IL-28, IL-29 and their class II cytokine receptor IL-28R

Sheppard, Paul O.; Kindsvogel, Wayne; Xu, Wenfeng; Henderson, Katherine D.; Schlutsmeyer, Stacy; Whitmore, Theodore E.; Kuestner, Rolf E.; Garrigues, Ursula; Birks, Carl; Roraback, Jenny; Ostrander, Craig; Dong, Dennis L; Shin, Jinu; Presnell, Scott; Fox, Brian; Haldeman, Betty A.; Cooper, Emily; Taft, David W.; Gilbert, Teresa; Grant, Francis James; Tackett, Monica; Krivan, William; McKnight, Gary L.; Clegg, Christopher H.; Foster, Donald M.; Klucher, Kevin

doi:10.1038/ni873

Cited by 1,420 publications

(1,504 citation statements)

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“…However, IL28A, IL28B, and IL29, also called type 3 or lambda IFNs, are induced by viral infection and have antiviral activity. 13 All three interact with a heterodimeric class II cytokine receptor that consists of IL10Rb and IL28Ra (IFNkR1) 14,15 (Fig. 3).…”

Section: Mechanisms Of Action Of Lambda Ifns and Role Of Il28bmentioning

confidence: 99%

Hepatitis C pharmacogenetics: State of the art in 2010

Afdhal¹,

McHutchison²,

Zeuzem³

et al. 2011

Hepatology

133

104

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In 2009, a correlated set of polymorphisms in the region of the interleukin-28B (IL28B) gene were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with pegylated interferon-alfa and ribavirin. The same polymorphisms were subsequently associated with spontaneous clearance of HCV in untreated patients. The link between IL28B genotype and HCV clearance may impact decisions regarding initiation of current therapy, the design and interpretation of clinical studies, the economics of treatment, and the process of regulatory approval for new anti-HCV therapeutic agents. (HEPATOLOGY 2011;53:336-345)

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Section: Mechanisms Of Action Of Lambda Ifns and Role Of Il28bmentioning

confidence: 99%

Hepatitis C pharmacogenetics: State of the art in 2010

Afdhal¹,

McHutchison²,

Zeuzem³

et al. 2011

Hepatology

133

104

View full text Add to dashboard Cite

show abstract

“…According to the receptors that they bind, IFNs can be divided into three types: type I, type II, and type III IFNs (Sheppard et al, 2003). There are many different kinds of type I IFNs, such as IFNα, β, δ, ε , ζ, κ, τ, and ω, but type II and type III IFNs are only by a single kind each, IFNγ and IFNλ, res pectively (Pestka et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Distinct evolution process among type I interferon in mammals

Yang

Liu

2013

Protein Cell

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Interferon (IFN) is thought to play an important role in the vertebrate immune system, but systemic knowledge of IFN evolution has yet to be elucidated. To evaluate the phylogenic distribution and evolutionary history of type I IFNs, 13gen omes were searched using BLASTn program, and a phylogenetic tree of vertebrate type I IFNs was constructed. In the present study, an IFNδ-like gene in the human genome was identifi ed, refuting the concept that humans have no IFNδ genes, and other mammalian IFN genes were also identifi ed. In the phylogenetic tree, the mammalian IFNβ, IFNε, and IFNκ formed a clad e sepa rate f rom the other mammalian type I IFNs, while piscine and avian IFNs formed distinct clades. Based on this phylogenetic analysis and the various characteristics of type I IFNs, the evolutionary history of type I IFNs was further evaluated. Our data indicate that an ancestral IFNα-like gene forms a core from which new IFNs divided during vertebrate evolution. In addition, the data suggest how the other type I IFNs evolved from IFNα and shaped the complex type I IFN system. The promoters of type I IFNs were conserved among different mammals, as well as their genic regions. However, the intergenic regions of type I IFN clusters were not conserved among different mammals, demonstrating a high selec tion pressure upon type I IFNs during their evolution.

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“…They are products of 13 different genes clustered on chromosome 9, while single genes exist for IFN␤, IFN , IFN , and IFN / (7). Recently, a new class of type I IFN-like molecules with 3 members, IFN 1-3, was identified (8,9). These novel IFNs do not use the IFNAR and are therefore sometimes classified as type III IFNs.…”

Section: Introductionmentioning

confidence: 99%