2015
DOI: 10.1016/j.jinf.2014.10.009
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IL-4 specific-response in whole blood associates with human Cystic Echinococcosis and cyst activity

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Cited by 35 publications
(53 citation statements)
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“…Cytokines have been considered the basis of potential tools for the diagnosis and clinical management of CE, and associations between cytokine responses and some clinical features have been reported . In this context, we recently set up an immune‐based test measuring the IL‐4 production after stimulating whole blood with an enriched fraction of antigen B (AgB—the most abundant antigen of HCF) or AgB peptides . In this whole‐blood test, higher levels of IL‐4 associated with CE infection (71.4% sensitivity, 93.3% specificity) and with the presence of active cysts (84.6% sensitivity, 92% specificity) .…”
Section: Introductionmentioning
confidence: 99%
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“…Cytokines have been considered the basis of potential tools for the diagnosis and clinical management of CE, and associations between cytokine responses and some clinical features have been reported . In this context, we recently set up an immune‐based test measuring the IL‐4 production after stimulating whole blood with an enriched fraction of antigen B (AgB—the most abundant antigen of HCF) or AgB peptides . In this whole‐blood test, higher levels of IL‐4 associated with CE infection (71.4% sensitivity, 93.3% specificity) and with the presence of active cysts (84.6% sensitivity, 92% specificity) .…”
Section: Introductionmentioning
confidence: 99%
“…In this context, we recently set up an immune‐based test measuring the IL‐4 production after stimulating whole blood with an enriched fraction of antigen B (AgB—the most abundant antigen of HCF) or AgB peptides . In this whole‐blood test, higher levels of IL‐4 associated with CE infection (71.4% sensitivity, 93.3% specificity) and with the presence of active cysts (84.6% sensitivity, 92% specificity) . However, cross‐reactivity with AE has not been tested.…”
Section: Introductionmentioning
confidence: 99%
“…M(IL-4) activation and macrophage proliferation in E. granulosus infection have not yet been analysed. However, they are relevant issues considering the importance of IL-4 in the immune response of natural and experimental hosts in this infection282930. Thus, we aimed to elucidate the relationships between exposure to LL particles, macrophage proliferation, and M(IL-4) activation.…”
mentioning
confidence: 99%
“…The antibody levels significantly decreased over the course of antiparasitic therapy in sera from patients with cured disease, when compared to sera from patients with progressive disease. Petrone et al [28] found that interleukin-4 levels were significantly increased in patients with active cysts compared to those with inactive cysts. Once we don't have an immunological method to confirm the cyst inactivity and guarantee the cure of this disease, we only can evaluate the therapeutic efficacy by imaging methods.…”
Section: Resultsmentioning
confidence: 99%