IL-1β in Correlation to the Common Diabetic Complications

Karahmet, Enver; Prnjavorac, Besim; Bego, Tamer; Meseldžić, Neven; Imamović, Selma; Karahmet, Esma; Sher, Farooq; Lekic, Lana; Begić, Edin

doi:10.31080/asms.2020.05.0999

Cited by 3 publications

(1 citation statement)

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“…A commonly used explanation is oxidative stress [ 13 ]. Inflammatory cytokines have the main control in these processes because of their inflammatory promoting activity [ 14 , 15 ], which, in turn, may be related to intraoperative hypothermia [ 16 , 17 ]. However, the mechanism of how blood glucose affects thermoregulation remains unclear.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Postinduction Blood Glucose on Intraoperative Hypothermia

2023

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Background and Objectives: Hypothermia frequently occurs in patients undergoing surgery and is associated with adverse complications. Therefore, this study aimed to investigate the postinduction blood glucose and occurrence of intraoperative hypothermia in patients undergoing laparoscopic surgery. Materials and Methods: This retrospective observational study included 334 patients aged ≥20 years who had undergone elective laparoscopic surgery. The primary outcome of this study was the incidence of intraoperative hypothermia. Stratified analysis revealed differences between patients with and without diabetes. Results: Hypothermia occurred in 200 (59.9%) patients. In multivariate analysis, out-of-range postinduction glucose was independently associated with hypothermia (>150 mg/dL: odds ratio 2.17, 95% confidence interval (1.02, 4.61), p = 0.045; <110 mg/dL: odds ratio 2.02, 95% confidence interval (1.15, 3.55), p = 0.015), whereas preoperative HbA1c >6% was not significantly associated with hypothermia (odds ratio 1.02, 95% confidence interval (0.56, 1.84), p = 0.961). Considering only patients with diabetes, the incidence of hypothermia was lower (p = 0.002), the duration of hypothermia was shorter (p = 0.007), and the minimum temperature was higher (p = 0.006) in those with a postinduction glucose level of 110–150 mg/dL. Conclusions: The postinduction glucose level is independently associated with intraoperative hypothermia. Out-of-range postinduction glucose appeared to have an impact on the development of hypothermia in patients with diabetes, especially those with a postinduction glucose level <110 mg/dL.

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Section: Introductionmentioning

confidence: 99%

The Effect of Postinduction Blood Glucose on Intraoperative Hypothermia

2023

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Nanostructured Materials for Drug Delivery and Tissue Engineering Applications

et al. 2023

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Nanotechnology and nanostructured materials for drug delivery and tissue engineering applications are relatively new field that is constantly advancing and expanding. The materials used are at the nanoscale level. Recently, great discoveries and applications have been made (Agents for use in chemotherapy, biological agents and immunotherapy agents) in the treatment of diseases in various areas. Tissue engineering is based on the regeneration and repair of damaged organs and tissues by developing biological substitutes that restore, maintain or improve the function of tissues and organs. Cells isolated from patients are used to seed 3D nanoparticles that can be synthetic or natural biomaterials. For the development of new tissue in tissue engineering, it is necessary to meet the conditions for connecting cells. This paper will present the ways of connecting cells and creating new tissues. Some recent discoveries and advances in the field of nanomedicine and the application of nanotechnology in drug delivery will be presented. Furthermore, the improvement of the effectiveness of new and old drugs based on the application of nanotechnology will be shown.

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