IL-33 Promotes Gastric Cancer Cell Invasion and Migration Via ST2–ERK1/2 Pathway

Abstract

IL-33 promotes gastric cancer cell invasion and migration by stimulating the secretion of MMP-3 and IL-6 via ST2-ERK1/2 pathway. Thus, IL-33 may be a useful marker for the diagnosis and treatment of gastric cancer.

Increased Soluble Suppression of Tumorigenicity 2 Level Predicts All-Cause and Cardiovascular Mortality in Maintenance Hemodialysis Patients: A Prospective Cohort Study

“…Considering the disparity that exists in dialysis practice across different regions and introduction of new treatment modalities, the results obtained from this single-center study require validation in external population. Second, it is clear that IL-33/ST2 signaling participates in the immune response of numerous diseases, such as rheumatoid arthritis [27] , asthma [28] , malignancy [29,30] and vasculitis [31] . Underlying malig-nancy and immune alteration in study participants may be potential confounders.…”

Wounds that heal and wounds that don’t − The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis

“…In head and neck squamous cell carcinoma (HNSCC), it has been shown that administration of IL-33 promoted cancer cell migration and invasion through induction of epithelial-mesenchymal transition [97]. Recently, it has been suggested that IL-33 can promote gastric cancer cell invasion and migration, which was suggested to be mediated by activation of ERK1/2 [98]. Other studies, however, have shown divergent anti-tumorigenic effects of IL-33 and ST2 in cancer.…”

Targeting IL-33 in Autoimmunity and Inflammation

“…Some authors have reported that IL-33 promotes metastasis of gastric (Yu et al, 2015) and colorectal cancers. However, other papers have reported that IL-33 may act as an adjuvant to enhance antigen-specific tumor immunity .…”