview Of Interleukin 17 (Il-17)mentioning

confidence: 99%

Risk of candidiasis associated with interleukin-17 inhibitors: Implications and management

Bilal,

Khan,

Khan

et al. 2023

Mycology

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The application of interleukin-17 (IL-17) inhibitors, including secukinumab, ixekizumab, brodalumab, and bimekizumab, are associated with elevated risk of candidiasis. These medications interfere with the IL-17 pathway, which is essential for maintaining mucosal barriers and coordinating the immune response against Candida species. The observational data and clinical trials demonstrate the increased incidence of candidiasis in individuals treated with IL-17 inhibitors. Brodalumab and bimekizumab pose a greater risk than secukinumab in eliciting candidiasis, whereas the data regarding ixekizumab are equivocal. Higher doses and prolonged treatment duration of IL-17 inhibitors increase the risk of candidiasis by compromising the immune response against Candida species. Prior to prescribing IL-17 inhibitors, healthcare professionals should comprehensively evaluate patients’ medical histories and assess their risk factors. Patients should be educated on the signs and symptoms of candidiasis to facilitate early detection and intervention. Future research should focus on identifying the risk factors associated with candidiasis in patients receiving IL-17 inhibitors. Prospective studies and long-term surveillance are required to explore the impact of specific inhibitors on the incidence and severity of candidiasis and to evaluate the effectiveness of combination therapies, such as concurrent use of IL-17 inhibitors and prophylactic antifungal agents.

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Section: Brief Overview Of Interleukin 17 (Il-17)mentioning

confidence: 99%