IL-4 inducibility in NKT cells, naïve CD4+ T cells and TCR-γ δ T cells

Chen, Yi-Ting; Kung, John T.

doi:10.1007/s11373-007-9167-1

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Besides stimulating effector T cells, IL-2 also mediates the development and homeostasis of Tregs [18]. IL-4 acts as a growth factor for Th2 cells and a co-stimulator of DNA-synthesis and induces the expression of class II MHC molecules on resting B-cells [19–21]. Although sharing many functions with IL-2, IL-15 has distinct functions in vivo.…”

Section: Discussionmentioning

confidence: 99%

Expression Pattern of Serum Cytokines in Hepatitis B Virus Infected Patients with Persistently Normal Alanine Aminotransferase Levels

Guo

et al. 2013

J Clin Immunol

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PurposeAbout 60–80 % of chronic hepatitis B virus (HBV) carriers are characterized with persistently normal alanine transaminase (ALT). Differences of cytokine expression are associated with the prognosis of HBV infection. We investigated the expression pattern of 30 cytokines associated with anti-HBV immunity in patients with normal ALT.MethodsFour patient groups (immune tolerance, inactive hepatitis B surface antigen carriers, resolved hepatitis B, and control; 10 subjects per group) were assigned. Thirty cytokines, including IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-7, IL-9, IL-10, IL-12p40, IL-12p70, IL-15, IL-17A, IL-17C, IL-21, IL-22, IL-23p19, IL-28A, IL-29, CCL5, CCL16, CCL20, CCL22, CXCL9, CXCL10, CXCL11, TNFRSF8, TNFRSF18, IL-6R, gp130, and TGF-β1, were measured using a human cytokine antibody array. Signal intensities were obtained by laser scanner. Protein-protein interactions were analyzed by STRING (Search Tool for the Retrieval of Interacting Genes/Proteins).ResultsSignificant differences of signal intensities were observed for IL-2, IL-4, IL-6, IL-7, IL-9, IL-10, IL-12p40, IL-12p70, IL-15, IL-21, IL-23p19, IL-28A, and IL-29. The lowest intensity was in controls. Among three HBV infection groups, significant differences were observed in IL-2, IL-4, IL-12p70, IL-15, IL-21, IL-23p19, and IL-29. The highest intensity was in the inactive group. All cytokines with significant differences were involved JAK-STAT signaling that up-regulate FOXP3, SOCS3 and MX1.ConclusionDifferential expression of cytokines in JAK-STAT signaling is an important factor associated with prognosis of HBV infection. The elevation of γC cytokines, IL-12p70, IL-23p19, and IL-29 may promote spontaneous HBeAg seroconversion and HBV clearance.Electronic supplementary materialThe online version of this article (doi:10.1007/s10875-013-9931-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Expression Pattern of Serum Cytokines in Hepatitis B Virus Infected Patients with Persistently Normal Alanine Aminotransferase Levels

Guo

et al. 2013

J Clin Immunol

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“…IL‐4 is produced primarily by CD4+ cells and NK cells after stimulation. It is a pleiotropic cytokine best known for its ability to direct antigen‐activated T cells to differentiate into T H 2 cells (28). Neonatal immune responses are dominated by T H 2 cytokines, and the development of the child's immune system toward adult‐like T H 1 cytokine production progresses over time in both healthy (29) and atopic infants (30).…”

Section: Discussionmentioning

confidence: 99%

Effect of Feeding a Formula Supplemented With Long‐chain Polyunsaturated Fatty Acids for 14 Weeks Improves the Ex Vivo Response to a Mitogen and Reduces the Response to a Soy Protein in Infants at Low Risk for Allergy

Field

Aerde

Goruk

et al. 2010

J. pediatr. gastroenterol. nutr.

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Scrophularia buergerianaregulates cytokine production in vitro

Kim¹,

Park²,

Myung³

et al. 2009

Immunopharmacology and Immunotoxicology

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The Scrophularia buergeriana (SB) has long been used to treat various diseases an account of its antimicrobial and anti-virus activity. However, it is unclear how SB regulates the immune responses. This study investigated the effect of SB on the production of cytokines in a human T-cell line, MOLT-4 cells, and mouse peritoneal macrophages. The MOLT-4 cells were cultured for 24 h in the presence or absence of SB plus concanavalin (con) A. SB plus con A significantly increased the level of interleukin (IL)-2, IL-4 and interferon (IFN)-gamma production compared with that of con A alone (approximately 1.79-fold for IL-2, 2-fold for IL-4, and 1.85-fold for IFN-gamma, p < 0.05). SB plus recombinant IFN-gamma (rIFN-gamma) increased the level of IL-12 and NO production compared with rIFN-gamma alone. In addition, SB plus rIFN-gamma increased the level the iNOS expression on mouse peritoneal macrophages. Overall, SB may have an immune-enhancement effect through cytokine production.

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IL-4 inducibility in NKT cells, naïve CD4+ T cells and TCR-γ δ T cells

Cited by 3 publications

References 32 publications

Expression Pattern of Serum Cytokines in Hepatitis B Virus Infected Patients with Persistently Normal Alanine Aminotransferase Levels

Expression Pattern of Serum Cytokines in Hepatitis B Virus Infected Patients with Persistently Normal Alanine Aminotransferase Levels

Effect of Feeding a Formula Supplemented With Long‐chain Polyunsaturated Fatty Acids for 14 Weeks Improves the Ex Vivo Response to a Mitogen and Reduces the Response to a Soy Protein in Infants at Low Risk for Allergy

Scrophularia buergerianaregulates cytokine production in vitro

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