IL1R1 Polymorphisms are Associated with Lumbar Disc Herniation Risk in the Northwestern Chinese Han Population

Zhu, Yong; Li, Shunan; Sun, Yao; Wu, Jia‐Min; Xiong, Zichao; Jin, Tianbo; Jia, Haiyu; Yang, Xuejun

doi:10.12659/msm.913563

Cited by 7 publications

(2 citation statements)

References 35 publications

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“…A study [16] enrolled 2449 volunteers to explore the possible factors associated with MC, and the results confirmed that disc displacement and a higher disc degeneration score were associated with MC at the upper lumbar levels (L1/L2-L3/L4) (p<.01), while MC at the lowest 2 lumbar levels (L4/L5-L5/S1) were associated with the presence of Schmorl nodes, older patient age, disc degeneration or displacement, and historical lumbar injury. Research showed that cartilage and osseous endplate play an important role in biomechanics of the spine; the volume and shape of the disc is affected as the load on the spine increases, resulting in bending deformation of cartilage, the osseous endplate, and trabecular bone under the endplate [17][18][19][20]. MC may happen with the occurrence of these irreversible deformable injuries and microfracture of the cartilage, osseous endplate, and trabecular bone under the endplate [21][22][23][24][25].…”

Section: E919667-4mentioning

confidence: 99%

Analysis of the Relationship Between Modic Change and Spinopelvic Parameters in the Sagittal Plane

Lian

et al. 2020

Med Sci Monit

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Departmental sources Background: This study explored relationship between Modic change and spinopelvic parameters in the sagittal plane. Material/Methods: We divided 80 patients into 4 groups: 60 subjects diagnosed with Modic changes (MC) were enrolled in the MC groups (MC1, MC2, and MC3) with each MC type consisting of 20 subjects, and 60 healthy subjects were enrolled in the control group. Spinopelvic parameters in the sagittal plane were calculated to assess their associations with MC. Multivariate logistic regression was used to explore possible risk factors for MC. Results: PI and LL in the MC groups were significant smaller than in the control group (p<0.05). PI, SS, and PT were significantly correlated with LL with a correlation coefficient of 0.75 PI , 0.71 SS and 0.69 PT (p<0.05). Multivariate logistic regression of the significant variables showed that PI (less than 43.2°) is an independent significant risk factor for MC. ROC analysis showed that moderate diagnostic value was obtained for the significant variable, with an area under the curve (AUC) of 0.80 (p>0.05). Conclusions: We concluded that PI is risk factor for MC, and smaller PI is associated with higher incidence of MC.

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Section: E919667-4mentioning

confidence: 99%

Analysis of the Relationship Between Modic Change and Spinopelvic Parameters in the Sagittal Plane

Lian

et al. 2020

Med Sci Monit

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“…The course of the disease is lingering and does not heal for a long time. It accompanies the patients for a long time, and can gradually develop to the extent that it affects the activities of both lower limbs and even the excretion of urine and feces (11)(12). It brings great inconvenience to the study, work and life of the patients.…”

Section: Introductionmentioning

confidence: 99%

TNFAIP3 Mediated by Novel Nano Composite Adsorbent on Tumor Necrosis Factor-𝛂 in Rats with Lumbar Disc Herniation by Inhibiting 𝐍𝐅−𝛋𝐁 Pathway

Wang¹,

Ding²

2022

Cell Mol Biol (Noisy-le-grand)

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Mobile phones and computers have been widely used in the work of people. The incidence rate of lumbar disc herniation(LDH) has gradually increased and the trend toward younger age has been increasing. According to the epidemiological survey, about half of people will experience lumbar pain in their life and the resulting huge social and economic burden. It has important clinical significance for the treatment of lumbar disc herniation of TNFaIP3 mediated by a new nanocomposite adsorbent on tumor necrosis factor(TNF)-α in rats with LDH by inhibiting the NF − κB pathway. This paper mainly studies the mechanism and efficacy of TNFaIP3 mediated by a new nanocomposite adsorbent on TNF-α in rats with LDH by inhibiting the NF − κB pathway. Eight groups of human nucleus pulposus cells were randomly divided into four groups: high inhibition group, medium inhibition group, low inhibition group and no inhibition group. After interfering with human nucleus pulposus cells by inhibiting the NF − κB pathway, the cells were allowed to stand for 24 hours to extract and detect TNF-α, p-p65, P50, IKB−α and IKK−β in the NF − κB signaling pathway to explore the mechanism of inhibiting NF − κB pathway on TNF-α in rats with LDH. The experimental results showed that after 24 hours of intervention, compared with the non-inhibition group, the expression of TNF in the low inhibition group, medium inhibition group and high inhibition group decreased relatively, and with the increase of inhibition degree, the expression of TNF in each group decreased more obviously, such as the expression of TNF −αin non-inhibition group was 1.48, the expression of TNF in low inhibition group was 1.31, the expression of TNF in medium inhibition group was 0.74, and the expression of TNF in high inhibition group was 0.58. The expression of P50 was 1.86 in non-inhibition, 1.47 in low inhibition, 1.32 in medium inhibition and 1.13 in high inhibition.

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Incidence of and risk factors for lumbar disc herniation with radiculopathy in adults: a systematic review

Hincapié,

Kroismayr,

Hofstetter

et al. 2024

Eur Spine J

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Background Lumbar disc herniation (LDH) with radiculopathy is associated with greater pain, disability, healthcare use, and costs compared with nonspecific low back pain. Reliable information about its incidence and risk factors were lacking. Questions (1) What is the incidence of lumbar disc herniation (LDH) with radiculopathy in adults? (2) What are the risk factors for LDH with radiculopathy in adults? Methods Systematic review. We searched five electronic databases from 1970 to September 2023. Eligible cohort and case–control studies were identified and independently assessed for risk of bias. A qualitative best evidence synthesis of low and moderate risk of bias studies was conducted. Results We critically reviewed 87 studies and synthesised data from 59 (68%) studies; 12 were of low and 47 of moderate risk of bias. The lower and upper bound limits of the 95% CIs of annual incidence estimates ranged from 0.3 to 2.7 per 1000 persons for surgical case definitions, from 0.04 to 1.5 per 1,000 persons for hospital-based case definitions, and from 0.1 to 298.3 per 1,000 persons for clinical case definitions. Factors associated with the development of LDH with radiculopathy included middle-age (30–50 years), smoking, higher BMI, presence of cardiovascular risk factors (in women), and greater cumulative occupational lumbar load by forward bending postures and manual materials handling, with effect sizes ranging from ranging from 1.1 (1.0–1.3) to 3.7 (2.3–6.0). Conclusions Incidence of LDH varies in different populations and according to case definition. Risk factors include individual, behavioural, and work-related variables. Our findings support the need to develop standardised case definitions that validly classify the clinical spectrum of LDH and for future low risk of bias studies examining causal relationships for LDH with radiculopathy in adults.

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IL1R1 Polymorphisms are Associated with Lumbar Disc Herniation Risk in the Northwestern Chinese Han Population

Cited by 7 publications

References 35 publications

Analysis of the Relationship Between Modic Change and Spinopelvic Parameters in the Sagittal Plane

Analysis of the Relationship Between Modic Change and Spinopelvic Parameters in the Sagittal Plane

TNFAIP3 Mediated by Novel Nano Composite Adsorbent on Tumor Necrosis Factor-𝛂 in Rats with Lumbar Disc Herniation by Inhibiting 𝐍𝐅−𝛋𝐁 Pathway

Incidence of and risk factors for lumbar disc herniation with radiculopathy in adults: a systematic review

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