IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells

Shimizu, Masahiro; Tanaka, Nobuyuki

doi:10.1038/s41388-018-0533-4

Cited by 75 publications

(46 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This positive feedback loop offers a constant supply of HBP-coupled HIF-1α signaling that is required for mammosphere formation and maintenance of the CSC (CD44 H CD24 L ) population [119]. A similar positive correlation of CSC properties and markers is observed with elevated GFAT1 levels [89, 119–121]. Additionally, liver cancer stem cell populations, as measured by CD133 cell-surface marker, are reduced following Azaserine (a glutamine analog and GFAT1 inhibitor) treatment as well as glucose deprivation, and this effect can be rescued with GlcNAc in glucose-deprived cells [120].…”

Section: Hbp and Cancer Stem Cellsmentioning

confidence: 99%

“…Additionally, liver cancer stem cell populations, as measured by CD133 cell-surface marker, are reduced following Azaserine (a glutamine analog and GFAT1 inhibitor) treatment as well as glucose deprivation, and this effect can be rescued with GlcNAc in glucose-deprived cells [120]. In lung and colon cancer cells, IL-8 is able to enhance CSC-associated sphere formation in vitro and tumor initiation in vivo by upregulating GFAT expression, glucose uptake, Sox2 expression, and total O-GlcNAcylation in a GLUT-3-dependent manner [121]. A recent report identified O-GlcNAc modification of eIF4E in hepatocellular carcinoma on Thr168 and Thr177.…”

Section: Hbp and Cancer Stem Cellsmentioning

confidence: 99%

See 1 more Smart Citation

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

2019

View full text Add to dashboard Cite

Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway (HBP). The HBP culminates in the production of an amino sugar uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) that, along with other charged nucleotide sugars, serves as the basis for biosynthesis of glycoproteins and other glycoconjugates. These nutrient-driven post-translational modifications are highly altered in cancer and regulate protein functions in various cancer-associated processes. In this review, we discuss recent progress in understanding the mechanistic relationship between the HBP and cancer.

show abstract

Section: Hbp and Cancer Stem Cellsmentioning

confidence: 99%

Section: Hbp and Cancer Stem Cellsmentioning

confidence: 99%

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

2019

View full text Add to dashboard Cite

show abstract

“…Integrin αvβ6 plays a vital role in the proliferation, apoptosis, metastasis and matrix metalloproteinase secretion of CRC, and human CRC cells with silenced αvβ6 show a reduction in IL-8-induced migration [98]. Besides, recent studies reported that IL-8 was required for the expression of cancer stem cell (CSC) properties through protein O-GlcNAcylation promotion, glucose uptake stimulation and glucose transporter 3 (GLUT3) and glucosamine fructose-6-phosphate aminotransferase (GFAT) upregulation [99].…”

Section: Il-8mentioning

confidence: 99%

The Role of Interleukins in Colorectal Cancer

Huang

Zhao

et al. 2020

Int. J. Biol. Sci.

View full text Add to dashboard Cite

Despite great progress has been made in treatment strategies, colorectal cancer (CRC) remains the predominant life-threatening malignancy with the feature of high morbidity and mortality. It has been widely acknowledged that the dysfunction of immune system, including aberrantly expressed cytokines, is strongly correlated with the pathogenesis and progression of colorectal cancer. As one of the most well-known cytokines that were discovered centuries ago, interleukins are now uncovering new insights into colorectal cancer therapy. Herein, we divide currently known interleukins into 6 families, including IL-1 family, IL-2 family, IL-6 family, IL-8 family, IL-10 family and IL-17 family. In addition, we comprehensively reviewed the oncogenic or antitumour function of each interleukin involved in CRC pathogenesis and progression by elucidating the underlying mechanisms. Furthermore, by providing interleukins-associated clinical trials, we have further driven the profound prospect of interleukins in the treatment of colorectal cancer.

show abstract

“…This pathway has been described as a sensor of nutrient availability that stimulates cancer cell growth and proliferation when the abundance of glucose and other nutrients in the microenvironment allow it [ 32 ]. The hexosamine biosynthetic pathway is required for Kras-induced transformation [ 33 ], and increased hexosamine biosynthetic pathway has been associated with epithelial to mesenchymal transition [ 34 ], cancer stem cell phenotype [ 35 ], and regulates the function of receptor tyrosine kinases [ 36 ] and oncogenes [ 33 ].…”

Section: Glucose Metabolism In Cancermentioning

confidence: 99%

Heterogeneity of Glucose Transport in Lung Cancer

Rivera

Scafoglio

2020

Biomolecules

View full text Add to dashboard Cite

Increased glucose uptake is a known hallmark of cancer. Cancer cells need glucose for energy production via glycolysis and the tricarboxylic acid cycle, and also to fuel the pentose phosphate pathway, the serine biosynthetic pathway, lipogenesis, and the hexosamine pathway. For this reason, glucose transport inhibition is an emerging new treatment for different malignancies, including lung cancer. However, studies both in animal models and in humans have shown high levels of heterogeneity in the utilization of glucose and other metabolites in cancer, unveiling a complexity that is difficult to target therapeutically. Here, we present an overview of different levels of heterogeneity in glucose uptake and utilization in lung cancer, with diagnostic and therapeutic implications.

show abstract

IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells

Cited by 75 publications

References 54 publications

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

The Role of Interleukins in Colorectal Cancer

Heterogeneity of Glucose Transport in Lung Cancer

Contact Info

Product

Resources

About