IL-9 antibody injection suppresses the inflammation in colitis mice

Yuan, Ang; Yang, Hang; Qi, Haili; Cui, Jing; Wei, Hua; Li, Can; Pang, Zhigang; Zheng, Wei; Cui, Guanglin

doi:10.1016/j.bbrc.2015.11.057

Cited by 31 publications

(25 citation statements)

References 31 publications

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“…78 The involvement of Th9 cells in the pathobiology of IBD is increasingly appreciated as blockade of IL-9 has been shown to attenuate disease severity in experimental models of IBD. 79,80 In agreement with a loss of regulatory function and a gain of pro-inflammatory function for αEβ7 + T lymphocytes in the disease pathogenesis of UC, these cells have lower expression of T regassociated genes, including FOXP3, IL-10, CTLA-4, and ICOS, compared with the αEβ7 − T-lymphocyte subset. 73 Furthermore, in CD, αEβ7 is highly expressed on the expanded subset of CD4 + T lymphocytes expressing the activating receptor NKG2D, which exhibits pro-inflammatory and cytotoxic properties.…”

Section: αEβ7-expressing T Lymphocytesmentioning

confidence: 70%

“…αEβ7 integrin expression is also highly expressed on CD8 + and Th9 lymphocytes . The involvement of Th9 cells in the pathobiology of IBD is increasingly appreciated as blockade of IL‐9 has been shown to attenuate disease severity in experimental models of IBD . In agreement with a loss of regulatory function and a gain of pro‐inflammatory function for αEβ7 + T lymphocytes in the disease pathogenesis of UC, these cells have lower expression of T reg ‐associated genes, including FOXP3, IL‐10, CTLA‐4, and ICOS, compared with the αEβ7 − T‐lymphocyte subset .…”

Section: Immune Cell Functions In the Gut And Ibdmentioning

confidence: 91%

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The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti‐integrin therapies

Dotan

Allez

Danese

et al. 2019

Medicinal Research Reviews

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Inflammatory bowel disease (IBD) is characterized by uncontrolled inflammation in the gastrointestinal tract. The underlying pathobiology of IBD includes an increase in infiltrating gut‐homing lymphocytes. Although lymphocyte homing is typically a tightly regulated and stepwise process involving multiple integrins and adhesion molecules expressed on endothelial cells, the distinct roles of integrin‐expressing immune cells is not fully understood in the pathology of IBD. In this review, we detail the involvement of integrins expressed on specific lymphocyte subsets in the pathogenesis of IBD and discuss the current status of approved and investigational integrin‐targeted therapies.

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Section: αEβ7-expressing T Lymphocytesmentioning

confidence: 70%

Section: Immune Cell Functions In the Gut And Ibdmentioning

confidence: 91%

The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti‐integrin therapies

Dotan

Allez

Danese

et al. 2019

Medicinal Research Reviews

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“…37 This was later confirmed by the use of IL-9 deficient mice in the TNBS colitis model 133 and through administration of anti-IL-9 antibody in DSS colitis. 134 Consistently, IL-9 expression in T cells and IL-9R expression in IECs from UC patients was found to be significantly elevated. 135 Recently, IL-9 was also detected in the serum of IBD patients.…”

Section: Th9 Cellsmentioning

confidence: 71%

“…In an investigation taking advantage of the oxazolone colitis model in PU.1‐deficient mice, disease protection conferred by the absence of Th9 cells was demonstrated and mechanistically linked to protective functions of IL‐9 for epithelial barrier integrity . This was later confirmed by the use of IL‐9 deficient mice in the TNBS colitis model and through administration of anti‐IL‐9 antibody in DSS colitis . Consistently, IL‐9 expression in T cells and IL‐9R expression in IECs from UC patients was found to be significantly elevated .…”

Section: T Cell Subsets In Allergic and Chronic Inflammatory Bowel DImentioning

confidence: 85%

Pathogenic T cell subsets in allergic and chronic inflammatory bowel disorders

Zundler

Neurath

2017

Immunological Reviews

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Homeostasis in the gastrointestinal tract relies on a sensitive equilibrium between permissive and protective functions. This is closely reflected in the regulation of the intestinal immune system and especially T cells in the gut. This balance, however, is susceptible to disturbances as demonstrated by pathological conditions like food allergy, celiac disease, or inflammatory bowel disease. In these allergic and chronic inflammatory bowel disorders, luminal antigens get access to the lamina propria where they trigger a dysregulated immune response with crucial involvement of different T cell subsets. We will begin this review with some comprehensive remarks on current concepts on the pathogenesis of these diseases before taking a closer look at the life cycle of intestinal T cells consisting of priming, homing, differentiation and proliferation and apoptosis respectively. Subsequently we will discuss the specific implication of distinct T cell subsets in allergic and chronic inflammatory conditions of the gastrointestinal tract in detail and comment on current and future approaches to targeted therapy in this context.

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“…O tratamento com anti-IL17A (secukinumab) resultou em rápida redução dos sintomas em pacientes portadores de psoríase, artrite reumatóide e espondilite anquilosante (24) . O mesmo foi evidenciado em estudos com modelos experimentais que utilizaram inibidores de IL9, os quais apresentaram eficácia para psoríase, artrite reumatóide e para controle das doenças inflamatórias intestinais (25) .…”

Section: Polarização De Linfócitos: Relevância Fisiopatológica De Th9unclassified

Polarização de linfócitos: Relevância fisiopatológica de Th9 e Th17

et al. 2018

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A polarização de células TCD4+ é um dos mecanismos mais importantes da resposta imunológica. Cada um dos subtipos ou padrões de células são originados a partir da polarização decorrente da interação de células TCD4+ naives com antígenos apresentados por células apresentadoras de antígenos. A expressão de determinados fatores de transcrição e a produção de interleucinas específicas constituem a identidade de cada um deles. Além de Th1 e Th2 já comumente descritos, o papel das polarizações Th17 e Th9 se mostram cada vez mais presentes na fisiopatologia de diversas doenças e constituem um caminho promissor para traçar possíveis estratégias terapêuticas.

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IL-9 antibody injection suppresses the inflammation in colitis mice

Cited by 31 publications

References 31 publications

The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti‐integrin therapies

The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti‐integrin therapies

Pathogenic T cell subsets in allergic and chronic inflammatory bowel disorders

Polarização de linfócitos: Relevância fisiopatológica de Th9 e Th17

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