IL10A genotypic association with decreased IL-10 circulating levels in malaria infected individuals from endemic area of the Brazilian Amazon

Pereira, Virgínia Araújo; Sánchez‐Arcila, Juan Camilo; Têva, Antônio; Perce-da-Silva, Daiana de Souza; Vasconcelos, Mariana Pinheiro Alves; Lima, Cleoni Alves Mendes de; Aprígio, Cesarino Junior Lima; Rodrigues-da-Silva, Rodrigo Nunes; Santos, Davi O; Banic, Dalma Maria; Bonecini-Almeida, Maria da Glória; Lima-Junior, Josué Costa; Oliveira-Ferreira, Joseli

doi:10.1186/s12936-015-0548-z

Cited by 19 publications

(21 citation statements)

References 47 publications

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“…Studies conducted in the United States with African-American and Caucasian populations found higher frequencies of 66% and 37% [76] and 48% and 25% [77], respectively. Our data showing the higher frequency of the mutant A allele are in agreement with studies in the Brazilian Amazon that found frequencies of 70.13% [21] and 73% [17] but all lacked an association with malaria caused by P. vivax or P. falciparum . Few studies have described an association between this SNP with malaria; however, its association with dermatitis was observed in India [78].…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, polymorphisms in cytokine genes can alter the production or activity of these proteins and consequently affect the inflammatory response to malaria [16–18]. As a result, these polymorphisms may be associated with susceptibility to or progression of disease [17, 19]. …”

Section: Introductionmentioning

confidence: 99%

“…In malaria, this cytokine is believed to play roles in both pathogenesis and protection [33]. Some studies have evaluated potential associations between IFNG gene polymorphisms (including SNP +874A>T) and malaria and found no association with susceptibility to vivax malaria [17] or severity of P. falciparum infections [34]. A recent study also found no association between the presence of SNP +874A>T and the antibody response against P. vivax blood-stage proteins [35].…”

Section: Introductionmentioning

confidence: 99%

“…IL-10 cytokine has a negative immunoregulatory effect [36, 37] on IL-1, IL-6, IL-8, IL-12, IFN- γ , and TNF- α [17, 27] that is essential for maintaining homeostasis and limiting tissue damage by infectious agents [34]. The production of the IgG, IgA, and IgM isotypes induced by IL-4 is synergistic with IL-10 [38].…”

Section: Introductionmentioning

confidence: 99%

“…The proportion of C alleles of SNPs -819 and -592 was lower in individuals infected with P. vivax than in healthy individuals. Furthermore, individuals carrying the genotypes -819CC and -592CC had lower levels of circulating IL-10 [17]. By contrast, another study conducted in the Brazilian Amazon found no association between the presence of these SNPs and susceptibility to P. vivax [21].…”

Section: Introductionmentioning

confidence: 99%

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Frequency ofTNFA,INFG, andIL10Gene Polymorphisms and Their Association with MalariaVivaxand Genomic Ancestry

Furini

Cassiano

Capobianco

et al. 2016

Mediators of Inflammation

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Polymorphisms in cytokine genes can alter the production of these proteins and consequently affect the immune response. The trihybrid heterogeneity of the Brazilian population is characterized as a condition for the use of ancestry informative markers. The objective of this study was to evaluate the frequency of -1031T>C, -308G>A and -238G>A TNFA, +874 A>T IFNG and -819C>T, and -592C>A IL10 gene polymorphisms and their association with malaria vivax and genomic ancestry. Samples from 90 vivax malaria-infected individuals and 51 noninfected individuals from northern Brazil were evaluated. Genotyping was carried out by using ASO-PCR or PCR/RFLP. The genomic ancestry of the individuals was classified using 48 insertion/deletion polymorphism biallelic markers. There were no differences in the proportions of African, European, and Native American ancestry between men and women. No significant association was observed for the allele and genotype frequencies of the 6 SNPs between malaria-infected and noninfected individuals. However, there was a trend toward decreasing the frequency of individuals carrying the TNF-308A allele with the increasing proportion of European ancestry. No ethnic-specific SNPs were identified, and there was no allelic or genotype association with susceptibility or resistance to vivax malaria. Understanding the genomic mechanisms by which ancestry influences this association is critical and requires further study.

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