2008
DOI: 10.1093/ndt/gfn486
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IL-18 is involved in vascular injury in end-stage renal disease patients

Abstract: The novel observations in the present study are the data indicating that the distinctive contribution of IL-18, but not IL-6, to the arteriosclerosis occurrence in CKD patients, is independent from CRP, fetuin A or other factors involved in the general inflammatory process.

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Cited by 38 publications
(36 citation statements)
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“…Our findings are in contrast with a Polish study demonstrating that hs-CRP, IL-18 and fetuin can explain the variability in PWV values in 102 subjects on renal replacement therapy compared to 30 healthy controls [7]. The authors used a similar cohort and design to the current study, however the prevalence of diabetes was lower (21 vs. 34%, respectively), and patients with a history of CVD or congestive heart failure were excluded from enrollment.…”
Section: Discussioncontrasting
confidence: 65%
See 1 more Smart Citation
“…Our findings are in contrast with a Polish study demonstrating that hs-CRP, IL-18 and fetuin can explain the variability in PWV values in 102 subjects on renal replacement therapy compared to 30 healthy controls [7]. The authors used a similar cohort and design to the current study, however the prevalence of diabetes was lower (21 vs. 34%, respectively), and patients with a history of CVD or congestive heart failure were excluded from enrollment.…”
Section: Discussioncontrasting
confidence: 65%
“…There is currently much interest in elucidating the etiology, pathogenesis and potential reversibility of arterial stiffness, so that logical strategies to reduce the high mortality rate in these individuals can be tested. There are several clinical factors associated with PWV in the CKD population [2,3], and currently investigators are starting to focus on factors leading to arterial stiffness at the molecular level [4,5,6,7,8]. This study aimed to measure a set of inflammatory, vascular and cardiac biomarkers in a cohort of CKD patients with established diabetes and/or cardiovascular disease (CVD) to describe the relationship between these biomarkers and vascular stiffness (as measured by PWV).…”
Section: Introductionmentioning
confidence: 99%
“…Future studies need to address whether medical staff should attempt to control inflammation primarily and lipids secondarily to lower rates of mortality associated with ESRD patients. Additionally, future studies should ascertain whether improvements in inflammation levels and nutritional status may help to improve clinical outcomes independent of lipid values [34]. …”
Section: Discussionmentioning
confidence: 99%
“…ESRD is characterized by a storm of inflammatory insults that are linked to many uremia-induced complications, including anemia, malnutrition, and vascular calcification (22). Vascular calcification and inflammation seem to be inextricably linked because vascular calcification results in inflammation and inflammation promotes vascular calcification (23)(24)(25). HGFIN, a growth factor initially cloned and characterized as osteoactivin in osteoblasts (1), has been identified as a regulator of macrophage activity and inflammation (12).…”
Section: Discussionmentioning
confidence: 99%