IL-6, IL-8, and IL-10 Are Associated with Hyperferritinemia in Rapidly Progressive Interstitial Lung Disease with Polymyositis/Dermatomyositis

Kawasumi, Hidenaga; Gono, Takahisa; Kawaguchi, Yasushi; Kaneko, Hirotaka; Katsumata, Yasuhiro; Hanaoka, Masanori; Kataoka, Satoshi; Yamanaka, Hisashi

doi:10.1155/2014/815245

Cited by 80 publications

(69 citation statements)

References 19 publications

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“…These patients have a poor prognosis compared with patient without anti-MDA5 antibody with early death 10. Interestingly, high serum levels of ferritin, such as in our patient, have been reported to be associated with RPILD and a poor prognosis 11. Based on the clinical presentation of our patient and his remarkable response to immunosuppression, we do not feel our patient has RPILD but seems to have a chronic form of ILD.…”

Section: Discussionmentioning

confidence: 47%

Clinically amyopathic dermatomyositis associated with anti-MDA5 antibody

Parperis¹,

Kiyani

2018

BMJ Case Reports

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Clinically amyopathic dermatomyositis (CADM) is a rare entity that presents with cutaneous manifestations of classic dermatomyositis but without muscle weakness or abnormal muscle enzymes. It is more common in young white and Asian females. A subset of patients with CADM has a specific antibody known as anti-MDA5. These patients have a more aggressive course with distinct cutaneous features, pulmonary involvement and early death. Here, we present the case of a 64-year-old Caucasian male with no significant medical history who was admitted with marked weight loss and a painful rash for 6 months. Patient had no muscle weakness and his rash was characteristic of classic dermatomyositis. Skin biopsy was suggestive of dermatomyositis but muscle enzymes were normal. His serum was positive for anti-MDA5 antibody. Extensive workup failed to detect any malignancy but he did show non-specific interstitial pneumonia. He was treated with prednisone and mycophenolate with good clinical response.

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Section: Discussionmentioning

confidence: 47%

Clinically amyopathic dermatomyositis associated with anti-MDA5 antibody

Parperis¹,

Kiyani

2018

BMJ Case Reports

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“…These regulatory cytokines include IL-1, IL-6, IL-18 and TNF-alpha, all of which are also involved in the pathogenesis of GPA [22,23]. Therefore, increased ferritin levels could be explained by extreme cytokine production during acute stage of disease.…”

Section: Discussionmentioning

confidence: 99%

Serum ferritin as an activity marker for granulamotosis with polyangiitis

et al. 2017

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Background: Serum ferritin correlates well with the activities of systemic lupus erythematosus (SLE) and dermatomyositis, but it has not been previously studied in patients with vasculitis. Methods: Medical records of granulomatosis with polyangiitis (GPA, Wegener's granulomatosis) patients with at least six months of regular follow-up were evaluated. The activity of GPA was assessed with Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG). Serum ferritin and other acute phase markers were measured at initial presentation. Results: Serum ferritin levels were found to be the highest in GPA patients with alveolar hemorrhage, median (IQR) 1041 (1281) lg/L. Patients with renal disease also had high levels of ferritin and it was correlated with concurrent glomerular filtration rate (r ¼ À0.65, p < .001). Serum ferritin is also correlated well with the BVAS/WG scores (r ¼ 0.79, p < .001). Conclusions: Measurement of serum ferritin might help in assessing disease activity of GPA.

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“…Among the different serum biomarkers investigated, high levels of tumor necrosis factor-α are associated with the development of ILD whereas those of IL-8 may predict a worse prognosis in the presence of ILD associated with DM-PM [195] . Furthermore, high levels of serum ferritin, IL-6, IL-8 and IL-10 characterize a more severe ILD phenotype in DM-PM [196] . Secondary lung complications include the development of pulmonary hypertension in the setting of already established ILD and complications related to the development of muscle weakness such as aspiration pneumonia and hypercapnic respiratory failure.…”

Section: Dermatomyositis-polymyositismentioning

confidence: 99%

Investigation of Lung Involvement in Connective Tissue Disorders

Papiris¹,

Manali²,

Kolilekas³

et al. 2015

Respiration

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Lung involvement in connective tissue disorders (CTDs) may present as pleomorphic since any lung compartment may be involved such as airways, exocrine secretory and alveolar epithelia, interstitial lung structure, pulmonary vasculature and pleura as well as, in specific disorders, several tissues of the thoracoabdominal ventilator pump. Any combination of the above anatomic structures may be involved concomitantly although some specific combinations may include a determinant of rheumatic disorders. The diagnosis of a specific CTD requires the fulfilment of clearly defined clinical and laboratory criteria including in most cases positivity for autoantibodies, mostly specific serologic combinations. In this setting, serologic investigation targets mainly, although not exclusively, the detection of antinuclear antibodies. A specific serologic positivity or a combination of autoantibodies constitutes not only a diagnostic criterion for a specific CTD, but may also characterize the pattern of respiratory manifestation in a determinant rheumatic disorder. Therefore, the investigation of lung involvement in CTDs requires adequate skills in the ambit of a multidisciplinary approach and an extended spectrum of diagnostic tools and modalities able to detect both early clinical clues and serologic conversion as well as any pathophysiologic alteration that regards the complexity of respiratory functional status. Although many patients with CTDs suffer from a ‘vicious' combination of lung involvement, lung drug toxicity and infections related to the above two as well as to the ‘mater' disease, for space reasons this review will focus on the established lung manifestations that regard the 7 major CTDs.

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IL-6, IL-8, and IL-10 Are Associated with Hyperferritinemia in Rapidly Progressive Interstitial Lung Disease with Polymyositis/Dermatomyositis

Cited by 80 publications

References 19 publications

Clinically amyopathic dermatomyositis associated with anti-MDA5 antibody

Clinically amyopathic dermatomyositis associated with anti-MDA5 antibody

Serum ferritin as an activity marker for granulamotosis with polyangiitis

Investigation of Lung Involvement in Connective Tissue Disorders

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