IL-4 enhances interferon production by virus-infected human mast cells

Portales‐Cervantes, Liliana; Crump, Owen M.; Dada, Sarah; Liwski, Christopher R.; Gotovina, Jelena; Haidl, Ian D.; Marshall, Jean S.

doi:10.1016/j.jaci.2020.02.011

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…This is based on the observation that IL-4 enhanced virus-induced IFN production by mast cells, and this phenomenon was augmented by IgE-mediated activation. 68 Hence, IFNs detected in nasal washes in the present study likely reflect the culmination of complex regulatory mechanisms that differ according to cell type and context, and cannot be predicted on the basis of in vitro systems.…”

Section: Discussionmentioning

confidence: 71%

Human TH1 and TH2 cells targeting rhinovirus and allergen coordinately promote allergic asthma

Muehling

Heymann

Wright

et al. 2020

Journal of Allergy and Clinical Immunology

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Background: Allergic asthmatic subjects are uniquely susceptible to acute wheezing episodes provoked by rhinovirus. However, the underlying immune mechanisms and interaction between rhinovirus and allergy remain enigmatic, and current paradigms are controversial. Objective: We sought to perform a comprehensive analysis of type 1 and type 2 innate and adaptive responses in allergic asthmatic subjects infected with rhinovirus. Methods: Circulating virus-specific T H 1 cells and allergenspecific T H 2 cells were precisely monitored before and after

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Section: Discussionmentioning

confidence: 71%

Human TH1 and TH2 cells targeting rhinovirus and allergen coordinately promote allergic asthma

Muehling

Heymann

Wright

et al. 2020

Journal of Allergy and Clinical Immunology

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“… 49 Similarly, IL-4 treatment of human mast cells has also been shown to increase type 1 interferon responses to mucosal viral infection. 50 The mechanisms associated with the initial delay in type 1 interferons are unclear, but could be related to other type 2 inflammatory features such as IgE and blood eosinophilia. Indeed, others have shown IgE-mediated 51 and eosinophil-mediated 52 suppression of interferon responses in plasmacytoid dendritic cells, which typically release significant concentrations of IFN-α on viral encounter.…”

Section: Discussionmentioning

confidence: 99%

Dysfunctional neutrophil type 1 interferon responses in preschool children with recurrent wheezing and IL-4–mediated aeroallergen sensitization

Fitzpatrick,

Huang,

Mohammad

et al. 2024

Journal of Allergy and Clinical Immunology: Global

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“…MCs are granulated leukocytes [ 12 ] that reside in mucosal interfaces in close contact with the environment to respond to environmental challenges [ 13 ] and infectious organisms [ 14 , 15 , 16 ]. Recent studies showed that MCs are key effector cells of the innate immune system, and during viral infections they release several inflammatory mediators and cytokines, including histamine and IL-6 [ 17 , 18 ]. Histamine can contribute to the progression of inflammatory responses in many cell types and local tissues by enhancing the secretion of pro-inflammatory cytokines, such as IL-1α, IL-1β, IL-6, and chemokine (C-C motif) ligand 3 (CCL3) [ 19 ].…”

Section: Mast Cell (Mc) Responses To Sars-cov-2 May Promote Cytokine Stormsmentioning

confidence: 99%

Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast Cells

Kazemi

Chan

Knapp

et al. 2021

Cells

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Cytokine storm syndrome is a cascade of escalated immune responses disposing the immune system to exhaustion, which might ultimately result in organ failure and fatal respiratory distress. Infection with severe acute respiratory syndrome-coronavirus-2 can result in uncontrolled production of cytokines and eventually the development of cytokine storm syndrome. Mast cells may react to viruses in collaboration with other cells and lung autopsy findings from patients that died from the coronavirus disease that emerged in 2019 (COVID-19) showed accumulation of mast cells in the lungs that was thought to be the cause of pulmonary edema, inflammation, and thrombosis. In this review, we present evidence that a cytokine response by mast cells may initiate inappropriate antiviral immune responses and cause the development of cytokine storm syndrome. We also explore the potential of mast cell activators as adjuvants for COVID-19 vaccines and discuss the medications that target the functions of mast cells and could be of value in the treatment of COVID-19. Recognition of the cytokine storm is crucial for proper treatment of patients and preventing the release of mast cell mediators, as impeding the impacts imposed by these mediators could reduce the severity of COVID-19.

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IL-4 enhances interferon production by virus-infected human mast cells

Cited by 8 publications

References 12 publications

Human TH1 and TH2 cells targeting rhinovirus and allergen coordinately promote allergic asthma

Human TH1 and TH2 cells targeting rhinovirus and allergen coordinately promote allergic asthma

Dysfunctional neutrophil type 1 interferon responses in preschool children with recurrent wheezing and IL-4–mediated aeroallergen sensitization

Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast Cells

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