Ileal Ulcers due to Aeromonas hydrophilia Infection

Yamamoto, Takatsugu; Ishii, Taro; Sanaka, Masaki; Saitoh, Masaki; Kawakami, Yasushi

doi:10.1097/00004836-200411000-00018

Cited by 7 publications

(2 citation statements)

References 3 publications

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“…A. hydrophila is an opportunistic pathogen found in healthy frogs, but capable of inducing diseases, such as the natural outbreaks of "red-leg" in Amphibia (45), including the species of R. temporaria (44). Beside causing high mortality in amphibian populations, this bacterium is also responsible for variety of infections in humans (75)(76)(77), especially in immunocompromised individuals, and it has been found to be insensitive to several classical antibiotics (72,74,78). Furthermore, Rollins-Smith and colleagues (45) reported that A. hydrophila is resistant to different peptides of frog skin origin such as magainin I, magainin II, PGLa, CPF, ranalexin, and dermaseptin, when tested in growth inhibition assays.…”

Section: Discussionmentioning

confidence: 99%

A Synergism between Temporins toward Gram-negative Bacteria Overcomes Resistance Imposed by the Lipopolysaccharide Protective Layer

Rosenfeld

Barra

Simmaco

et al. 2006

Journal of Biological Chemistry

119

152

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Temporins are short and homologous antimicrobial peptides (AMPs) isolated from the frog skin of Rana genus. To date, very little is known about the biological significance of the presence of closely related AMPs in single living organisms. Here we addressed this question using temporins A, B, and L isolated from Rana temporaria. We found that temporins A and B are only weakly active toward Gram-negative bacteria. However, a marked synergism occurs when each is mixed with temporin L. To shed light on the underlying mechanisms involved in these activities, we used various experimental strategies to investigate: (i) the effect of the peptides' interaction on both the viability and membrane permeability of intact bacteria and spheroplasts; (ii) their interaction with lipopolysaccharides (LPS) and the effect of LPS on the oligomeric state of temporins, alone or combining one with another; (iii) their structure in solution and when bound to LPS, by using circular dichroism and ATR-FTIR spectroscopies. Our data reveal that temporin L synergizes with A and B by preventing their oligomerization in LPS. This should promote their translocation across the outer membrane into the cytoplasmic membrane. To the best of our knowledge, this is the first study that explains how a combination of native AMPs from the same species can overcome bacterial resistance imposed by the LPS leaflet.

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Section: Discussionmentioning

confidence: 99%

A Synergism between Temporins toward Gram-negative Bacteria Overcomes Resistance Imposed by the Lipopolysaccharide Protective Layer

Rosenfeld

Barra

Simmaco

et al. 2006

Journal of Biological Chemistry

119

152

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“…Although any portion of the colon may be affected, it mostly affects the ascending or transverse sections. Iileal ulceration has also been linked to Aeromonas enteritis (Yamamoto et al, 2004). It may also cause intra-mural intestinal hemorrhage including small bowel obstruction (Block et al, 1994) (Doman et al, 1989).…”

Section: Infections and Symptomsmentioning

confidence: 99%

Bacteriological, Clinical and Virulence Aspects of Aeromonas-associated Diseases in Humans

Bhowmick

Bhattacharjee

2018

Polish Journal of Microbiology

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Aeromonads have been isolated from varied environmental sources such as polluted and drinking water, as well as from tissues and body fluids of cold and warm-blooded animals. A phenotypically and genotypically heterogenous bacteria, aeromonads can be successfully identified by ribotyping and/or by analysing gyrB gene sequence, apart from classical biochemical characterization. Aeromonads are known to cause scepticemia in aquatic organisms, gastroenteritis and extraintestinal diseases such as scepticemia, skin, eye, wound and respiratory tract infections in humans. Several virulence and antibiotic resistance genes have been identified and isolated from this group, which if present in their mobile genetic elements, may be horizontally transferred to other naive environmental bacteria posing threat to the society. The extensive and indiscriminate use of antibiotics has given rise to many resistant varieties of bacteria. Multidrug resistance genes, such as NDM1, have been identified in this group of bacteria which is of serious health concern. Therefore, it is important to understand how antibiotic resistance develops and spreads in order to undertake preventive measures. It is also necessary to search and map putative virulence genes of Aeromonas for fighting the diseases caused by them. This review encompasses current knowledge of bacteriological, environmental, clinical and virulence aspects of the Aeromonas group and related diseases in humans and other animals of human concern.

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Biological characterization and modes of action of temporins and bombinins H, multiple forms of short and mildly cationic anti‐microbial peptides from amphibian skin

Mangoni¹,

Marcellini²,

Simmaco³

2007

Journal of Peptide Science

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Genetically encoded cationic anti-microbial peptides (AMPs) are essential components of the ancient and non-specific innate immune system, which is the principal defence mechanism of all species of life, with the primary role to kill infectious microorganisms. Amphibian skin is one of the richest natural sources of such molecules, which are produced by holocrine-type dermal glands and released upon stimulation. This review highlights the attractive and unique structural/functional properties of temporins and bombinins H, two families of short and mildly cationic peptides, isolated from the skin of frogs belonging to Rana and Bombina genera, respectively. Beside improving our knowledge on the role of AMPs in the regulation of the innate immunity, the biological significance of the existence of multiple forms of a prototypic peptide sequence within the same organism and the implication of short peptides in the endotoxin neutralization, these two classes of AMPs can be also considered as valid candidates for the design of novel anti-infective and anti-sepsis drugs.

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Ileal Ulcers due to Aeromonas hydrophilia Infection

Cited by 7 publications

References 3 publications

A Synergism between Temporins toward Gram-negative Bacteria Overcomes Resistance Imposed by the Lipopolysaccharide Protective Layer

A Synergism between Temporins toward Gram-negative Bacteria Overcomes Resistance Imposed by the Lipopolysaccharide Protective Layer

Bacteriological, Clinical and Virulence Aspects of Aeromonas-associated Diseases in Humans

Biological characterization and modes of action of temporins and bombinins H, multiple forms of short and mildly cationic anti‐microbial peptides from amphibian skin

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