2018
DOI: 10.1007/s10787-018-0458-0
|View full text |Cite
|
Sign up to set email alerts
|

IL-6 signalling pathways and the development of type 2 diabetes

Abstract: Interleukin 6 (IL-6), a multifunctional cytokine, has been implicated in the pathophysiology of type 2 diabetes (T2D). The elevated circulating level of IL-6 is an independent predictor of T2D and is considered to be involved in the development of inflammation, insulin resistance and β-cell dysfunction. On the other hand, an increasing number of evidence suggests that IL-6 has an anti-inflammatory role and improves glucose metabolism. The complex signal transduction mechanism of IL-6 may help explain the pleio… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

7
174
0
5

Year Published

2018
2018
2024
2024

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 222 publications
(186 citation statements)
references
References 80 publications
7
174
0
5
Order By: Relevance
“…An opposite effect is carried out on α-cells; IL-6 prevents α-cells apoptosis and induces the secretion of glucagon-like peptide-1. This could be considered an adaptive mechanism to compensate for β-cell failure (Ellingsgaard et al, 2008(Ellingsgaard et al, , 2011Akbari and Hassan-Zadeh, 2018). Such findings support the tissue-specific effect of IL-6 on glucose homeostasis, which depends on several factors, such as concentrations, targets, and signaling pathways activated.…”
Section: Molecular Pathways Linking Obesity-induced Inflammation and Irsupporting
confidence: 68%
“…An opposite effect is carried out on α-cells; IL-6 prevents α-cells apoptosis and induces the secretion of glucagon-like peptide-1. This could be considered an adaptive mechanism to compensate for β-cell failure (Ellingsgaard et al, 2008(Ellingsgaard et al, , 2011Akbari and Hassan-Zadeh, 2018). Such findings support the tissue-specific effect of IL-6 on glucose homeostasis, which depends on several factors, such as concentrations, targets, and signaling pathways activated.…”
Section: Molecular Pathways Linking Obesity-induced Inflammation and Irsupporting
confidence: 68%
“…Inflammation plays an important role in DM progression. High levels of proinflammatory IL-6 were observed in persons with prediabetes and patients, diagnosed with DM [24][25][26][27]. In our study we obtained similar results: in patients with DM significantly higher levels of IL-6 were observed compared to those without DM.…”
Section: Introductionsupporting
confidence: 86%
“…IL-6 is also released from skeletal muscle and may mediate cross-talk between WAT and skeletal muscle 95 . The metabolic effects of IL-6 is probably dependent on whether the elevation of IL-6 is acute or chronic, as reviewed 107 . Acute IL-6 rise as in exercising muscle seem to reduce inflammation and promote insulin sensitivity whereas a chronic rise is associated with inflammation and reduced insulin sensitivity.…”
Section: Adipokinesmentioning
confidence: 99%