IL-33: Friend or foe in transplantation?

Hassan, Ghandi F.; Cohen, Lucy S.; Alexander-Brett, Jen

doi:10.1016/j.healun.2024.02.1459

The Journal of Heart and Lung Transplantation

2024

DOI: 10.1016/j.healun.2024.02.1459

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IL-33: Friend or foe in transplantation?

Ghandi F. Hassan,

Lucy S. Cohen,

Jen Alexander-Brett

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2024

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Causal links between 13 autoimmune diseases and graft dysfunction: A Mendelian randomization study

Pan,

Zhong

2024

Medicine

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Previous studies have suggested a possible link between autoimmune diseases and graft dysfunction; however, a causal link remains unclear. Exposure factors were set as 13 autoimmune diseases, and outcomes were set as graft dysfunction. Mendelian randomization was used to analyze the causal link between exposure and outcome. Alopecia areata and asthma were linked to graft dysfunction (odds ratio 0.828; 95% confidence interval 0.699–0.980; P = .029; odds ratio 1.79; 95% confidence interval 1.069–2.996; P = .027). At the same time, primary sclerosing cholangitis was found to be heterogeneous as an exposure factor (P = .009), but no heterogeneity or pleiotropy was found in other exposure factors. Our preliminary findings show 2 autoimmune diseases as risk factors for graft dysfunction, 1 autoimmune disease as a protective factor for graft dysfunction and the mechanisms remain to be understood.

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Causal links between 13 autoimmune diseases and graft dysfunction: A Mendelian randomization study

Pan,

Zhong

2024

Medicine

View full text Add to dashboard Cite

show abstract

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IL-33: Friend or foe in transplantation?

Cited by 1 publication

References 70 publications

Causal links between 13 autoimmune diseases and graft dysfunction: A Mendelian randomization study

Causal links between 13 autoimmune diseases and graft dysfunction: A Mendelian randomization study

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