IL-1β +3953C/T, −511T/C and IL-6 −174C/G polymorphisms in association with tuberculosis susceptibility: A meta-analysis

Mao, Xiaogang; Ke, Zunqiong; Liu, Shuiyi; Tang, Bao-Jun; Wang, Jin; Huang, Hao; Chen, Song

doi:10.1016/j.gene.2015.07.025

Cited by 21 publications

(17 citation statements)

References 26 publications

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“…Our results suggested decreased risk for PTB development among carrier of C allele. The results corroborated previous findings among Pakistani population and confirmed by meta-analysis study [ 56 , 57 ]. It was previously demonstrated that -174G allele is associated with higher production levels of IL-6 [ 58 ].…”

Section: Discussionsupporting

confidence: 92%

“…Indeed, high levels of IL-6 cytokine are produced in response to MTB infection [ 53 , 54 ] and its role seems especially critical when bacterial burden is high [ 55 ]. Reports about the involvement of polymorphic variants within IL6 gene and PTB susceptibility remain inconsistent [ 56 ]. To provide further investigation into controversial points between IL6 polymorphisms and TB susceptibility we analyzed the influence of IL6 –174 G>C polymorphism on PTB outcome.…”

Section: Discussionmentioning

confidence: 99%

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Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population

et al. 2016

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In Mycobacterium tuberculosis (MTB) infection, the complex interaction of host immune system and the mycobacteria is associated with levels of cytokines production that play a major role in determining the outcome of the disease. Several single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with tuberculosis (TB) outcome. The aim of this study was to evaluate the association between previously reported SNPs IL2–330 T>G (rs2069762); IL4–590 C>T (rs2243250); IL6–174 G>C (rs1800795); IL10–592 A>C (rs1800872); IL10–1082 G>A (rs1800896); IL17A -692 C>T (rs8193036); IL17A -197 G>A (rs2275913); TNF -238 G>A (rs361525); TNF -308 G>A (rs1800629) and IFNG +874 T>A (rs2430561) and pulmonary TB (PTB) susceptibility. We conducted a case-control study in individuals from Southern Brazil who were recruited between February 2012 and October 2013 in a high incidence TB city. We performed a multiplex genotyping assay in 191 patients with PTB and 175 healthy subjects. Our results suggest a decreased risk for PTB development associated with the IL17A -197A allele (OR = 0.29; p = 0.04), AA genotype (OR = 0.12; p = 0.04) and A carrier (AGAA) (OR = 0.29; p = 0.004) and IL6 -174C carrier (CC/CG) (OR = 0.46; p = 0.04). We could not properly analyze IL17A -692 C>T (rs8193036) and IFNG +874T>A due to genotypic inconsistencies and found no evidence of association for the IL2, IL4, IL10 and TNF polymorphisms and PTB. In conclusion, our results show a protective effect of IL17 and IL6 polymorphisms on PTB outcome in Southern Brazilian population.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population

et al. 2016

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“…The outcome of M.tb infections depends on the production of various cytokines that recruit inflammatory cells to the areas of infection and coordinate the adaptive immune response. Although cytokine genes have a low frequency of genetic polymorphisms, an increasing number of studies have demonstrated mutations located on promoter regions or coding regions of the genes as host factors influencing susceptibility to TB (Mao et al, 2015). Polymorphisms in these genes may modify tran-scription factor recognition sites, affect transcriptional activation and alter the levels of cytokine production.…”

Section: Cytokines and Their Receptorsmentioning

confidence: 99%

Immune response gene polymorphisms in tuberculosis

et al. 2015

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Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (M.tb), remains a leading public health problem in most parts of the world. Despite the discovery of the bacilli over 100 years ago, there are still many unanswered questions about the host resistance to TB. Although one third of the world's population is infected with virulent M.tb, no more than 5-10% develop active disease within their lifetime. A lot of studies suggest that host genetic factors determine the outcome of M.tb-host interactions, however, specific genes and polymorphisms that govern the development of TB are not completely understood. Strong evidence exists for genes encoding pattern recognition receptors (TLR, CD14), C-type lectins, cytokines/chemokines and their receptors (IFN-γ, TNF-α, IL-12, IL-10, MCP-1, MMP-1), major histocompatibility complex (MHC) molecules, vitamin D receptor (VDR), and proton-coupled divalent metal ion transporters (SLC11A1). Polymorphisms in these genes have a diverse influence on the susceptibility to or protection against TB among particular families, ethnicities and races. In this paper, we review recent discoveries in genetic studies and correlate these findings with their influence on TB susceptibility.

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“…Particularly in tuberculosis, several SNPs have been reported as possible causes of disease resistance/susceptibility. Among them, there were described variations in cytokine genes such as IFN-γ, TNF-α, IL-1, IL-6, IL-10, IL-12 and IL-178910111213. However, only one study in the Argentinean population has reported the association between an IL-12 SNP and tuberculosis14.…”

mentioning

confidence: 99%

The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina

Rolandelli

Pino

Pellegrini

et al. 2017

Sci Rep

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Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new tuberculosis disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence of a human genetic component. Here, we investigated the association of the rs2275913 SNP (G → A) from IL-17A and tuberculosis in Argentina by a case-control study. Furthermore, we evaluated in vitro the functional relevance of this SNP during the immune response of the host against Mtb and analyzed its impact on clinical parameters of the disease. We found an association between the AA genotype and tuberculosis resistance. Additionally, within the healthy donors population, AA cells stimulated with a Mtb lysate (Mtb-Ag) produced the highest amounts of IL-17A and IFN-γ, which further support the genetic evidence found. In contrast, within the tuberculosis patients population, AA Mtb-Ag stimulated cells showed the lowest immunological parameters and we evidenced an association between the AA genotype and clinical parameters of disease severity, such as severe radiological lesions and higher bacilli burden in sputum. Overall, our findings demonstrated that the AA genotype from the IL-17A rs2275913 SNP is positively associated with protection to active tuberculosis but related to higher disease severity in the Argentinean population.

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IL-1β +3953C/T, −511T/C and IL-6 −174C/G polymorphisms in association with tuberculosis susceptibility: A meta-analysis

Cited by 21 publications

References 26 publications

Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population

Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population

Immune response gene polymorphisms in tuberculosis

The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina

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