IL-26 gene variants and protein expression in Tunisian asthmatic patients

Salhi, Mariem; Tizaoui, Kalthoum; Louhaichi, S.; Lahmar, Oussama; Hamzaoui, Kamel; Hamzaoui, A.

doi:10.1016/j.cyto.2020.155206

Cited by 11 publications

(9 citation statements)

References 33 publications

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“…Previous studies have reported that increasing local IL-26 concentrations correlate with worsening disease severity in adults with asthma 5,24 . However, Salhi and colleagues did not observe a speci c correlation between systemic IL-26 concentration and markers of disease severity in adults with asthma 22 . In our study material, we observed that, amongst children with asthma, increasing systemic IL-26 levels correlate with increasing ACT scores.…”

Section: Discussionmentioning

confidence: 92%

Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen

Kovach,

Käck,

Che

et al. 2023

Preprint

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Background Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in patients with uncontrolled than in those with controlled asthma, and that this intriguing cytokine bears biomarker potential. Here, we determined how systemic IL-26 relates to allergen sensitization, asthma severity, and to IL-17A in children. Methods Serum samples were obtained from children with (n = 60) and without (n = 17) sensitization to dog allergen, and IL-26 and IL-17A protein concentrations were measured using ELISA. Self-reported history, including medication use and validated symptom-based questionnaire scores, was recorded. Results The serum concentrations of IL-26 were enhanced in allergen-sensitized subjects and correlated with those of IL-17A in a positive manner. However, the IL-26 concentrations did not markedly differ between allergen-sensitized subjects with and without asthma, eczema, allergic rhinitis, or a history of food allergy. Notably, IL-26 concentrations correlated with increasing Asthma Control Test (ACT) scores in a positive manner and with inhaled corticosteroid in a negative manner, amongst sensitized subjects with asthma. Moreover, subjects with asthma requiring ≥ 1 course of oral corticosteroids in the preceding 12 months had decreased IL-26 concentrations. Conclusion This study forwards evidence that systemic IL-26, just like IL-17A, is involved in allergen sensitization among children. The association of systemic IL-26 with improved asthma control is compatible with the cellular sources being recruited into the airways in severe asthma, which supports that this kinocidin bears potential as a biomarker and therapeutic target.

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Section: Discussionmentioning

confidence: 92%

Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen

Kovach,

Käck,

Che

et al. 2023

Preprint

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show abstract

“…Indeed, we observed that systemic protein concentrations of both IL-26 and IL-17 A are altered in a similar manner; the serum concentrations of both these cytokines are enhanced in children sensitized to dog allergen as compared to non-sensitized children. Based on prior studies demonstrating that systemic concentrations of IL-26 are enhanced in adults with asthma as compared to adults without asthma [5,24,25], we were not surprised to discover that both systemic IL-26 and IL-17 A concentrations were likewise enhanced in children sensitized to dog-allergen who also had asthma. However, we were surprised to discover that systemic IL-26 and IL-17 A concentrations did not markedly differ between sensitized children with and without asthma.…”

Section: Discussionmentioning

confidence: 98%

“…Previous studies have reported that increasing local IL-26 concentrations correlate with worsening disease severity in adults with asthma [ 5 , 22 ]. However, Salhi and colleagues did not observe a specific correlation between systemic IL-26 concentration and markers of disease severity in adults with asthma [ 24 ]. In our study material, we observed that, amongst children with asthma, increasing systemic IL-26 levels correlate with increasing ACT scores.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, amongst children with asthma, IL-26 concentrations in induced sputum were enhanced in those with uncontrolled disease as compared to those with controlled disease [ 23 ]. Conversely, other investigators found that systemic IL-26 levels are increased in adult patients with asthma as compared with non-asthmatic control subjects, regardless of disease severity or atopic status [ 24 ]. Additionally, these investigators identified IL-26 single nucleotide polymorphisms (SNPs) associated with either increased or decreased risk of developing asthma.…”

Section: Introductionmentioning

confidence: 99%

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Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen

Kovach,

Käck,

Che

et al. 2024

Respir Res

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Background Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in patients with uncontrolled than in those with controlled asthma, and that this intriguing cytokine bears biomarker potential. Here, we determined how systemic IL-26 relates to allergen sensitization, asthma severity, and to IL-17 A in children. Methods Serum samples were obtained from children with (n = 60) and without (n = 17) sensitization to dog allergen, and IL-26 and IL-17 A protein concentrations were measured using ELISA. Self-reported history, including medication use and validated symptom-based questionnaire scores, was recorded. Results The serum concentrations of IL-26 were enhanced in allergen-sensitized subjects and correlated with those of IL-17 A in a positive manner. However, the IL-26 concentrations did not markedly differ between allergen-sensitized subjects with and without asthma, eczema, allergic rhinitis, or a history of food allergy. Notably, IL-26 concentrations correlated with increasing Asthma Control Test (ACT) scores in a positive manner and with inhaled corticosteroid in a negative manner, amongst sensitized subjects with asthma. Moreover, subjects with asthma requiring ≥ 1 course of oral corticosteroids in the preceding 12 months had decreased IL-26 concentrations. Conclusion This study forwards evidence that systemic IL-26, just like IL-17 A, is involved in allergen sensitization among children. The association of systemic IL-26 with improved asthma control is compatible with the cellular sources being recruited into the airways in severe asthma, which supports that this kinocidin bears potential as a biomarker and therapeutic target.

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“…The rs7134599 A allele was associated with a lower risk of developing severe asthma, whereas the other intronic SNP rs2870946 CC genotype was correlated with a higher risk of developing asthma in smoking patients. The analysis of IL-26 SNPs and IL-26 serum levels showed no significant correlation between genotype and IL-26 production in asthmatic patients [34]. It is proposed that the effects of these SNPs on the expression of IL-26 should be investigated in future studies.…”

Section: Allergymentioning

confidence: 98%

A comprehensive review of IL‐26 to pave a new way for a profound understanding of the pathobiology of cancer, inflammatory diseases and infections

et al. 2021

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IL-26 gene variants and protein expression in Tunisian asthmatic patients

Cited by 11 publications

References 33 publications

Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen

Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen

Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen

A comprehensive review of IL‐26 to pave a new way for a profound understanding of the pathobiology of cancer, inflammatory diseases and infections

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