IL-2, TNF-α, and Leptin: Local Versus Systemic Concentrations in NSCLC Patients

Carpagnano, Giovanna Elisiana; Spanevello, Antonio; Curci, Claudia; Salerno, Franco; Palladino, Grazia Pia; Resta, Onofrio; Gioia, Giuseppe Di; Carpagnano, Francesco; Barbaro, Maria Pia Foschino

doi:10.3727/000000006783980900

Cited by 76 publications

(67 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a previous study from our group (25), protein carbonylation levels, as measured by malondialdehyde (MDA)-protein adducts, were also increased in the normal epithelium of patients with LC, especially in patients with underlying COPD, whose levels were significantly greater than in those without this disease. These findings were consistent with those reported in previous investigations, in which a rise in different redox markers was demonstrated in lung tissues or blood of patients with LC (19,20,25,37,101).…”

Section: Redox Balancesupporting

confidence: 83%

“…Other cytokines and growth factors such as tumor necrosis factor (TNF)-alpha, vascular endothelial growth factor (VEGF), and transforming growth factor (TGF)-beta have also been shown to participate in the development of LC in patients with underlying respiratory conditions (30,101). Identification of additional inflammatory molecules that may be involved in the development of LC among patients with COPD and/or tumor progression is of relevance as they offer potential for the design of novel therapeutic strategies in the treatment of LC (100,102).…”

Section: Chronic Inflammationmentioning

confidence: 99%

See 1 more Smart Citation

Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Barreiro¹,

Bustamante

Curull³

et al. 2016

J. Thorac. Dis.

View full text Add to dashboard Cite

Lung cancer (LC) has become one of the leading causes of preventable death in the last few decades. Cigarette smoking (CS) stays as the main etiologic factor of LC despite that many other causes such as occupational exposures, air pollution, asbestos, or radiation have also been implicated. Patients with chronic obstructive pulmonary disease (COPD), which also represents a major cause of morbidity and mortality in developed countries, exhibit a significantly greater risk of LC. The study of the underlying biological mechanisms that may predispose patients with chronic respiratory diseases to a higher incidence of LC has also gained much attention in the last few years. The present review has been divided into three major sections in which different aspects have been addressed: (I) relevant etiologic agents of LC; (II) studies confirming the hypothesis that COPD patients are exposed to a greater risk of developing LC; and (III) evidence on the most relevant underlying biological mechanisms that support the links between COPD and LC. Several carcinogenic agents have been described in the last decades but CS remains to be the leading etiologic agent in most geographical regions in which the incidence of LC is very high. Growing evidence has put the line forward the implications of COPD and especially of emphysema in LC development. Hence, COPD represents a major risk factor of LC in patients. Different avenues of research have demonstrated the presence of relevant biological mechanisms that may predispose COPD patients to develop LC. Importantly, the so far identified biological mechanisms offer targets for the design of specific therapeutic strategies that will further the current treatment options for patients with LC. Prospective screening studies, in which patients with COPD should be followed up for several years will help identify biomarkers that may predict the risk of LC among these patients.

show abstract

Section: Redox Balancesupporting

confidence: 83%

Section: Chronic Inflammationmentioning

confidence: 99%

Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Barreiro¹,

Bustamante

Curull³

et al. 2016

J. Thorac. Dis.

View full text Add to dashboard Cite

show abstract

“…Biomarkers are originated from lower airways, but there is the possibility of saliva, upper respiratory tract contamination. To date, changes of biochemical markers of inflammation and oxidative stress have been most extensively investigated in patients with asthma (38,39), COPD (40,41), cystic fibrosis (42,43), and lung carcinoma (44) and less extensively in other pulmonary diseases (45). There is a general opinion that profiles of different analytes in EBC could be chosen in the future to help in the differential diagnosis of pulmonary diseases (16).…”

Section: Discussionmentioning

confidence: 99%

Magnesium and calcium in exhaled breath condensate of children with asthma and gastroesophageal reflux disease

Dodig

Vlašić

Čepelak

et al. 2009

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background: Magnesium and calcium physiologic functions are closely related. Magnesium is primarily an intracellular cation, the action of which also involves maintenance of cellular ionic balance, while influencing calcium homeostasis by blocking calcium channels. The aim of this study was to compare the concentrations of magnesium and calcium in exhaled breath condensate (EBC) of children with asthma and gastroesophageal reflux disease (GERD).Subjects and methods: EBC was collected from 66 children aged 7–14 years (23 children with acute asthma, 17 children with GERD, and 26 healthy children).Determination of magnesium and calciumconcentrations was preceded by optimization and validation for low concentrations.Results: No difference was recorded for either magnesium or calcium concentration between study groups. However, the magnesium to calcium ratio was statistically significantly lower in both GERD and asthma children as compared with control group.Conclusion: Study results showed the magnesium to calcium ratio to be a statistically significantly better indicator of certain pathologic changes than absolute concentration of either ion. J. Clin. Lab. Anal. 23:34–39, 2009. © 2009 Wiley‐Liss, Inc.

show abstract

“…Other studies have demonstrated that interleukin2, TNF alpha, leptin, and endothelin-1 are present in higher levels in the EBC from LC patient compared to normal controls. These levels also appeared to correlate with the stage of the disease [67][68][69]. Like VOCs, EBC still requires further validation and large scale trials.…”

Section: Exhaled Breath Condensate (Ebc)mentioning

confidence: 95%

Lung Cancer Screening: Adjuncts and Alternatives to Low-Dose CT Scans

et al. 2013

View full text Add to dashboard Cite

Lung cancer (LC) is the leading cause of cancer related mortality in US. The National Lung Screening Trial has demonstrated a mortality benefit of using low-dose computed tomography (LDCT) in the screening of LC in high-risk individuals. The US Preventive Service Task Force has given screening for LC with LDCT a grade B recommendation; however, it recognizes gaps in generalizability to the population that would qualify for screening. There are a number of new tests in various stages of evaluation and development that hold promise as adjuncts or alternatives to LDCT. The following is a review of these novel diagnostic tests.

show abstract

IL-2, TNF-α, and Leptin: Local Versus Systemic Concentrations in NSCLC Patients

Cited by 76 publications

References 2 publications

Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Magnesium and calcium in exhaled breath condensate of children with asthma and gastroesophageal reflux disease

Lung Cancer Screening: Adjuncts and Alternatives to Low-Dose CT Scans

Contact Info

Product

Resources

About