IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma

Th2 Cell-Selective Enhancement of HumanIL13Transcription byIL13-1112C>T, a Polymorphism Associated with Allergic Inflammation

“…Indeed, asthma risk was 5-fold higher in carriers of IL13-1112T and IL4RA 478Ser (43), compared with individuals with both nonrisk genotypes, and the effects of the IL13-1112TT genotype on risk for food sensitization were modified by IL4RA S478P and IL4RA Q155R (17). Risk for high IgE and asthma was increased even further by the combination of IL13-1112CϾT, IL4-589CϾT, IL4RA-148AϾG and STAT6 IL4RA-2892CϾT (44).…”

Quality of Life and Health Outcomes in Overweight and Non-Overweight Children With Asthma

“…The obvious role genetics play in the development of asthma and the ability to map the human genome has lead to numerous studies focusing on this relationship (Apter Table 2, recent studies using genome mapping suggest that susceptibility to asthma is determined by many genes (Kabesch et al, 2006;Tattersfield et al, 2002). Over 22 loci on 15 autosomal chromosomes have been linked to asthma (Liu et al, 2004).…”

“…Over 22 loci on 15 autosomal chromosomes have been linked to asthma (Liu et al, 2004). The hope for the future is that genetic markers can be used as a screening tool for development of childhood asthma and be used to predict an individual's response to different asthma medication options (Kabesch et al, 2006;Liu et al, 2004). Table 2.…”

The era of genome-wide association studies: opportunities and challenges for asthma genetics

“…40 Further complexity relates to gene-by-gene interactions. 41 If the given genetic variant delivers a different effect size when different co-dominant genes are present, a population consisting of several subpopulations with different co-existent genes will present a mean effect size in that population, which is not expected to be replicated in other populations. These scenarios are more likely to be true for asthma, as many unknown environmental factors and multiple candidate genes interact in contributing to its susceptibility.…”