IL-1β and Allergy: Focusing on Its Role in Allergic Rhinitis

Wang, Hanrui; Wei, Shi‐Zhuang; Song, Xiao‐Yu; Wang, Yao; Zhang, Wenbin; Ren, Chao; Mou, Yakui; Song, Xicheng

doi:10.1155/2023/1265449

Cited by 11 publications

(6 citation statements)

References 103 publications

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“…The top 20 targets ranked according to degree value were considered to have significant effects, including IL-1β, IL-6, TNF, IFNG, and IL-4. IL-1β has pro-inflammatory effects and is an important cytokine involved in and contributing to the development of AR, playing an important role in regulating the immune system in vitro and in vivo [ 41 ]. Meanwhile, IL-1β, a signature inflammatory factor secreted upon activation of NLRP3 inflammatory vesicles, plays a key role in the pathogenesis of AR [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanistic study of acupuncture on the pterygopalatine ganglion to improve allergic rhinitis: analysis of multi-target effects based on bioinformatics/network topology strategie

Tian,

Sun,

Mao

et al. 2024

Briefings in Bioinformatics

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One of the prevalent chronic inflammatory disorders of the nasal mucosa, allergic rhinitis (AR) has become more widespread in recent years. Acupuncture pterygopalatine ganglion (aPPG) is an emerging alternative therapy that is used to treat AR, but the molecular mechanisms underlying its anti-inflammatory effects are unclear. This work methodically demonstrated the multi-target mechanisms of aPPG in treating AR based on bioinformatics/topology using techniques including text mining, bioinformatics, and network topology, among others. A total of 16 active biomarkers and 108 protein targets related to aPPG treatment of AR were obtained. A total of 345 Gene Ontology terms related to aPPG of AR were identified, and 135 pathways were screened based on Kyoto Encyclopedia of Genes and Genomes analysis. Our study revealed for the first time the multi-targeted mechanism of action of aPPG in the treatment of AR. In animal experiments, aPPG ameliorated rhinitis symptoms in OVA-induced AR rats; decreased serum immunoglobulin E, OVA-sIgE, and substance P levels; elevated serum neuropeptide Y levels; and modulated serum Th1/Th2/Treg/Th17 cytokine expression by a mechanism that may be related to the inhibition of activation of the TLR4/NF-κB/NLRP3 signaling pathway. In vivo animal experiments once again validated the results of the bioinformatics analysis. This study revealed a possible multi-target mechanism of action between aPPG and AR, provided new insights into the potential pathogenesis of AR, and proved that aPPG was a promising complementary alternative therapy for the treatment of AR.

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Section: Discussionmentioning

confidence: 99%

Mechanistic study of acupuncture on the pterygopalatine ganglion to improve allergic rhinitis: analysis of multi-target effects based on bioinformatics/network topology strategie

Tian,

Sun,

Mao

et al. 2024

Briefings in Bioinformatics

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“…Previous studies have shown increased IL-1β in the nasal mucus of patients with AR and that it acts as a key factor in the promotion of occurrence and development of AR [71][72][73] via the ROS-NLRP3-Caspase1-IL-1β signaling pathway [74,75]. It has even been proposed that IL-1β may be a potential biomarker of AR [76]. IL-1β is immediately released from cells within 1 to 2 h after allergen exposure [77] and gradually returns to the basal concentrations after 24 h [78].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis

Krsmanović,

Arsović,

Bokonjić

et al. 2024

Biomedicines

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Background: Frequent episodes of nasal symptoms are the usual clinical manifestations (CM) of allergic rhinitis (AR) and have a significant negative impact on health-related quality of life (HRQoL) in adolescents. The purpose of this cross-sectional study was to test the hypothesis that cytokines in nasal mucus may be associated with HRQoL in adolescents with AR. Methods: European Quality of Life 5 Dimensions 3 Level Version (EQ-5D-3L), “The Adolescent Rhinoconjunctivitis Quality of Life Questionnaire” (AdolRQLQ) and the Total 4 Symptom Score (T4SS) scoring system were administered to 113 adolescents with AR, nonallergic rhinitis (NAR) and to healthy control subjects. Nasal secretions were sampled and tested for 13 cytokines using a multiplex flow cytometric bead assay. Results: The AR group had significantly lower EQ-5D-3L (0.661 ± 0.267 vs. 0.943 ± 0.088; p < 0.001) and higher AdolRQLQ total scores (2.76 ± 1.01 vs. 1.02 ± 0.10; p < 0.001) compared to the control group. The AR group had higher concentrations of IL-1β (p = 0.002), IL-6 (p = 0.031), IL-8 (p < 0.001), IL17-A (p = 0.013) and IL-18 (p = 0.014) compared to the control group, and IL-1β, IL-6, IL17-A and IL-18 were significantly (p < 0.050) increased with disease progression. Cytokines IL-1β, IL-6, as well as severe CM, were identified as significant predictors of lower HRQoL in adolescents with AR. Conclusions: This study identified IL-1β, IL-6, as well as severe CM, as predictors of lower HRQoL in adolescents with AR. However, these results should only serve as a starting point for additional confirmation research.

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“…This was also demonstrated by the results of our ELISA experiments, which were consistent with our ow cytometry results. IL-1β is a key cytokine that promotes the occurrence of AR 12 . IL-1β activates NF-κB pathway to promote IL-13 production 13 .…”

Section: Discussionmentioning

confidence: 99%

The role and mechanism of quercetin via TLR4/MyD88/IRAK4 signaling pathway in the treatment of allergic rhinitis

Kang,

Liu,

et al. 2023

Preprint

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An ovalbumin (OVA)-induced allergic rhinitis (AR) mouse model was established to investigate whether quercetin (QUE) treats AR via TLR4/MyD88/IRAK4 signaling pathway. SPF grade Balb/c mice were randomly divided into 4 groups: normal control (NC), OVA, dexamethasone (DEX), and (QUE) groups. OVA and aluminum hydroxide [AL(OH)3] were injected intraperitoneally for basic sensitization and OVA was dripped into the nose for challenge to induce a mouse model of AR. The mice were scored by observing the behaviors of scratching, sneezing and runny nose to assess whether the modeling was successful. The treatment groups (DEX and QUE) were given the corresponding drugs for gavage treatment for 1 week after successful modeling, and the OVA and NC groups were treated with normal saline instead. The levels of OVA-IgE, IL-4, IL-13, IL-1β, IL-17 and IL-10 in serum were measured by enzyme-linked immunosorbent assay (ELISA); the changes of mice nasal mucosa were observed in hematoxylin-eosin (HE) stained histopathological sections; the relative expression levels of mRNA and protein of TLR4, MyD88, IRAK4, NF-κB in lung tissues were measured by quantitative real-time PCR (qPCR) and western blot, respectively; the changes in the percentages of regulatory T cells (Treg) and helper T cells 17 (Th17) in splenocytes were detected by flow cytometry. The results showed that the allergic symptoms scores were greater than 10 points and the expression levels of OVA-IgE, IL-4, IL-13, IL-1β and IL-17 in the serum increased and the expression level of IL-10 decreased in the OVA group compared with NC group. HE staining of the nasal cavity suggested detachment and necrosis of the nasal mucosa, tissue edema, and inflammatory cell infiltration in the OVA group. The relative expression levels of mRNA and protein of TLR4, MyD88, IRAK4, NF-κB in lung tissues were increased and the percentage of Treg cells decreased and the percentage of Th17 cells increased in splenocytes of the OVA group. Based on these results, we speculate that QUE may inhibit inflammatory responses and induce immune tolerance via TLR4/MyD88/IRAK4 signaling pathway in mice model of AR.

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IL-1β and Allergy: Focusing on Its Role in Allergic Rhinitis

Cited by 11 publications

References 103 publications

Mechanistic study of acupuncture on the pterygopalatine ganglion to improve allergic rhinitis: analysis of multi-target effects based on bioinformatics/network topology strategie

Mechanistic study of acupuncture on the pterygopalatine ganglion to improve allergic rhinitis: analysis of multi-target effects based on bioinformatics/network topology strategie

The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis

The role and mechanism of quercetin via TLR4/MyD88/IRAK4 signaling pathway in the treatment of allergic rhinitis

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