IL-6/IL-10 mRNA expression ratio in tumor tissues predicts prognosis in gastric cancer patients without distant metastasis

Abstract

There was growing evidence that inflammatory responses played significant roles in malignancies. However, the impact of pro-inflammatory-to-anti-inflammatory factor ratio in tumor tissues has not been investigated in gastric cancer (GC) yet. We collected patient data from The Cancer Genome Atlas (TCGA) database. A total of 270 stomach adenocarcinoma (STAD) patients without distant metastasis were included in the study. After screening 12 candidate pro-inflammatory-to-anti-inflammatory pairs, only the IL-6/IL-10 mRNA expression ratio in tumor tissues had a significant effect on overall survival (OS) of STAD patients (P = 0.014). X-tile analysis showed that the greatest survival differences were obtained when the cutoff value of IL-6/IL-10 mRNA expression ratio was set at 1.3 and 5.5. With the low-ratio group (IL-6/IL-10 mRNA expression ratio: < 1.3) as reference, OS time for both the medium-ratio group (IL-6/IL-10 mRNA expression ratio: 1.3–5.5) and the high-ratio group (IL-6/IL-10 mRNA expression ratio: > 5.5) was significantly shorter (P < 0.05). Multivariate Cox regression analyses indicated that IL-6/IL-10 mRNA expression ratio was an independent prognostic factor for OS and disease-specific survival (DSS). These findings provided a novel and powerful tool for a more rational management of GC patients.

Nutraceutical blends predict enhanced health via microbiota reshaping improving cytokines and life quality: a Brazilian double-blind randomized trial

“…Both supplement groups exhibited notable systemic anti-inflammatory effects following a 180-day supplementation period, characterized by a reduction in chemokines closely linked to metabolic and intestinal disorders. Specifically, levels of RANTES 40 , CXCL9/MIG 78 , IL-6, and the IL-6/IL-10 ratio, recognized markers associated with inflammatory diseases such as gastric cancer 79 , witnessed a decrease in both groups. Concurrently, there was an elevation in IL-4 in both supplement groups, renowned for its anti-inflammatory properties 80 .…”

The Regular Consumption of a Food Supplement Containing Miraculin Can Contribute to Reducing Biomarkers of Inflammation and Cachexia in Malnourished Patients with Cancer and Taste Disorders: The CLINMIR Pilot Study

“…For example, it has been reported that the ratio of IL-6 to IL-10 is strongly correlated with injury severity and the intensity of the anti-inflammatory response after trauma (47). In addition, an imbalance in the systemic inflammatory response, marked by an increased IL-6/IL-10 ratio, is one of the possible factors contributing to the severity of primary open-angle glaucoma (48), gastric cancer (49) or COVID-19 patients (50). Understanding the interplay between IL-6 and IL-10, which reflects the balance between proinflammatory and anti-inflammatory cytokines, is critical for identifying patients in a hyperinflammatory state and will allow rational determination of the best treatment options for each patient (50).…”

Analysis of the <i>IL-10</i> mRNA level in the peripheral blood of patients with cancer and benign prostatic hyperplasia

“…Ранее было показано, что низкая экспрессия ИЛ-10 в опухолевых клетках увеличивает риск неблагоприятного прогноза при раке молочной железы. Cоотносительный уровень мРНК ИЛ-6 / ИЛ-10 намного выше у больных раком желудка с плохим прогнозом, а средний уровень ИЛ-10 в сыворотке крови был статистически значимо ниже у пациентов с колоректальным раком, чем у здоровых лиц, что соответствует полученным нами результатам по экспрессии мРНК ИЛ-10 у больных РПЖ [22][23][24]. Кроме того, сообщается о том, что мыши с дефицитом ИЛ-10 более 3 , n = 34; 3 -group with a PV of more than 50 cm 3 , n = 24; 4 -control group, n = 30; *differences are statistically significant compared with the control group (p <0,01); **differences are statistically significant between the group with a pancreatic volume of up to 25 cm 3 and the group with a pancreatic volume of more than 25 to 50 cm 3 (p <0.05); ***differences are statistically significant between the group with a pancreatic volume of up to 25 cm 3 and the group with a pancreatic volume of more than 50 cm 3…”