IL7r-alpha fate-mapping labels distinct adult tissue resident macrophages

Beaudin, Anna E.; McCann, Taylor; Leung, Gabriel; Forsberg, Erik

doi:10.1016/j.exphem.2017.06.318

Cited by 1 publication

(1 citation statement)

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“…IL7 signalling is recognised for regulating CD4+ T-cell numbers (increasing numbers upon direct T-cell stimulation, decreasing numbers indirectly through dendritic stimulation) [93], and recently, for regulating tissue resident macrophage development [94]. Accordingly, TRPML3 appears highly expressed in the thymus [3,95], being transcribed in macrophages, CD4+ T-cells, and dendritic cells [95].…”

Section: Trpml3mentioning

confidence: 99%

The protein interaction networks of mucolipins and two-pore channels

Krogsaeter¹,

Biel

Wahl‐Schott

2019

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Background:The endolysosomal, non-selective cation channels, two-pore channels (TPCs) and mucolipins (TRPMLs), regulate intracellular membrane dynamics and autophagy. While partially compensatory for each other, isoform-specific intracellular distribution, cell-type expression patterns, and regulatory mechanisms suggest different channel isoforms confer distinct properties to the cell. Scope of review: Briefly, established TPC/TRPML functions and interaction partners ('interactomes') are discussed. Novel TRPML3 interactors are shown, and a meta-analysis of experimentally obtained channel interactomes conducted. Accordingly, interactomes are compared and contrasted, and subsequently described in detail for TPC1, TPC2, TRPML1, and TRPML3. Major conclusions: TPC interactomes are well-defined, encompassing intracellular membrane organisation proteins. TRPML interactomes are varied, encompassing cardiac contractility-and chaperone-mediated autophagy proteins, alongside regulators of intercellular signalling. General significance: Comprising recently proposed targets to treat cancers, infections, metabolic disease and neurodegeneration, the advancement of TPC/TRPML understanding is of considerable importance. This review proposes novel directions elucidating TPC/TRPML relevance in health and disease.

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