Il-7 Enhances the Anti-Tumor Response in Non-Small Cell Lung Cancer

Yang, Seung Ho; Kim, Young Whan; Yoo, Chul‐Gyu; Lee, San Min; Lee, Choon–Taek; Han, Sung Koo; Shim, Young‐Soo; Lim, Jae-Jun; Hillinger, Sven; Zhu, Li; Dubinett, Steven M.; Sharma, Sherven

doi:10.1378/chest.132.4_meetingabstracts.458b

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“…IL-7 is a proinflammatory cytokine involved in growth of pre–B lymphocytes and pre–T lymphocytes, is elevated in patients with T cell depletion, activates macrophages, up-regulates expression of the proangiogenic IL-8, and aids in T-lymphocyte survival. IL-7R expression has been shown in neoplastic lung cell lines (31), and IL-7 systemic therapy has been shown to increase antitumor T-cell lytic activity in mice bearing NSCLC tumors (32). One potential mechanistic link among smoking, IL-7, and lung cancer may be the up-regulation of IL-8 expression by IL-7 (33).…”

Section: Discussionmentioning

confidence: 99%

Cytokine and Cytokine Receptor Single-Nucleotide Polymorphisms Predict Risk for Non–Small Cell Lung Cancer among Women

Dyke¹,

Coté

Wenzlaff³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Studies on the relationships between inflammatory pathway genes and lung cancer risk have not included African-Americans and have only included a handful of genes. In a population-based case-control study on 198 African-American and 744 Caucasian women, we examined the association between 70 cytokine and cytokine receptor single-nucleotide polymorphisms (SNPs) and risk of non–small cell lung cancer (NSCLC). Unconditional logistic regression was used to estimate odds ratios and 95% confidence intervals in a dominant model adjusting for major risk factors for lung cancer. Separate analyses were conducted by race and by smoking history and history of chronic obstructive pulmonary disease among Caucasians. Random forest analysis was conducted by race. On logistic regression analysis, IL6 (interleukin 6), IL7R, IL15, TNF (tumor necrosis factor), and IL10 SNP were associated with risk of non–small cell lung cancer among African-Americans; IL7R and IL10 SNPs were also associated with risk of lung cancer among Caucasians. Although random forest analysis showed IL7R and IL10 SNPs as being associated with risk for lung cancer among African-Americans, it also identified TNFRSF10A SNP as an important predictor. On random forest analysis, an IL1A SNP was identified as an important predictor of lung cancer among Caucasian women. Inflammatory SNPs differentially predicted risk for NSCLC according to race, as well as based on smoking history and history of chronic obstructive pulmonary disease among Caucasian women. Pathway analysis results are presented. Inflammatory pathway genotypes may serve to define a high risk group; further exploration of these genes in minority populations is warranted.

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Section: Discussionmentioning

confidence: 99%