IL1B genetic variation and plasma C-reactive protein level among young adults: The CARDIA study

Enquobahrie, Daniel A.; Rice, Kenneth; Williams, O. Dale; Williams, Michelle A.; Gross, Myron D.; Lewis, Cora E.; Schwartz, Stephen M.; Siscovick, David S.

doi:10.1016/j.atherosclerosis.2008.05.018

Cited by 16 publications

(7 citation statements)

References 31 publications

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“…Similarly, rs3917356 (IL1B), which was found to be significantly associated with IgAN susceptibility and foot process effacement in our study, has been reported to be a C-reactive protein (CRP) modulator [35], which supports the possibility that rs3917356 plays a crucial role in inflammatory events, including those associated with IgAN.…”

Section: Discussionsupporting

confidence: 85%

Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy

et al. 2009

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We have carried out a study with the aim of investigating the association between single nucleotide polymorphisms (SNPs) of the IL-1 gene cluster and childhood IgA nephropathy (IgAN). SNPs of the IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (RN) genes (IL1A, IL1B, and IL1RN, respectively) were analyzed in 182 patients with childhood IgAN and in 500 healthy controls. The IgAN patients were also dichotomized and compared with respect to proteinuria (<4 mg and >or=4 mg/m(2) per hour, respectively), the presence or absence of podocyte foot process effacement, and the presence of pathologically early and advanced disease markers, such as interstitial fibrosis, tubular atrophy, or global sclerosis. Significant differences in SNP frequencies were observed for the IL1B and IL1RN genes (rs1143627, rs3917356, and rs1143633 in the IL1B gene, and rs928940, rs439154, and rs315951 in the IL1RN gene). Moreover, rs1143627, rs3917356, and rs1143633 of IL1B were found to be significantly associated with the presence of podocyte foot process effacement. Our results suggest that the IL1B and IL1RN genes are associated with increased susceptibility to IgAN in children. They also suggest that the development of proteinuria in IgAN is related to IL1A and that podocyte foot process effacement is associated with IL1B.

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Section: Discussionsupporting

confidence: 85%

Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy

et al. 2009

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“…Cytokine plasma levels of IL-1β were also elevated in the long napping group in the bivariate analysis and differed significantly by IL1B rs1143642 genotype after adjusting for GEA, self-reported race/ethnicity, and clinical variables. IL1B rs1143642, which is located in an intronic region, is also associated with increased C-reactive protein levels over time in obese populations [49]. Our findings suggest IL-1β plasma levels and the IL1B gene may be involved in regulating daytime napping in adults living with HIV/AIDS.…”

Section: Discussionmentioning

confidence: 79%

Cytokine polymorphisms are associated with daytime napping in adults living with HIV

et al. 2017

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Objective/Background Daytime napping longer than one hour has been associated with an increased risk for all-cause mortality. Associations between cytokine polymorphisms and daytime napping in chronic illnesses such as HIV, however, have not been well described. The purpose of this study was to examine cytokine polymorphisms associated with long daytime napping in adults living with HIV. Methods A cross-sectional analysis was conducted using a convenience sample of 257 adults living with HIV. Daytime napping was assessed with wrist actigraphy data collected over three days. Participants categorized as long nappers (≥ 60 min) were compared to short nappers and non-nappers (< 60 min). Single nucleotide polymorphisms (SNPs) for 15 candidate genes involved in cytokine signaling were analyzed. Genes included: interferon-gamma (IFNG), IFNG receptor 1 (IFNGR1), interleukins (IL1B, IL1R, IL1R2, IL2, IL4, IL6, IL8, IL10, IL13, IL17A), nuclear factors of kappa light polypeptide gene enhancer in B cells (NFKB1 and NFKB2), and tumor necrosis factor alpha (TNFA). Results After adjusting for relevant demographic and clinical characteristics, long daytime napping was associated with 12 SNPs from seven genes: 1) IFNG rs2069728; 2) IL1B rs1143642, rs1143627, and rs16944; 3) IL2 rs2069763; 4) IL6 rs4719714, rs1554606, and rs2069845; 5) IL17A rs3819024 and rs8193036; 6) NFKB1 rs4648110; and 7) NFKB2 rs1056890. Conclusions Cytokine genetic variations may have a role in physiological regulation of daytime napping as well as nocturnal sleep. Cytokine polymorphisms associated with long daytime napping could help identify adults with HIV who may benefit from targeted therapeutic interventions.

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“…(see Table II) are biologically relevant. For example, IL1B has been linked to obesity and CVD [125]. CCL3L1 copy number variations have been linked to immune response, but may also be linked to cardiovascular-related diseases [126].…”

Section: Section V Microarray Case Studymentioning

confidence: 99%