IL-1β and TNF-α upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart

Gurantz, Devorah; Cowling, Randy T.; Varki, Nissi; Frikovsky, Eduardo; Moore, Cristina; Greenberg, Barry

doi:10.1016/j.yjmcc.2004.12.015

Cited by 105 publications

(90 citation statements)

References 33 publications

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“…TNF-alpha is involved in the control of angiotensin activity and, thus, in the regulation of blood pressure [18]. It has also been reported in healthy subjects that plasma levels of inflammatory cytokines, such as TNF-alpha, C-reactive protein and IL-6, are correlated with elevated blood pressure, marking them as possible risk factors in the development of hypertension [5].…”

Section: Discussionmentioning

confidence: 99%

Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet

et al. 2011

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Obesity-associated adipose tissue enlargement is characterized by an enhanced proinflammatory status and an elevated secretion of adipokines such as leptin and cytokines such as TNF-alpha. Among the different mechanisms that could underlie the interindividual differences in obesity, epigenetic regulation of gene expression has emerged as a potentially important determinant. Therefore, twenty-seven obese women (age: 32-50 years; baseline Body Mass Index, BMI: 34.4±4.2 Kg/m 2 ) were prescribed an eightweek Low-Calorie-Diet and epigenetic marks were assessed. Baseline and endpoint anthropometric parameters were measured and blood samples were drawn. Genomic DNA and RNA from adipose tissue biopsies were isolated before and after the dietary intervention. Leptin and TNF-alpha promoter methylation were measured by MSP after bisulfite treatment and gene expression was also analyzed.Obese women with a successful weight loss (≥5% of initial body weight, n=21) improved the lipid profile and fat mass percentage (-12%, p<0.05). Both systolic (-5%, p<0.05) and diastolic (-8%, p<0.01) blood pressures significantly decreased. At baseline women with better response to the dietary intervention showed lower promoter methylation levels of leptin (-47%, p<0.05) and TNF-alpha (-39%, p=0.071) than the non-responder group (n=6), while no differences were found between responder and non-responder group in leptin and TNF-alpha gene expression analysis. These data suggest that leptin and TNF-alpha methylation levels could be used as epigenetic biomarkers concerning the response to a Low-CalorieDiet. Indeed, methylation profile could help to predict the susceptibility to weight loss as well as some comorbidities such as hypertension or type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet

et al. 2011

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“…5 Contractile dysfunction and LV dilatation coincide with the peak increase of TNF-␣ after MI. 22 TNF-␣ in the infarcted area contributes to cardiomyocyte apoptosis, whereas TNF-␣ in the peri-infarct area might stimulate fibroblasts, 27 thereby stabilize the infarcted area, and attract stem cells 28 for cardiac repair and suppression of inflammation. 29 Elevated TNF-␣ in the peri-infarct area depresses contractile function, induces cardiomyocyte apoptosis, and triggers fibrosis; however, when subsequently reduced again, TNF-␣ in the peri-infarct area might contribute to preservation of contractile function.…”

Section: Are Time and Localization Of Increased Tnf-␣ Important?mentioning

confidence: 99%

Tumor Necrosis Factor-α and Its Receptors 1 and 2

Schulz

Heusch

2009

Circulation

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“…The role of cytokines in heart failure has been investigated either during the very early time period following infarction (first 48 h) (9,16) or in the advanced phase of the development of congestive heart failure (1,12,15), but very few data are available concerning the phenomena that occur in the myocardium within the first week after MI. From the literature it appears that after an initial raise in the infarcted region of the myocardium, the cytokine level decreases to return to basal values after 24 -48 h (9).…”

mentioning

confidence: 99%

“…From the literature it appears that after an initial raise in the infarcted region of the myocardium, the cytokine level decreases to return to basal values after 24 -48 h (9). Interestingly, a study by Ono et al (22) has shown that TNF-␣ gene expression peaks 1 wk after infarction in rats and decreases rapidly thereafter.…”

mentioning

confidence: 99%

Delayed expression of cytokines after reperfused myocardial infarction: possible trigger for cardiac dysfunction and ventricular remodeling

Moro

Jouan²,

Rakotovao³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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IL-1β and TNF-α upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart

Cited by 105 publications

References 33 publications

Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet

Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet

Tumor Necrosis Factor-α and Its Receptors 1 and 2

Delayed expression of cytokines after reperfused myocardial infarction: possible trigger for cardiac dysfunction and ventricular remodeling

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