IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation

Nanomicelle‐Assisted Targeted Ocular Delivery with Enhanced Antiinflammatory Efficacy In Vivo

“…In addition to PGE 2 , inflammation mediators can induce the release of other inflammatory cytokines such as IL‐6. Several previous studies demonstrated that IL‐6 plays an important role in ocular inflammation 31, 32, 33, 34. In this study, we found that production of IL‐6 increased 4.6 and 6.3 times in tears and aqueous humor, respectively, after ocular inflammation was induced.…”

Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages

“…Our work also demonstrates that aloe-emodin markedly suppresses the LPS-stimulated transcription and production of IL-1β and IL-6. IL-1β is an early major pro-inflammatory cytokine mediating the inflammatory response at both the local and systemic levels (Dinarello, 2000), and IL-6 plays an important role in a variety of inflammatory conditions, especially in acute-phase responses (Heinrich et al, 1990;Kaplanski et al, 2003). Collectively our data indicate that the anti-inflammatory effect of aloe-emodin is due, at least in part, to its inhibitory effects on the expression of pro-inflammatory mediators.…”

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

“…IL-6 is a strong activator of acute phase response contributing both systemic and local inflammatory response. It activates vascular endothelial cells leading to a release of chemokines e.g., IL-8, and monocyte chemoattractant protein-1, which facilitates leukocyte recruitment to inflammatory sites (Kaplanski et al, 2003). Elevated serum IL-6 in cancer patients or in tumor biopsy indicated that this cytokine plays role in cancer development (Chung et al, 2003;Kai et al, 2005).…”