IL-18 Contributes to Renal Damage after Ischemia-Reperfusion

Abstract

IL-18 is a proinflammatory cytokine produced by macrophages and other cell types present in the kidney during ischemia-reperfusion injury (IRI), but its role in this injury is unknown.

Urinary Interleukin (Il)-18 as an Early Predictive Biomarker of Subclinical Proximal Tubular Dysfunction in HIV-Infected Patients Exposed to Tenofovir

“…Furthermore, Edelstein et al [1] pointed out that IL-18 can also be a very useful predictive marker of renal insufficiency. In this study there was a statistically significant difference in IL-18 levels between each time points in the TDF regiment group, thus confirming earlier results from classic laboratory tests [15]. In this study Estimated glomerular filtration rate (eGFR) increased only slightly at 12 weeks of exposure particularly in the TDF regimen group pointing a delay in the detection of proximal tubular dysfunction compared to IL-18 that shows a marked increased at 4 weeks.…”

“…The present study appears to be the first investigation in this area. Interleukin-18 has been described especially as a promising marker already in use to assess renal function after transplantations in metabolic diseases and heart diseases [10,[13][14][15]. The results of the present study suggest that an increase in the urinary concentration of IL-18 followed the expression of classic laboratory features of renal insufficiency.…”

Inflammasome Activation by Cystine Crystals

“…Interestingly, the inflammasome-regulated cytokines IL-1b and IL-18 are implicated in several animal models or human forms of CKD. [18][19][20] In this study, we used LPS to prime the inflammasome because the nature of the immunostimulatory priming signals in cystinosis are unknown. Indeed, on the basis of the evidence that pattern recognition receptors can also be activated by host-derived nonmicrobial stimuli (i.e., sterile inflammation), 21 we hypothesize that, in vivo, the priming of the inflammasome can be provided by endogenous molecules that are released during cellular injury (especially in kidneys) and inflammasome activation is triggered by cystine crystals.…”

Interleukin-18, CRP and procalcitonin levels in vesicoureteral reflux and reflux nephropathy

“…[4][5][6][7][8][30][31][32] An inverse correlation between IL-18 and Ccr was also demonstrated in CKD patients. 6,8 Furthermore, various reports indicated high IL-18 levels in different inflammatory situations including SLE, Adult Onset Still's Disease, inflammatory bowel disease and IgA nephropathy.…”

“…4 Moreover, it plays major role in renal ischemia-reperfusion injury and has recently become a novel biomarker of acute kidney injury (AKI). 5 Various reports indicated high levels of IL-18 and its correlation with decreased renal function in CKD patients. [6][7][8] However, it has not been studied in VUR and RN before.…”