Ileal Involvement Is Age Dependent in Pediatric Crohnʼs Disease

Meinzer, Ulrich; Ideström, Maja; Alberti, Corinne; Peuchmaur, Michel; Belarbi, Nadia; Bellaïche, M.; Jf, Mougenot; Cézard, Jean-Pierre; Finkel, Yigael; Hugot, Jean‐Pierre

doi:10.1097/01.mib.0000165114.10687.bf

Cited by 82 publications

(58 citation statements)

References 31 publications

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“…The number of Peyer's patches increases during childhood and reaches a peak in late adolescence, then it starts to regress (31). This observation may be the link between the lower CRP levels in Crohn colitis.…”

Section: Discussionmentioning

confidence: 90%

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

Müller

Lakatos

Kovács

et al. 2016

J. pediatr. gastroenterol. nutr.

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Section: Discussionmentioning

confidence: 90%

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

Müller

Lakatos

Kovács

et al. 2016

J. pediatr. gastroenterol. nutr.

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“…The phenomenon of age dependence in the phenotypic clinical expression of CD has been reported in some studies. [23][24][25] It is generally believed that CD runs a more aggressive course in young patients. 26,27 Yet the data are still inconsistent.…”

Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal tract phenotype of Crohnʼs disease is associated with early surgery and further hospitalization

Chow

Sung

et al. 2009

Inflammatory Bowel Diseases

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“…The variable age at diagnosis, that is proper to assess time-dependent consequences of CD, in several studies has been related to disease location, gender, and familial history (10,18,21) . In 1996, Polito et al (21) , analyzing a cohort of 552 consecutive patients, found that a lesser age at diagnosis was associated with higher rates of familial history of CD, small bowel onset, stricturing disease, and surgery; younger age at diagnosis was also correlated with genetic factors (12) .…”

Section: Discussionmentioning

confidence: 99%

The Montreal classification for Crohn's disease: clinical application to a Brazilian single-center cohort of 90 consecutive patients

Torres

Rodrigues

Junqueira

et al. 2010

Arq. Gastroenterol.

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CONTEXT: Crohn's disease presents very heterogeneous features from a clinical point of view, and classifying Crohn's disease patients in homogeneous subgroups in the light of genetic, molecular and clinical aspects is challenging. The Montreal Classification for Crohn's disease was proposed in 2005 as an effort to characterize Crohn's disease patients according to recent clinical and research advances in the field of inflammatory bowel disease. Since its proposition, the Montreal Classification needs an ample validation and application among different populations around the world. To date, there are no known studies applying the Montreal Classification to a Brazilian cohort of Crohn's disease patients. OBJECTIVES: To apply the Montreal Classification to a Brazilian cohort of Crohn's disease patients at a referral center for inflammatory bowel disease in Northwestern São Paulo State, Brazil. METHODS: We selected 90 consecutive well-characterized Crohn's disease patients assisted at Inflammatory Bowel Disease Outpatient Clinic between January 1992 and January 2007, with a minimum follow-up of 2 years; data concerning demographic characteristics, clinical onset of disease, age at diagnosis, time of disease, location and behavior of disease, presence of extraintestinal manifestations, familial occurrence, perianal involvement, treatment with biological drugs, and history of surgical treatment were evaluated. RESULTS: Male patients were predominant (54%), with a mean age at diagnosis of 33 ± 14 years old, and a median followup of 5.5 years. Most of the patients were diagnosed between 17 and 40 years old (59%), and had disease located in terminal ileum 46%), with a nonstricturing, nonpenetrating behavior (71%). Time of disease was correlated with necessity of biological treatment, disease behavior, and surgical treatment (P<0.05). CONCLUSIONS: These study findings are consistent with results from other studies conducted among different populations, although a further multicentric study with a larger number of patients would be necessary to validate the Montreal Classification among Brazilian population.

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Ileal Involvement Is Age Dependent in Pediatric Crohnʼs Disease

Cited by 82 publications

References 31 publications

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

Upper gastrointestinal tract phenotype of Crohnʼs disease is associated with early surgery and further hospitalization

The Montreal classification for Crohn's disease: clinical application to a Brazilian single-center cohort of 90 consecutive patients

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