2023
DOI: 10.1038/s41467-023-39815-5
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IL-9 aggravates SARS-CoV-2 infection and exacerbates associated airway inflammation

Srikanth Sadhu,
Rajdeep Dalal,
Jyotsna Dandotiya
et al.

Abstract: SARS-CoV-2 infection is known for causing broncho-alveolar inflammation. Interleukin 9 (IL-9) induces airway inflammation and bronchial hyper responsiveness in respiratory viral illnesses and allergic inflammation, however, IL-9 has not been assigned a pathologic role in COVID-19. Here we show, in a K18-hACE2 transgenic (ACE2.Tg) mouse model, that IL-9 contributes to and exacerbates viral spread and airway inflammation caused by SARS-CoV-2 infection. ACE2.Tg mice with CD4+ T cell-specific deficiency of the tra… Show more

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Cited by 16 publications
(9 citation statements)
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“…The z score was also higher for IL-10, with IL-10 elevated in severe COVID-19, but also able to suppress hyper-cyotokinemia [1820]. Elevated IL-4, IL-9 and IL-13 have been associated with more severe disease [21, 22, 91], although IL-9, IL-13 (and IL-5) are produced by type 2 innate lymphoid cells (ILC2 cells) [92] (see below), and increased IL-4 and IL-13 signatures may (in this context) reflect a relatively more balanced Th1/Th2 response [25, 26]. Elevated OSM and IL-6 are also associated with more severe disease [17, 93].…”
Section: Resultsmentioning
confidence: 99%
“…The z score was also higher for IL-10, with IL-10 elevated in severe COVID-19, but also able to suppress hyper-cyotokinemia [1820]. Elevated IL-4, IL-9 and IL-13 have been associated with more severe disease [21, 22, 91], although IL-9, IL-13 (and IL-5) are produced by type 2 innate lymphoid cells (ILC2 cells) [92] (see below), and increased IL-4 and IL-13 signatures may (in this context) reflect a relatively more balanced Th1/Th2 response [25, 26]. Elevated OSM and IL-6 are also associated with more severe disease [17, 93].…”
Section: Resultsmentioning
confidence: 99%
“…Several studies revealed that uterine, exposure of SARS‐CoV‐2 induce immune response 35 and recently, Sadhu et al showed that elevated levels of IL‐9 increased the airway inflammation 36 . Collectively, elevated levels of these cytokines suggested an immune active state in cord blood (baby).…”
Section: Resultsmentioning
confidence: 99%
“…Recently, Sadhu et al showed that elevated levels of IL-9 increase the airway inflammation. 36 Also, several studies showed that IL-1β has important role in induction of immune response in COVID-19 infection. 35 TNF-α is considered as a potent regulator of lipid and NAD + metabolism.…”
Section: Discussionmentioning
confidence: 99%
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