IL-37 inhibits lipopolysaccharide-induced osteoclast formation and bone resorption in vivo

Saeed, Jafari; Kitaura, Hideki; Kimura, Keisuke; Ishida, Masahiko; Sugisawa, Haruki; Ochi, Yumiko; Kishikawa, Akiko; Takano‐Yamamoto, Teruko

doi:10.1016/j.imlet.2016.04.004

Cited by 33 publications

(39 citation statements)

References 38 publications

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“…IL-6 is be-lieved to promote osteoclast differentiation and activation, which are involved in various metabolic bone diseases including postmenopausal osteoporosis (Al-Daghri et al, 2014). IL-1 is another potent stimulator of bone resorption, accelerating bone loss (Saeed et al, 2016). Although TNF-α has not been directly linked to osteoporosis or bone loss, anti-TNF-α drugs could be used to treat bone loss and inflammatory processes (Saidenberg-Kermanac'h, Cohen-Solal, Bessis, De Vernejoul, & Boissier, 2004;Zheng et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Anti‐Disuse Osteoporosis Activity of a Complex of Calcium‐Binding Peptide from Auricularia auricula Protein Hydrolysates

Gao

et al. 2019

Journal of Food Science

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Osteoporosis is a common metabolic bone disease that is often seen in bedridden patients and astronauts. Long‐term bed rest and nonweight bearing tend to induce disuse osteoporosis. Calcium supplements are commonly used to help treat disuse osteoporosis along with medications, most of which are calcium carbonate based, but they have poor absorption effects. In this study, we prepared a novel Auricularia auricula peptide–calcium complex (AP–Ca) and evaluated its protective effects on disuse osteoporosis. In vitro assays showed that AP–Ca significantly increased the contents of calcium (P < 0.05) and the activity of alkaline phosphatase (AKP; P < 0.05) of osteoblasts cultured in a two‐dimensional‐rotating wall vessel. Meanwhile, supplementation with AP–Ca also inhibited the production of pro‐inflammatory factors induced by the loss of stress, especially TNF‐α (P < 0.05). In vivo, a mouse tail suspension (TS) model was established, and the results showed that AP–Ca helped to improve bone mineral density, bone mineral content, and bone organic content in TS mice and effectively alleviated the alteration of enzymes related to bone metabolism, including AKP (P < 0.05) and serum tartrate‐resistant acid phosphatase (P < 0.05), to avoid more serious bone loss induced by TS. Furthermore, we found that AP–Ca downregulated the bone resorption‐associated pro‐inflammatory genes interleukin‐1 (IL‐1), tumor necrosis factor‐α, and IL‐6 by 59.53 ± 3.55%, 48.01 ± 5.68%, and 40.00 ± 5.89%, respectively (P < 0.05). In conclusion, AP–Ca showed potential to suppress bone loss induced by disuse and might be considered a new alternative to reduce the risk of disuse osteoporosis. Practical Application This peptide–calcium complex supplement exhibited protective effects on the bone loss induced by disuse, which provided a new alternative for patients and astronauts to reduce the risk of disuse osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Anti‐Disuse Osteoporosis Activity of a Complex of Calcium‐Binding Peptide from Auricularia auricula Protein Hydrolysates

Gao

et al. 2019

Journal of Food Science

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“…TRAP-positive cells with ≥3 nuclei were considered to be osteoclasts. The number of TRAP-positive cells was counted and averaged within the sagittal sutures of each coronal part in all slides according to our previous report [33]. In addition, the percentage of interface of bone marrow space covered by osteoclasts and the number of osteoclast at interface of bone marrow space were measured.…”

Section: Histological Analysismentioning

confidence: 99%

IL-33 Inhibits TNF-α-Induced Osteoclastogenesis and Bone Resorption

Ohori

Kitaura

Ogawa

et al. 2020

IJMS

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Interleukin (IL)-33 is a member of the IL-1 family, which acts as an alarmin. Several studies suggested that IL-33 inhibited osteoclastogenesis and bone resorption. Tumor necrosis factor-α (TNF-α) is considered a direct inducer of osteoclastogenesis. However, there has been no report regarding the effect of IL-33 on TNF-α-induced osteoclastogenesis and bone resorption. The objective of this study is to investigate the role of IL-33 on TNF-α-induced osteoclastogenesis and bone resorption. In an in vitro analysis of osteoclastogenesis, osteoclast precursors, which were derived from bone marrow cells, were treated with or without IL-33 in the presence of TNF-α. Tartrate-resistant acid phosphatase (TRAP) staining solution was used to assess osteoclast formation. In an in vivo analysis of mouse calvariae, TNF-α with or without IL-33 was subcutaneously administrated into the supracalvarial region of mice daily for 5 days. Histological sections were stained for TRAP, and osteoclast numbers were determined. Using micro-CT reconstruction images, the ratio of bone destruction area on the calvariae was evaluated. The number of TRAP-positive cells induced by TNF-α was significantly decreased with IL-33 in vitro and in vivo. Bone resorption was also reduced. IL-33 inhibited IκB phosphorylation and NF-κB nuclear translocation. These results suggest that IL-33 inhibited TNF-α-induced osteoclastogenesis and bone resorption.

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“…With the decline in edentulism and the increasing geriatric population, prosthodontic needs will continue to increase. 11,13…”

Section: Trends In Dental Services For the Elderlymentioning

confidence: 99%

“…If there is an imbalance between the formation and resorption of the bone causing excessive bone resorption, the formation of bone height, density or both becomes reduced. [10][11][12]14 Resorption of the alveolar bone is showed in Fig. 2, thought to have occurred when the peaks of alveolar bone (alveolar crest) are 2 mm or more higher than the cement-enamel junction.…”

Section: Alveolar Bone Resorptionmentioning

confidence: 99%

“…However, more frequent resorption of bone in the oral cavity occurs after bacterial infections, such as periodontitis, or as a result of tooth loss (edentulous), where residual ridge resorption (RRR) will be faster and more progressive. 11,13 The following are some of the etiologies that cause alveolar bone resorption: atrophy, trauma and infection, loss of periodontal tissue due to tooth extraction, hyperparatiroidism and hypogonadism, and bone resorption due to osteoporosis. Resorption of alveolar bone in periodontitis (Fig.…”

Section: Alveolar Bone Resorptionmentioning

confidence: 99%

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The Prosthodontics Care For Geriatric Patients Nowadays

Oktaria

Shen

2019

JIDA

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The global geriatric (elderly) population is growing as a result of increasing life expectancies. One impact of this development is an increase of lifestyle difference. In the scope of health, especially dental health, the patient’s education is important. The decrease in edentulism cases showsed public awareness of the importance in maintaining the health, function and quality of life in the elderly as well as the necessity of preventive attitudes and interventions against disease. Dental services for geriatric patients are affected by the cost of dental services, dental insurance, dental clinics’ access, debt and needs. The current prosthodontic treatment that improve of missing tooth replacements is in demand is an increasing interest in dental implant treatment. Losing tooth has a negative impact on mastication, aesthetic- and oral health-related quality of life. Excessive bone resorption can occur for many reasons, including age, infection, trauma, metabolic disorders and nutritional deficiencies. The resorption of the alveolar bone, especially in medically compromised patients, is caused by focal infections in the mouth and systemic diseases. Periodontitis or other chronic infections resulted from bacterial and host inflammatory cells. The pathology observation can result in a loss of bone support after a long period of extraction procedures is named residual ridge resorption (RRR). The best treatment for RRR is to avoid tooth extraction so that the loss of teeth and their supportive tissues can be prevented. When there is a loss of teeth and RRR, dentures have been made to reduce the occlusal load are necessary. In addition, the importance of periodic control, utilizing vitamins, oral rinse, topical gels or others, and the intake of nutrients greatly affect the good function of dentures and improve the health of the geriatric patient.

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IL-37 inhibits lipopolysaccharide-induced osteoclast formation and bone resorption in vivo

Cited by 33 publications

References 38 publications

Anti‐Disuse Osteoporosis Activity of a Complex of Calcium‐Binding Peptide from Auricularia auricula Protein Hydrolysates

Anti‐Disuse Osteoporosis Activity of a Complex of Calcium‐Binding Peptide from Auricularia auricula Protein Hydrolysates

IL-33 Inhibits TNF-α-Induced Osteoclastogenesis and Bone Resorption

The Prosthodontics Care For Geriatric Patients Nowadays

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