IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination

Thurner, Lorenz; Kessel, Christoph; Fadle, Natalie; Regitz, Evi; Seidel, Franziska; Kindermann, Ingrid; Lohse, Stefan; Kos, Igor; Tschöpe, Carsten; Kheiroddin, Parastoo; Kiblboeck, Daniel; Hoffmann, Michael K.; Bette, Birgit; Carbon, Gabi; Cetin, Onur; Preuss, Klaus‐Dieter; Christofyllakis, Konstantinos; Bittenbring, Joerg T.; Pickardt, Thomas; Fischer, Yvan; Thiele, Holger; Baldus, Stephan; Stangl, Karl; Steiner, Stephan; Gietzen, Frank; Kerber, Sebastian; Deneke, Thomas; Jellinghaus, Stefanie; Linke, Axel; Ibrahim, Karim; Grabmaier, Ulrich; Maßberg, Steffen; Thilo, Christian; Greulich, Simon; Gawaz, Meinrad; Mayatepek, Ertan; Meyer-Dobkowitz, Lars; Kindermann, Michael; Birk, Einat; Birk, Merav; Lainščak, Mitja; Foell, Dirk; Lepper, Philipp M.; Bals, Robert; Krawczyk, Marcin; Mevorach, Dror; Hasin, Tal; Keren, Andre; Kabesch, Michael; Abdul‐Khaliq, Hashim; Smola, Sigrun; Bewarder, Moritz; Thurner, Bernhard; Böhm, Michael; Pfeifer, John; Klingel, Karin

doi:10.1056/nejmc2205667

Cited by 61 publications

(58 citation statements)

References 3 publications

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“…In the aggregate, all of the above chemical-induced toxicities can paradoxically be in competition with each other, creating conflicting physiologic havoc at any point in time. These events also reinforce the reported linkage between volatile organic compounds and autoimmune diseases [7], and they have direct relevance to the isoform-induced autoantibody etiology of myocarditis caused by the second dose of mRNA Covid-19 vaccines [15].…”

Section: Hidden Vaccine Chemical Ingredients and Biochemical Chaossupporting

confidence: 78%

“…Detailed chronological evolution of seemingly bizarre symptoms manifested by individuals afflicted with these self-sustaining immunization reactions, coupled with the knowledge of hidden toxic vaccine ingredients, have provided important clues into mechanisms of disease causation. Other insights have been gleaned from seemingly unrelated research, including investigations into: (a) long Covid and its similarities to Covid-19 vaccination-induced disorders [3][4][5]; (b) the exacerbation of pre-existing Parkinson's disease following SARS-CoV-2 infections [6]; (c) the relationship of volatile organic compounds to autoimmunity [7]; (d) the etiology of sudden infant death syndrome [8]; (e) the demonstration of autoantibodies to autonomic and non-autonomic G protein coupled receptors (GPCRs) in long Covid, ailing Gardasil recipients, and idiopathic neurologic fatiguing syndromes (chronic fatigue syndrome/myalgic encephalomyelitis, fibromyalgia, small fiber neuropathy, dysautonomia, complex regional pain syndrome, and postural orthostatic tachycardia syndrome) [9][10][11][12]; (f) the relationship of mitochondrial quantum tunneling dysfunction to alterations in gene expression [13]; (g) the verifiable existence of breast implant illness and breast implant associated anaplastic large cell lymphoma [14]; (h) the demonstration of isoform induced autoantibodies directed against the IL-1 receptor antagonist in myocarditis precipitated by both SARS-CoV-2 infections and the second dose of mRNA Covid-19 vaccines [15]; (i) the similarities of idiopathic neurologic fatiguing syndromes to the chronic disease manifestations initiated by both Gardasil and mRNA Covid-19 immunizations [1,2]; and (j) the impacts that the 40 month-old Covid-19 pandemic has had on virtually every medical discipline (especially immunology) [16]. Despite all of these pertinent observations, many proponents of new onset vaccination-induced chronic ailments have continued to espouse controversial theories of molecular mimicry and adjuvant-induced immune stimulation as the bases for autoantibody production and disease initiation.…”

Section: Introductionmentioning

confidence: 99%

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Untitled

2023

CMPH

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The parenteral injection of hidden chemical ingredients contained in Gardasil and mRNA Covid-19 vaccines are capable of initiating a myriad of toxic biochemical disturbances. In order for these disturbances to produce chronic physical ailments they must be facilitated and amplified by several latent genetic defects, some of which allow for prolonged chemical persistence and some of which are usually considered innocuous. These "perfect storm" events may then lead to breaks in immune tolerance and the eventual production of a perplexing array of autoantibodies which, in turn, can create circuitous synergistic amplification loops to augment and chronically perpetuate the initial acute clinical phenomena. Overlapping chemical and antibody targets include G protein coupled receptors that regulate multiple autonomic and non-autonomic physiologic functions; enzymes that regulate the activities of neurotransmitters; heparan sulfate and chondroitin sulfate matrix macromolecules that bind the preformed mediators of inflammation inside mast cells, are components of sensory nerve receptors, and comprise the serine protease enzyme affinity site that cleaves BDNF into an active molecule; channel proteins regulating cell membrane ion flow in nerve conduction pathways, immunocompetent cells, and mitochondria; and the GAD 65 enzyme responsible for the production of GABA, which assists in memory, the maintenance of emotional stability, and the regulation of muscle tone and neuronal excitability. Plausible screening procedures for detecting individuals at risk for new onset vaccination-induced chronic disorders are now capable of being implemented prior to immunization. Equally important is the legitimate recognition of vaccine recipients who already manifest chronic debilitating neurologic, rheumatologic, endocrinologic, and psychologic phenomena caused by these two well-intentioned disease modifying vaccines.

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Section: Hidden Vaccine Chemical Ingredients and Biochemical Chaossupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Untitled

2023

CMPH

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“…2G), nor did they display autoantibodies against cardiac or endothelial enriched antigens or antigens previously implicated in cardiac inflammatory disorders, such as anti-B adrenoreceptor antibodies 12 . One study recently reported a high frequency of functional anti-IL1RA autoantibodies in patients with vaccineassociated myocarditis 13 . Interestingly, we did not detect IL-1RA autoantibodies in our cohort by REAP or IL-1RA ELISA (Fig.…”

Section: Resultsmentioning

confidence: 99%

SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity

et al. 2023

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AbstractmRNA-based vaccines dramatically reduce the occurrence and severity of COVID-19, but are associated with rare vaccine-related adverse effects. These toxicities, coupled with observations that SARS-CoV-2 infection is associated with autoantibody development, raise questions whether COVID-19 vaccines may also promote the development of autoantibodies, particularly in autoimmune patients. Here we used Rapid Extracellular Antigen Profiling to characterize self- and viral-directed humoral responses after SARS-CoV-2 mRNA vaccination in 145 healthy individuals, 38 patients with autoimmune diseases, and 8 patients with mRNA vaccine-associated myocarditis. We confirm that most individuals generated robust virus-specific antibody responses post vaccination, but that the quality of this response is impaired in autoimmune patients on certain modes of immunosuppression. Autoantibody dynamics are remarkably stable in all vaccinated patients compared to COVID-19 patients that exhibit an increased prevalence of new autoantibody reactivities. Patients with vaccine-associated myocarditis do not have increased autoantibody reactivities relative to controls. In summary, our findings indicate that mRNA vaccines decouple SARS-CoV-2 immunity from autoantibody responses observed during acute COVID-19.

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“…However, in a minority of cases, new onset or flare-up of autoimmune diseases may develop after COVID-19 vaccination. The precise mechanism underlying these autoimmune phenomena is currently unknown, with various postulations including molecular mimicry and cytokine surges leading to a systemic inflammatory state and more ( 4 , 5 ). Myocarditis is one of the most concerning complications associated with mRNA vaccination as it is potentially lethal ( 1 ).…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Case report: Coronavirus Disease 2019 (COVID-19) modified RNA vaccination-induced Adult-Onset Still's Disease with fulminant myocarditis as initial presentation

Zhou

Wong

Yeung

et al. 2023

Front. Cardiovasc. Med.

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Myocarditis is a rare complication of Coronavirus Disease 2019 (COVID-19) vaccination. We report a case of an elderly female who presented initially with acute myocarditis, fulminant heart failure, and atrial fibrillation after receiving a modified ribonucleic acid (mRNA) vaccine (BNT162b2). Unlike other patients with vaccine-induced myocarditis, she developed persistent fever, sore throat, polyarthralgia, diffuse macular rash, and lymphadenopathy. After extensive investigation, she was diagnosed with post-vaccination Adult-Onset Still's Disease. The systemic inflammation gradually subsided after the use of non-steroidal anti-inflammatory drugs and systemic steroids. She was discharged from hospital with stable hemodynamics. Methotrexate was subsequently given to maintain long-term remission.

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IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination

Cited by 61 publications

References 3 publications

Untitled

Untitled

SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity

RETRACTED: Case report: Coronavirus Disease 2019 (COVID-19) modified RNA vaccination-induced Adult-Onset Still's Disease with fulminant myocarditis as initial presentation

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