IL-4, IL-6, IL-10, IL-17A and vascular endothelial growth factor in the vitreous of patients with proliferative diabetic retinopathy

Черных, В. В.; Smirnov, Evgeny; Varvarinsky, Yegor; Черных, Д. В.; Обухова, О. О.; Трунов, А. Н.

doi:10.4236/abb.2014.53023

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…A patogênese do diabetes mellitus é vista como um processo multifatorial (CHERNYKH et al, 2014). Essa patogenicidade ocasiona distúrbios metabólicos vasculares locais e sistêmicos as quais levam ao aparecimento de lesões na visão (CHERNYKH et al, 2014).…”

Section: Citocinas Inflamatórias Envolvidas Na Retinopatia Diabéticaunclassified

Análise Sobre a Eficácia Da Meditação No Tratamento De Distúrbios De Ansiedade

Pereira¹,

Oliveira²,

Duarte³

et al. 2020

Propostas, Recursos E Resultados Nas Ciências Da Saúde 3

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Section: Citocinas Inflamatórias Envolvidas Na Retinopatia Diabéticaunclassified

Análise Sobre a Eficácia Da Meditação No Tratamento De Distúrbios De Ansiedade

Pereira¹,

Oliveira²,

Duarte³

et al. 2020

Propostas, Recursos E Resultados Nas Ciências Da Saúde 3

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Importance of the Use of Oxidative Stress Biomarkers and Inflammatory Profile in Aqueous and Vitreous Humor in Diabetic Retinopathy

et al. 2020

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Diabetic retinopathy is one of the leading causes of visual impairment and morbidity worldwide, being the number one cause of blindness in people between 27 and 75 years old. It is estimated that ~191 million people will be diagnosed with this microvascular complication by 2030. Its pathogenesis is due to alterations in the retinal microvasculature as a result of a high concentration of glucose in the blood for a long time which generates numerous molecular changes like oxidative stress. Therefore, this narrative review aims to approach various biomarkers associated with the development of diabetic retinopathy. Focusing on the molecules showing promise as detection tools, among them we consider markers of oxidative stress (TAC, LPO, MDA, 4-HNE, SOD, GPx, and catalase), inflammation (IL-6, IL-1ß, IL-8, IL-10, IL-17A, TNF-α, and MMPs), apoptosis (NF-kB, cyt-c, and caspases), and recently those that have to do with epigenetic modifications, their measurement in different biological matrices obtained from the eye, including importance, obtaining process, handling, and storage of these matrices in order to have the ability to detect the disease in its early stages.

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Effect of atorvastatin on diabetic rat endothelial cells and retinal lesions

Bi¹,

Song²,

Shang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT.We investigated the effect of atorvastatin on vascular endothelial growth inhibitor (VEGI) expression in rats with diabetic retinopathy. Wistar rats were divided into a blank group and diabetic model group, which was further randomly divided into treatment and control groups. Rats in the treatment group received 10 mg/kg atorvastatin daily, while rats in the blank and control groups received normal saline. Rats were randomly euthanized at 3 or 6 months. Immunohistochemical staining was used to determine changes in VEGI and vascular endothelial growth factor, interleukin-4, and tumor necrosis factor α levels in rats with diabetic retinopathy. Survival rate in the treatment group was 84% (63/75) after 6 months, which was significantly higher than that in the control group (P < 0.05); rats in the control group showed the lowest survival rate. Survival in the treatment group was higher than that in the control group but not significant compared with the blank group after 3 months. VEGI, vascular endothelial growth factor, tumor necrosis factor α, and interluekin-4 expression was lower than that in the control group, but higher than the blank group after 3 months. The (2015) expression of each factor decreased to the blank group level in the treatment group and was significantly lower than that in the control group after 6 months (P < 0.05). Expression in control and blank groups was similar at 3 and 6 months. Atorvastatin can inhibit VEGI and vascular endothelial growth factor expression to protect rats from diabetic retinopathy.

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IL-4, IL-6, IL-10, IL-17A and vascular endothelial growth factor in the vitreous of patients with proliferative diabetic retinopathy

Cited by 3 publications

References 18 publications

Análise Sobre a Eficácia Da Meditação No Tratamento De Distúrbios De Ansiedade

Análise Sobre a Eficácia Da Meditação No Tratamento De Distúrbios De Ansiedade

Importance of the Use of Oxidative Stress Biomarkers and Inflammatory Profile in Aqueous and Vitreous Humor in Diabetic Retinopathy

Effect of atorvastatin on diabetic rat endothelial cells and retinal lesions

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