IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease

Li, L; Li, E; Zhang, L H; Jian, Liguo; Liu, H P; Wang, T

doi:10.4238/2015.july.28.12

Cited by 25 publications

(24 citation statements)

References 25 publications

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“…Several previous studies reported an association between IL-10-1082A/G polymorphism and the development of coronary artery diseases; however, the results were inconclusive (Guo et al, 2012;Elsaid et al, 2014;Li et al, 2015;Ren and She, 2015). Li et al (2015) conducted a case-control study in the Chinese population and did not find any association between IL-10-1082A/G polymorphism and the risk of coronary artery diseases.…”

Section: Discussionmentioning

confidence: 97%

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Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population

2016

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ABSTRACT. We conducted a case-control study to investigate the association between IL-10-G1082A (rs1800896) polymorphism and the development of coronary artery disease (CAD) in the Chinese population. We recruited 295 CAD patients and 355 healthy controls from the Fifth Affiliated Hospital of Zhengzhou University between April 2012 and December 2014. Subjects were genotyped for IL-10-G1082A polymorphisms by using polymerase chain reaction-restriction fragment length polymorphism. We observed significant differences in the genotype frequencies of GG, AG, and AA between CAD patients and controls (c 2 = 17.38, P < 0.001). Multivariate logistic regression analyses revealed that individuals with the AA genotype at IL-10-1082A/G was associated with increased risk for CAD as compared to those with the GG genotype (OR = 2.96, 95%CI = 1.70-5.23, P < 0.001). Our results indicated that IL-10 -1082A/G polymorphism was associated with susceptibility to CAD in both dominant (OR = 1.59, 95%CI = 1.15-2.20, P = 0.004) and recessive (OR = 2.58, 95%CI = 1.53-4.45, P < 0.001) models. In conclusion, our study suggests that IL-10-1082A/G polymorphism is associated with an increased risk for CAD.

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Section: Discussionmentioning

confidence: 97%

“…Li et al (2015) conducted a case-control study in the Chinese population and did not find any association between IL-10-1082A/G polymorphism and the risk of coronary artery diseases. Similarly, Guo et al (2012) reported that IL-10-1082A/G polymorphism is unlikely to be associated with CAD.…”

Section: Discussionmentioning

confidence: 99%

Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population

2016

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“…The development of CAD is involved in multiple lifestyle and environment-related factors and their interactions, such as high age, males, high dietary sugar, alcohol use, tobacco smoking, hypertension, diabetes, obesity, low high-density lipoprotein, as well as family history of CAD (Go et al, 2013). Additionally, genetic factors play an important role in increased risk of CAD development, and previous studies have indicated that many genes are correlated with this cancer, such as vitamin D receptor gene, interleukin-17 (IL-17), IL-6, apolipoprotein A5 (APOA5), cyclooxygenase-2 (COX-2), matrix metalloproteinase-2 (MMP-2) and 7-Alpha cholesterol hydroxylase (CYP7A1) (Abu et al, 2015;Geng et al, 2015;Iwanicki et al, 2015;Li et al, 2015;Shi et al, 2015b;Xia et al, 2015;Zhang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Inflammation plays an important role in CAD pathogenesis, such as IL-6, IL-1β, IL-8, and IL-17 genetic polymorphisms are associated with susceptibility to CAD (Geng et al, 2015;Li et al, 2015;Yang et al, 2015). IL-10 is a member of the immunoregulatory cytokine family, and is located on chromosome 1q31-1q32.…”

Section: Introductionmentioning

confidence: 99%

Statistical analysis of the relationship between IL-10 gene promoter polymorphisms and the development of coronary artery disease

Zhao

Geng

et al. 2016

Genet. Mol. Res.

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“…Так, при исследованиях, проводимых среди лиц ази-атской популяции, было установлено, что полимор-физмы 174G/C, С572G, ОНП rs8034928 и rs11556218 гена IL-6 статистически значимо связаны с повы-шенным риском ИБС [5][6][7][8]. Учеными из Мексики во главе с Fragoso JM, et al в 2015г выявлена ассоци-ация полиморфизмов rs1800796 и rs2069827 гена IL-6 с развитием рестенозов коронарных артерий у мекси-канских пациентов [9].…”

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The Role of Interleukin-6 Gene in Development of Idiopathic Sick Sinus Syndrome

Никулина¹,

Marilovtseva²,

Чернова³

et al. 2016

Russ J Cardiol

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Цель. Изучить ассоциацию полиморфизма rs1800795 гена IL-6 с развитием идиопатического синдрома слабости синусового узла (СССУ). Материал и методы. Проведено обследование 109 больных с идиопатиче-ским СССУ и 59 их здоровых родственников I, II, III степени родства, а также 173 пациента контрольной группы. Пациенты основной группы разделены на подгруппы соответственно полу и клиническому варианту течения заболе-вания. Всем пациентам проведено стандартное клинико-инструментальное кардиологическое обследование и молекулярно-генетическое исследование ДНК. Статистическую обработку данных проводили с использованием пакета программ "Statistica 7.0". Результаты. Установлено статистически значимое преобладание гомозигот-ного генотипа по редкому аллелю исследуемого гена в группе контроля (18,5%±3,0) по сравнению с пациентами с идиопатическим СССУ (8,5%±3,1), p=0,039, а также по сравнению с подгруппой мужчин с СССУ (5,2%±8 среди мужчин с СССУ против 30,8%±9,1 в группе контроля, р=0,03). Кроме того, установлено статистически значимое преобладание распространенного гено-типа гена IL-6 среди мужчин с компенсированным вариантом СССУ (69,2%±12,8) по сравнению с контрольной группой (23,1%±8,3, р=0,005). Заключение. Вероятно, гомозиготный генотип GG гена IL-6 играет протек-тивную роль в отношении развития идиопатического СССУ.

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IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease

Cited by 25 publications

References 25 publications

Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population

Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population

Statistical analysis of the relationship between IL-10 gene promoter polymorphisms and the development of coronary artery disease

The Role of Interleukin-6 Gene in Development of Idiopathic Sick Sinus Syndrome

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